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1.
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19 p, 5.8 MB |
Deep Learning Analyses to Delineate the Molecular Remodeling Process after Myocardial Infarction
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Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rudilla, F (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ferrer-Curriu, Gemma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Segú-Vergés, Cristina (Anaxomics Biotech S.L.) ;
Mellado-Bergillos, Araceli (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gomez-Puchades, Pol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gastelurrutia, Paloma (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Specific proteins and processes have been identified in post-myocardial infarction (MI) pathological remodeling, but a comprehensive understanding of the complete molecular evolution is lacking. We generated microarray data from swine heart biopsies at baseline and 6, 30, and 45 days after infarction to feed machine-learning algorithms. [...]
2021 -  10.3390/cells10123268
Cells, Vol. 10 (november 2021)
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2.
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15 p, 4.3 MB |
Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model
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Monguió-Tortajada, Marta (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Banc de Sang i Teixits) ;
Martínez-Falguera, Daina (Universitat de Barcelona) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Instituto de Salud Carlos III) ;
Courageux, Yvan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Munizaga-Larroudé, Micaela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs i Serres, Francesc Enric (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Rudilla, F. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gálvez-Montón, Carolina (Institut d'Investigació Biomèdica de Bellvitge)
Rationale: Extracellular vesicles (EVs) from mesenchymal stromal cell (MSC) are a potential therapy for cardiac healing after myocardial infarction (MI). Nevertheless, neither their efficient administration nor therapeutic mechanisms are fully elucidated. [...]
2022 - 10.7150/thno.72289
Theranostics, Vol. 12, Issue 10 (June 2022) , p. 4656-4670
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3.
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53 p, 3.5 MB |
Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity
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Benitez Amaro, Aleyda (Institut d'Investigació Biomèdica Sant Pau) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol) ;
Bornachea, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Cedó, Lídia (Institut d'Investigació Biomèdica Sant Pau) ;
Vea, Àngela (Institut d'Investigaciones Biomèdiques de Barcelona) ;
Herrero, Laura (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Roglans, Nuria (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol) ;
Gonzalo Calvo, David de (Institut d'Investigaciones Biomèdiques de Barcelona) ;
Nasarre, Laura (Institut d'Investigaciones Biomèdiques de Barcelona) ;
Camino-López, Sandra (Institut d'Investigaciones Biomèdiques de Barcelona) ;
García, Eduardo (Institut d'Investigaciones Biomèdiques de Barcelona) ;
Mato, Eugenia (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Blanco Vaca, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sebastian, David (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Laguna, Joan Carles (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Serra, Dolors (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Zorzano Olarte, Antonio (Universitat de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Llorente-Cortes, Vicenta (Institut Germans Trias i Pujol)
Background: Low-density lipoprotein receptor-related protein 1 (LRP1) plays a key role in fatty acid metabolism and glucose homeostasis. In the context of dyslipemia, LRP1 is upregulated in the heart. [...]
2020 - 10.1016/j.metabol.2020.154191
Metabolism: Clinical and Experimental, Vol. 160 (may 2020)
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4.
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7 p, 1.6 MB |
Neoinnervation and neovascularization of acellular pericardial-derived scaffolds in myocardial infarcts
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Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernandez-Figueras, M. Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martí, Mercè (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Raya, Ángel (Institució Catalana de Recerca i Estudis Avançats) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Engineered bioimplants for cardiac repair require functional vascularization and innervation for proper integration with the surrounding myocardium. The aim of this work was to study nerve sprouting and neovascularization in an acellular pericardial-derived scaffold used as a myocardial bioimplant. [...]
2015 - 10.1186/s13287-015-0101-6
Stem cell research & therapy, Vol. 6 (may 2015)
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5.
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8 p, 1.6 MB |
Ex vivo assessment and in vivo validation of non-invasive stent monitoring techniques based on microwave spectrometry
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Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ;
Arauz-Garofalo, Gianluca (Universitat de Barcelona. Departament de Física de la Matèria Condensada) ;
Rodriguez-Leor, Oriol (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol) ;
Amorós García de Valdecasas, Susana (Universitat Politècnica de Catalunya. CommSensLab) ;
Gerez-Britos, Flavio David (Universitat de Barcelona. Departament de Física de la Matèria Condensada) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
O'Callaghan, Juan Manuel (Universitat Politècnica de Catalunya. CommSensLab) ;
Macià, Ferran (Universitat de Barcelona. Departament de Física de la Matèria Condensada) ;
Tejada, Javier (Universitat de Barcelona. Departament de Física de la Matèria Condensada)
Some conditions are well known to be directly associated with stent failure, including in-stent re-occlusion and stent fracture. Currently, identification of these high-risk conditions requires invasive and complex procedures. [...]
2018 - 10.1038/s41598-018-33254-9
Scientific reports, Vol. 8 (october 2018)
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6.
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13 p, 4.9 MB |
Head-to-head comparison of two engineered cardiac grafts for myocardial repair : From scaffold characterization to pre-clinical testing
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Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jorba, Ignasi (Universitat de Barcelona) ;
Segú-Vergés, Cristina (Anaxomics Biotech) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Revuelta-López, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernández, Marco A. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Navajas, Daniel (Universitat de Barcelona) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cardiac tissue engineering, which combines cells and supportive scaffolds, is an emerging treatment for restoring cardiac function after myocardial infarction (MI), although, the optimal construct remains a challenge. [...]
2018 - 10.1038/s41598-018-25115-2
Scientific reports, Vol. 8 (april 2018)
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7.
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1 p, 662.5 KB |
Author Correction : Unravelling the effects of mechanical physiological conditioning on cardiac adipose tissue-derived progenitor cells in vitro and in silico
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Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bragos, Ramon (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Roura, Santiago (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
2018 - 10.1038/s41598-018-24808-y
Scientific reports, Vol. 8 (april 2018)
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8.
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9.
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13 p, 3.7 MB |
A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function
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Perea-Gil, Isaac (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ;
Rudilla, F. (Centro de Medicina Regenerativa de Barcelona) ;
Llucià-Valldeperas, Aida (Institut Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol) ;
Iborra Egea, Oriol (Institut Germans Trias i Pujol) ;
Díaz-Güemes, Idoia (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ;
Crisóstomo, Verónica (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ;
Sánchez-Margallo, Francisco M. (Jesús Usón Minimally Invasive Surgery Centre, JUMISC, Cáceres, Spain) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). [...]
2016 - 10.1016/j.jacbts.2016.06.005
JACC: Basic to Translational Science, Vol. 1 (august 2016) , p. 360-372
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10.
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9 p, 1.3 MB |
Mechanisms of action of sacubitril/valsartan on cardiac remodeling : a systems biology approach
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Iborra Egea, Oriol (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez-Montón, Carolina (Institut Germans Trias i Pujol) ;
Rudilla, F. (Institut Germans Trias i Pujol) ;
Perea-Gil, Isaac (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Institut Germans Trias i Pujol) ;
Soler-Botija, Carolina (Institut Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Sacubitril/Valsartan, proved superiority over other conventional heart failure management treatments, but its mechanisms of action remains obscure. In this study, we sought to explore the mechanistic details for Sacubitril/Valsartan in heart failure and post-myocardial infarction remodeling, using an in silico, systems biology approach. [...]
2017 - 10.1038/s41540-017-0013-4
NPJ Systems Biology and Applications, Vol. 3 (april 2017)
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