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21.
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12 p, 774.2 KB |
Kappa free light chains is a valid tool in the diagnostics of MS : A large multicenter study
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Leurs, C. E. (VU University Medical Center. Department of Neurology) ;
Twaalfhoven, Ham (Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry) ;
Lissenberg-Witte, B. I. (Department of Epidemiology and Biostatistics, Amsterdam UMC) ;
van Pesch, V (Department of Neurology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain) ;
Dujmovic, Irena (Clinic of Neurology, Clinical Centre of Serbia, School of Medicine, University of Belgrade) ;
Drulovic, Jelena (Clinic of Neurology, Clinical Centre of Serbia, School of Medicine, University of Belgrade) ;
Castellazzi, M. (Department of Biomedical and Specialty Surgical Sciences, University of Ferrara) ;
Bellini, T. (Department of Biomedical and Specialty Surgical Sciences, University of Ferrara) ;
Pugliatti, M. (Department of Biomedical and Specialty Surgical Sciences, University of Ferrara) ;
Kuhle, Jens (Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedicine, University Hospital Basel) ;
Villar, L. M. (Hospital Ramón y Cajal. Departamento de Inmunologia) ;
Alvarez-Cermeño, José C (Hospital Ramón y Cajal. Departamento de Neurologia) ;
Alvarez-Lafuente, Roberto (Instituto de Investigación Sanitaria San Carlos) ;
Hegen, Harald (Department of Neurology, Medical University of Innsbruck) ;
Deisenhammer, Florian (Department of Neurology, Medical University of Innsbruck) ;
Walchhofer, L. M. (Department of Neurology, Medical University of Innsbruck) ;
Thouvenot, Eric (Hôpital Caremeau, Nîmes. Departement of Neurology) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vécsei, L. (Department of Neurology, University of Szeged) ;
Rajda, C. (Department of Neurology, University of Szeged) ;
Galimberti, Daniela (Multiple Sclerosis Centre, University of Milan) ;
Scarpini, E. (Multiple Sclerosis Centre, University of Milan) ;
Altintas, Ayse (Koc University, School of Medicine, Neurology Department) ;
Rejdak, K. (Department of Neurology, Medical University of Lublin) ;
Frederiksen, J. L. (Department of Neurology, Rigshospitalet Glostrup and University of Copenhagen) ;
Pihl-Jensen, G. (Department of Neurology, Rigshospitalet Glostrup and University of Copenhagen) ;
Jensen, Peh (Danish Multiple Sclerosis Centre, Department of Neurology, Rigshospitalet, University of Copenhagen) ;
Khalil, Michael (Department of Neurology, Medical University of Graz) ;
Voortman, Margarete (Department of Neurology, Medical University of Graz) ;
Fazekas, F. (Department of Neurology, Medical University of Graz) ;
Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
La Puma, D. (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Vercammen, M. (Department of Laboratory Medicine, AZ Sint-Jan Brugge-Oostende) ;
Vanopdenbosch, L. (Department of Neurology, AZ Sint-Jan Brugge-Oostende) ;
Uitdehaag, BMJ (Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC) ;
Killestein, Joep (Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC) ;
Bridel, C. (Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry) ;
Teunissen, Charlotte E. (Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry) ;
Universitat Autònoma de Barcelona. Departament de Medicina
To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. [...]
2019 -  10.1177/1352458519845844
Multiple sclerosis, Vol. 26 (may 2019) , p. 912-923
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22.
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10 p, 1.6 MB |
Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course
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Gil Varea, Elia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Vilariño-Güell, Carles (University of British Columbia. Department of Medical Genetics) ;
Costa, Carme (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Rodríguez-Antigüedad, Alfredo (Hospital de Basurto (Bilbao, Biscaia)) ;
Oksenberg, Jorge (University of California. Department of Neurology) ;
Espino-Paisan, Laura (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Dessa Sadovnick, A. (University of British Columbia. Department of Medical Genetics) ;
Saiz, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Villar, Luisa M. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
García-Merino, Juan Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Ramió-Torrentà, Lluís (Hospital Universitari de Girona Doctor Josep Trueta) ;
Triviño, Juan Carlos (Genomic Systems, Valencia, Spain) ;
Quintana, Ester (Hospital Universitari de Girona Doctor Josep Trueta) ;
Robles, René (Hospital Universitari de Girona Doctor Josep Trueta) ;
Sánchez-López, Antonio (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Arroyo, Rafael (Hospital Universitario Quirón Salud. Servicio de Neurología) ;
Alvarez-Cermeño, José C (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fissolo, Nicolás (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
It remains unclear whether disease course in multiple sclerosis (MS) is influenced by genetic polymorphisms. Here, we aimed to identify genetic variants associated with benign and aggressive disease courses in MS patients. [...]
