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15 p, 877.1 KB |
Rapid and sustained B-cell depletion with subcutaneous ofatumumab in relapsing multiple sclerosis : APLIOS, a randomized phase-2 study
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Bar-Or, Amit (University of Pennsylvania) ;
Wiendl, Heinz (University of Münster) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Alvarez, Enrique (University of Colorado) ;
Davydovskaya, Maria (Pirogov Russian National Research Medical University) ;
Delgado, Silvia (University of Miami) ;
Evdoshenko, Evgeniy P. (St Petersburg Center for Multiple Sclerosis and Other Autoimmune Diseases) ;
Giedraitiene, Natasa (Vilnius University) ;
Gross-Paju, Katrin (Institute of Health Care Technology) ;
Haldre, Sulev (University of Tartu) ;
Herrman, Craig E. (JWM Neurology) ;
Izquierdo, Guillermo (Hospital Vithas Sevilla) ;
Karelis, Guntis (Riga East University Hospital) ;
Leutmezer, Fritz (Medical University of Vienna) ;
Mares, Miroslav (Pardubice Regional Hospital) ;
Meca-Lallana, Jose Eustasio (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Mickeviciene, Dalia (Lithuanian University of Health Sciences) ;
Nicholas, Jacqueline (Riverside Methodist Hospital) ;
Robertson, Derrick S. (University of South Florida) ;
Sazonov, Denis V. (Department of Clinical Trials FSBIH SDMC of FMBA of Russia) ;
Sharlin, Kenneth (Sharlin Health and Neurology) ;
Sundaram, Bharathy (Texas Institute for Neurological Disorders) ;
Totolyan, Natalia (Pavlov First State Medical University of St. Petersburg) ;
Vachova, Marta (Teplice Hospital) ;
Valis, Martin (Charles University) ;
Bagger, Morten (Novartis) ;
Häring, Dieter A. (Novartis) ;
Ludwig, Inga (Novartis) ;
Willi, Roman (Novartis) ;
Zalesak, Martin (Novartis) ;
Su, Wendy (Novartis) ;
Merschhemke, Martin (Novartis) ;
Fox, Edward J. (Central Texas Neurology Consultants PA) ;
Universitat Autònoma de Barcelona
Background: Ofatumumab, the first fully human anti-CD20 monoclonal antibody, is approved in several countries for relapsing multiple sclerosis (RMS). Objective: To demonstrate the bioequivalence of ofatumumab administered by an autoinjector versus a pre-filled syringe (PFS) and to explore the effect of ofatumumab on B-cell depletion. [...]
2022 -  10.1177/13524585211044479
Multiple sclerosis, Vol. 28 Núm. 6 (2022) , p. 910-924
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18 p, 436.4 KB |
COVID-19 Outcomes and Vaccination in People with Relapsing Multiple Sclerosis Treated with Ofatumumab
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Cross, Anne H. (Department of Neurology. Washington University) ;
Delgado, Silvia (University of Miami Miller School of Medicine) ;
Habek, Mario (University Hospital Center Zagreb. University of Zagreb. School of Medicine) ;
Davydovskaya, Maria (Moscow State Public Healthcare InsCity Clinical Hospital 24) ;
Ward, Brian J. (Infectious Diseases Division. Research Institute of the McGill University Health Centre) ;
Cree, Bruce A. C (UCSF Weill Institute for Neurosciences. Department of Neurology. University of California San Francisco) ;
Totolyan, Natalia (First Saint Petersburg State Medical University) ;
Pingili, Ratnakar (Novartis Pharmaceuticals Corporation) ;
Mancione, Linda (Novartis Pharmaceuticals Corporation) ;
Hu, Xixi (Novartis Pharmaceuticals Corporation) ;
Sullivan, Roseanne (Novartis Pharmaceuticals Corporation) ;
Su, Wendy (Novartis Pharmaceuticals Corporation) ;
Zielman, Ronald (Novartis Pharma B.V.) ;
Gupta, Ayan Das (Novartis Healthcare Private Limited) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Winthrop, Kevin (School of Public Health at Oregon Health and Science University) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Introduction: The SARS-CoV-2 pandemic necessitated better understanding of the impact of disease-modifying therapies on COVID-19 outcomes and vaccination. We report characteristics of COVID-19 cases and vaccination status in ofatumumab-treated relapsing multiple sclerosis (RMS) patients. [...]
