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Altered Response Hierarchy and Increased T-Cell Breadth upon HIV-1 Conserved Element DNA Vaccination in Macaques
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Kulkarni, Viraj (National Cancer Institute, Frederick, Maryland, United States of America) ;
Valentin, Antonio (National Cancer Institute, Frederick, Maryland, United States of America) ;
Rosati, Margherita (National Cancer Institute, Frederick, Maryland, United States of America) ;
Alicea, Cándido (National Cancer Institute, Frederick, Maryland, United States of America) ;
Singh, Ashish K. (National Cancer Institute, Frederick, Maryland, United States of America) ;
Jalah, Rashmi (National Cancer Institute, Frederick, Maryland, United States of America) ;
Broderick, Kate E. (Inovio Pharmaceuticals, Inc., Blue Bell, Pennsylvania, United States of America) ;
Sardesai, Niranjan Y. (Inovio Pharmaceuticals, Inc., Blue Bell, Pennsylvania, United States of America) ;
Le Gall, Sylvie (Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, United States of America) ;
Mothe, Beatriz (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brander, Christian (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rolland, Morgane (University of Washington, Seattle, Washington, United States of America) ;
Mullins, James I. (University of Washington, Seattle, Washington, United States of America) ;
Pavlakis, George N. (National Cancer Institute, Frederick, Maryland, United States of America) ;
Felber, Barbara K. (National Cancer Institute, Frederick, Maryland, United States of America) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
HIV sequence diversity and potential decoy epitopes are hurdles in the development of an effective AIDS vaccine. A DNA vaccine candidate comprising of highly conserved p24 gag elements (CE) induced robust immunity in all 10 vaccinated macaques, whereas full-length gag DNA vaccination elicited responses to these conserved elements in only 5 of 11 animals, targeting fewer CE per animal. [...]
2014 -  10.1371/journal.pone.0086254
PloS one, Vol. 9 (january 2014)
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