2018 - 10.1186/s12974-018-1307-1
Journal of neuroinflammation, Vol. 15 (september 2018)
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23.
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12 p, 3.3 MB |
Adaptive Features of Natural Killer Cells in Multiple Sclerosis
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Moreira Villanueva, Antía (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Alari-Pahissa, Elvira (Universitat Pompeu Fabra) ;
Munteis, Elvira (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Vera, Andrea (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Zabalza, Ana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Llop, Mireia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Villarrubia, Noelia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Costa-Garcia, Marcel (Universitat Pompeu Fabra) ;
Alvarez-Lafuente, Roberto (Hospital Clínico San Carlos (Madrid)) ;
Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ;
López-Botet, Miguel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martínez-Rodríguez, José E. (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Human cytomegalovirus (HCMV) has been recently related with a lower susceptibility to multiple sclerosis (MS). HCMV promotes an adaptive development of NK cells bearing the CD94/NKG2C receptor with a characteristic phenotypic and functional profile. [...]
2019 - 10.3389/fimmu.2019.02403
Frontiers in immunology, Vol. 10 (15 2019) , p. 2403
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24.
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18 p, 3.0 MB |
Manipulation of gut microbiota influences immune responses, axon preservation, and motor disability in a model of progressive multiple sclerosis
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Mestre, Leyre (Red Española de Esclerosis Múltiple (REEM)) ;
Carrillo-Salinas, Francisco J (Instituto Cajal (Consejo Superior de Investigaciones Científicas)) ;
Mecha, Miriam (Red Española de Esclerosis Múltiple (REEM)) ;
Feliú, Ana (Red Española de Esclerosis Múltiple (REEM)) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Cermeño, José C (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Villar, L. M. (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Guaza, C. (Red Española de Esclerosis Múltiple (REEM))
Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Using a well-established model of progressive MS triggered by intracranial infection with Theiler's murine encephalomyelitis virus (TMEV), we sought to determine whether dysbiosis induced by oral antibiotics (ABX) administered on pre-symptomatic and symptomatic phases of the disease influences its course. [...]
2019 - 10.3389/fimmu.2019.01374
Frontiers in immunology, Vol. 10 Núm. JUN (2019) , p. 1374
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25.
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26.
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9 p, 405.7 KB |
Neurofilament light chain level is a weak risk factor for the development of MS
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Arrambide, Georgina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Espejo, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Eixarch, Herena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villar, Luisa M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alvarez-Cermeño, José C. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Picón, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Kuhle, Jens (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Disanto, Giulio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Kappos, Ludwig (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pareto, Deborah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Simon, Eva (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Río, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Nos, Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tur, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castilló, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Galan, Ingrid (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Arévalo, María Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Auger, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
To determine the prognostic value of selected biomarkers in clinically isolated syndromes (CIS) for conversion to multiple sclerosis (MS) and disability accrual. Data were acquired from 2 CIS cohorts. [...]
2016 - 10.1212/WNL.0000000000003085
Neurology, Vol. 87 (september 2016) , p. 1076-1084
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27.
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7 p, 1018.1 KB |
Analysis of Plasminogen Genetic Variants in Multiple Sclerosis Patients
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Sadovnick, A. Dessa (University of British Columbia) ;
Traboulsee, Anthony L. (University of British Columbia) ;
Bernales, Cecily Q. (University of British Columbia) ;
Ross, Jay P. (University of British Columbia) ;
Forwell, Amanda L. (University of British Columbia) ;
Yee, Irene M. (University of British Columbia) ;
Guillot-Noel, Lena (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Fontaine, Bertrand (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Cournu-Rebeix, Isabelle (Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, France) ;
Alcina, Antonio (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Fedetz, Maria (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Izquierdo, Guillermo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Matesanz, Fuencisla (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Hilven, Kelly (University of Leuven) ;