2022 - 10.1007/s40120-022-00341-z
Neurology and Therapy, Vol. 11 Núm. 2 (june 2022) , p. 741-758
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4 p, 243.1 KB |
Correction to : COVID-19 Outcomes and Vaccination in People with Relapsing Multiple Sclerosis Treated with Ofatumumab
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Cross, Anne H. (Department of Neurology. Washington University) ;
Delgado, Silvia (University of Miami Miller School of Medicine) ;
Habek, Mario (University Hospital Center Zagreb. University of Zagreb. School of Medicine) ;
Davydovskaya, Maria (Moscow State Public Healthcare InsCity Clinical Hospital 24) ;
Ward, Brian J. (Infectious Diseases Division. Research Institute of the McGill University Health Centre) ;
Cree, Bruce A. C (UCSF Weill Institute for Neurosciences. Department of Neurology. University of California San Francisco) ;
Totolyan, Natalia (First Saint Petersburg State Medical University) ;
Pingili, Ratnakar (Novartis Pharmaceuticals Corporation) ;
Mancione, Linda (Novartis Pharmaceuticals Corporation) ;
Hu, Xixi (Novartis Pharmaceuticals Corporation) ;
Sullivan, Roseanne (Novartis Pharmaceuticals Corporation) ;
Su, Wendy (Novartis Pharmaceuticals Corporation) ;
Zielman, Ronald (Novartis Pharma B.V.) ;
Gupta, Ayan Das (Novartis Healthcare Private Limited) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Winthrop, Kevin (School of Public Health at Oregon Health and Science University) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
2022 - 10.1007/s40120-022-00346-8
Neurology and Therapy, Vol. 11 Núm. 2 (2022) , p. 759-762
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14 p, 478.1 KB |
Clinical response to linaclotide at week 4 predicts sustained response in irritable bowel syndrome with constipation and improvements in digestive and extra-digestive symptoms
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Serrano-Falcón, Blanca (Hospital Clínico San Carlos (Madrid)) ;
Delgado-Aros, Sílvia (Hospital del Mar (Barcelona, Catalunya)) ;
Mearin, Fermín 1956- (Centro Médico Teknon) ;
Ciriza de los Ríos, Constanza (Hospital Universitario 12 de Octubre (Madrid)) ;
Serra Pueyo, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Mínguez, Miguel (Universitat de València) ;
Montoro Huguet, Miguel (Hospital San Jorge) ;
Perelló, Antonia (Hospital de Viladecans) ;
Santander, Cecilio (Universidad Autónoma de Madrid) ;
Pérez-Aisa, Ángeles (Agencia Sanitaria Costa del Sol) ;
Bañón-Rodríguez, Inmaculada (Allergan plc) ;
Rey, Enrique (Hospital Clínico San Carlos, Universidad Complutense)
Linaclotide is approved for the treatment of moderate-to-severe irritable bowel syndrome (IBS) with constipation (IBS-C) in adults. This study aimed to assess factors predictive of a clinical response and improvements in non-IBS symptoms with linaclotide treatment in a Spanish patient population. [...]
2019 - 10.1177/1756284819857358
Therapeutic Advances in Gastroenterology, Vol. 12 (august 2019)
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10 p, 237.0 KB |
Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis
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Amezcua, Lilyana (University of Southern California) ;
Beecham, Ashley (University of Miami. Miller School of Medicine) ;
Delgado, Silvia (University of Miami. Miller School of Medicine) ;
Chinea, Angel (San Juan Multiple Sclerosis Center (Puerto Rico)) ;
Burnett, Margaret (University of Southern California) ;
Manrique, Clara Patricia (University of Miami. Miller School of Medicine) ;
Gomez, Refujia (University of Southern California) ;
Comabella, Manuel (University of San Francisco School of Medicine) ;
Montalban, Xavier (University of San Francisco School of Medicine) ;
Ortega, Melissa (University of Miami. Miller School of Medicine) ;
Tornes, Leticia (University of Miami. Miller School of Medicine) ;
Lund, Brett T. (University of Southern California) ;
Islam, Talat (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Conti, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Oksenberg, Jorge (University of Southern California) ;
McCauley, Jacob L. (University of Miami. Miller School of Medicine) ;
Universitat Autònoma de Barcelona
Hispanics with multiple sclerosis (MS) present younger and more often with optic neuritis (ON) as compared to Whites in the western United States. Regional differences related to Hispanic genetic admixture could be responsible. [...]
2018 - 10.1002/acn3.646
Annals of Clinical and Translational Neurology, Vol. 5, Issue 11 (November 2018) , p. 1362-1371
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16 p, 5.0 MB |
Travestismo y libertad femenina en el siglo XIX mexicano : la biografía de Catalina de Erauso, la Monja Alférez
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Llanos Delgado, Claudia Silvia (Universidad Nacional Autónoma de México)
En este artículo hago un breve análisis sobre una biografía mexicana de Catalina de Erauso, la Monja Alférez, manuscrito anónimo e inédito del siglo XIX. Destaco la relación amorosa de Erauso con Clotilde durante el viaje de ambas de Jalapa a la Ciudad de México para así mostrar que su estilo y contenido permiten situar al texto dentro del subgénero de novela galante, en boga durante el siglo XIX, cuando también la medicina patologizó el travestismo femenino y el lesbianismo. [...]
This article offers a brief analysis of an anonymous, 19th century Mexican biography of Catalina de Erauso, the Lieutenant Nun. I highlight Erauso's love affair with a young woman during a trip from Jalapa to Mexico City. [...]
En aquest article faig un breu anàlisi sobre una biografia mexicana de Catalina de Erauso, la Monja Alférez, manuscrit anònim i inèdit del segle XIX. Destaco la relació amorosa d'Erauso amb Clotilde durant el viatge que van fer les dues de Xalapa a la Ciutat de Mèxic per així mostrar que el seu estil i contingut permeten situar el text dins del subgènere de novel·la galant, en voga durant el segle XIX, quan també la medicina va patologitzar el transvestisme femení i el lesbianisme. [...]
2018 - 10.5565/rev/mitologias.583
Mitologías hoy, Vol. 18 (2018) , p. 111-126 (Dossier)
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12 p, 494.4 KB |
Optimizing the use of linaclotide in patients with constipation-predominant irritable bowel syndrome : an expert consensus report
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Rey, Enrique (Hospital Clínico San Carlos (Madrid)) ;
Mearin, Fermín 1956- (Centro Médico Teknon (Barcelona, Catalunya)) ;
Alcedo, Javier (Hospital Universitario Miguel Servet (Saragossa)) ;
Ciriza de los Ríos, Constanza (Hospital Universitario 12 de Octubre (Madrid)) ;
Delgado-Aros, Sílvia (Neuro-Enteric Translational Science (NETS) Research Group (Barcelona, Catalunya)) ;
Freitas, Teresa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Mascarenhas, Miguel (CUF Porto Hospital (Porto, Portugal)) ;
Mínguez, Miguel (Hospital Clínic Universitari (València)) ;
Santos, Javier (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Serra Pueyo, Jordi (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by chronic or recurrent abdominal pain in association with defecation or a change in bowel habits. A predominant disorder of bowel habits, IBS is classified into three main subtypes: constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D) and IBS alternating between constipation and diarrhea (IBS-M). [...]
2017 - 10.1007/s12325-016-0473-8
Advances in Therapy, Vol. 34 (january 2017) , p. 587-598
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