Dubois, Bénédicte (University Hospitals Leuven (Bèlgica)) ;
Goris, An (University of Leuven) ;
Astobiza, Ianire (Achucarro Basque Center for Neuroscience) ;
Alloza, Iraide (IKERBASQUE, Basque Foundation for Science) ;
Antigüedad, Alfredo (Hospital de Basurto (Bilbao, Biscaia)) ;
Vandenbroeck, Koen (IKERBASQUE, Basque Foundation for Science) ;
Akkad, Denis A. (Ruhr University) ;
Aktas, Orhan (Heinrich Heine University) ;
Blaschke, Paul (University of Rostock) ;
Buttmann, Mathias (University of Würzburg) ;
Chan, Andrew (Bern University Hospital) ;
Epplen, Joerg T. (Ruhr University) ;
Gerdes, Lisa-Ann (Institute for Clinical Neuroimmunology, Ludwig Maximilian University) ;
Kroner, Antje (Medical College of Wisconsin) ;
Kubisch, Christian (University Medical Center Hamburg-Eppendorf) ;
Kümpfel, Tania (Ludwig Maximilian University) ;
Lohse, Peter (Institute of Laboratory Medicine and Human Genetics) ;
Rieckmann, Peter (Sozialstiftung Bamberg Hospital) ;
Zettl, Uwe K. (University of Rostock) ;
Zipp, Frauke (University Medical Center of the Johannes Gutenberg-University Mainz) ;
Bertram, Lars (Imperial College London) ;
Lill, Christina M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández, Oscar (Instituto de Investigación Biomédica de Málaga) ;
Urbaneja, Patricia (Instituto de Investigación Biomédica de Málaga) ;
Leyva, Laura (Instituto de Investigación Biomédica de Málaga) ;
Alvarez-Cermeño, José C (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Arroyo, Rafael (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Garagorri, Aroa M. (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
García-Martínez, Angel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Villar, Luisa M. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Urcelay, Elena (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Berger, Thomas (Medical University of Innsbruck) ;
Fazekas, Franz (Medical University of Graz) ;
Reindl, Markus (Medical University of Innsbruck) ;
Schmied, Mascha C. (Medical University of Vienna) ;
Zimprich, Alexander (Medical University of Vienna) ;
Vilariño-Güell, Carles (University of British Columbia) ;
Universitat Autònoma de Barcelona
Multiple sclerosis (MS) is a prevalent neurological disease of complex etiology. Here, we describe the characterization of a multi-incident MS family that nominated a rare missense variant (p. G420D) in plasminogen (PLG) as a putative genetic risk factor for MS. [...]
2016 - 10.1534/g3.116.030841
G3, Vol. 6 (may 2016) , p. 2073-2079
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28.
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5 p, 320.8 KB |
Natalizumab-related anaphylactoid reactions in MS patients are associated with HLA class II alleles
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de la Hera, Belén (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Urcelay, Elena (Hopital Purpan, Toulouse) ;
Brassat, David (Ruhr University, Bochum) ;
Chan, Andrew ;
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salmen, Anke (St. Josef-Hospital) ;
Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ;
Alvarez-Cermeño, José C (Hospital Universitario Ramón y Cajal (Madrid)) ;
Izquierdo, Guillermo (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Fernández, Oscar (Hospital Regional Universitario de Málaga) ;
Oliver, Begoña (Instituto de Investigación Biomédica de Málaga) ;
Saiz, Albert (Hospital Clínic i Provincial de Barcelona) ;
Ara, Jose Ramón (Universidad de Zaragoza) ;
Vigo, Ana G. ;
Arroyo, Rafael ;
Meca-Lallana, Virginia (Hospital Universitario de la Princesa (Madrid)) ;
Malhotra, Sunny (Hospital Universitari Vall d'Hebron) ;
Fissolo, Nicolás (Hospital Universitari Vall d'Hebron) ;
Horga, Alejandro ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
We aimed to investigate potential associations between human leukocyte antigen (HLA) class I and class II alleles and the development of anaphylactic/anaphylactoid reactions in patients with multiple sclerosis (MS) treated with natalizumab. [...]
2014 - 10.1212/NXI.0000000000000047
Neurology® neuroimmunology & neuroinflammation, Vol. 1 (december 2014)
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29.
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9 p, 542.1 KB |
Validation of semaphorin 7A and ala-β-his-dipeptidase as biomarkers associated with the conversion from clinically isolated syndrome to multiple sclerosis
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Cantó Puig, Ester (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Tintoré, Mar ;
Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ;
Borràs, Eva (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Alvarez-Cermeño, José C (Hospital Universitario Ramón y Cajal (Madrid)) ;
Chiva, Cristina (Universitat Pompeu Fabra) ;
Sabidó, Eduard (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
In a previous proteomics study using pooled cerebrospinal fluid (CSF) samples, we proposed apolipoprotein AI, apolipoprotein AIV, vitronectin, plasminogen, semaphorin 7A, and ala-β-his-dipeptidase as candidate biomarkers associated with the conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndromes (CIS). [...]
2014 - 10.1186/s12974-014-0181-8
Journal of neuroinflammation, Vol. 11 (november 2014)
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30.
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