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1.
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14 p, 7.4 MB |
Chromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
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Llinàs-Arias, Pere (Institut d'Investigació Sanitària Illes Balears) ;
Ensenyat Méndez, Miquel (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Íñiguez-Muñoz, Sandra (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Orozco, Javier I.J. (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA) ;
Valdez, Betsy (Saint John's Cancer Institute, Providence Saint John's Health Center, Santa Monica, CA, USA.) ;
Salomon, Matthew P. (University of Southern California, Los Angeles, USA) ;
Matsuba, Chikako (University of Southern California, Los Angeles, USA) ;
Solivellas-Pieras, Maria (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Bedoya-López, Andrés F. (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Sesé, Borja (Cancer Epigenetics Laboratory. Health Research Institute of the Balearic Islands (IdISBa)) ;
Mezger, Anja (Science for Life Laboratory, Solna, Sweden) ;
Ormestad, Mattias (Science for Life Laboratory, Solna, Sweden) ;
Unzueta, Fernando (Universitat de Barcelona) ;
Strand, Siri H. (Stanford University School of Medicine, Stanford, USA) ;
Boiko, Alexander D. (Samuel Oschin Comprehensive Cancer Institute, Los Angeles, USA) ;
Hwang, E.Shelley (Duke University School of Medicine, Durham, USA) ;
Cortés, Javier (Universidad Europea de Madrid) ;
DiNome, Maggie L. (Duke University School of Medicine, Durham, USA) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lupien, Mathieu (University of Toronto) ;
Marzese, Diego (Cancer Epigenetics Laboratory, Health Research Institute of the Balearic Islands (IdISBa))
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matrix metalloprotease (MMP) dysregulation impacting tumor invasion, which is the first step of the metastatic process. [...]
2023 -  10.1186/s12943-023-01906-8
Molecular cancer, Vol. 22 Núm. 1 (november 2023)
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2.
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16 p, 2.1 MB |
A protein-coding gene expression atlas from the brain of pregnant and non-pregnant goats
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Luigi Sierra, Maria Gracia (Centre de Recerca en Agrigenòmica) ;
Guan, Dailu (Centre de Recerca en Agrigenòmica) ;
López Béjar, Manel (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Casas Díaz, Encarna (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Olvera-Maneu, Sergi (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Gardela Santacruz, Jaume (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Palomo Peiró, María Jesús (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Osuagwuh, Uchebuchi Ike (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Ohaneje, Uchechi Linda (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Mármol-Sánchez, Emilio (Centre de Recerca en Agrigenòmica) ;
Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Background: The brain is an extraordinarily complex organ with multiple anatomical structures involved in highly specialized functions related with behavior and physiological homeostasis. Our goal was to build an atlas of protein-coding gene expression in the goat brain by sequencing the transcriptomes of 12 brain regions in seven female Murciano-Granadina goats, from which three of them were 1-month pregnant. [...]
2023 - 10.3389/fgene.2023.1114749
Frontiers in genetics, Vol. 14 (july 2023)
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3.
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11 p, 5.0 MB |
Fibroblast activation and abnormal extracellular matrix remodelling as common hallmarks in three cancer-prone genodermatoses
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Chacón-Solano, Esteban (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
León Canseco, Carlos (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Díaz, F. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
García-García, Francisco (Bioinformatics and Biostatistics Unit. Centro de Investigación Príncipe Felipe (CIPF)) ;
García, M. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Escámez Toledano, María José (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Guerrero-Aspizua, Sara (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Conti, C.J. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Mencía, None (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Martínez-Santamaría, L. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Llames, S. (Tissue Engineering Unit. Centro Comunitario Sangre y Tejidos (CCST)) ;
Pévida, M. (Tissue Engineering Unit. Centro Comunitario Sangre y Tejidos (CCST)) ;
Carbonell-Caballero, J. (Department of Computational Genomics. Centro de Investigación Príncipe Felipe (CIPF)) ;
Puig-Butille, Joan Anton (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Maseda, R. (Department of Pediatric Dermatology. La Paz Hospital) ;
Puig, Susana (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
de Lucas, R. (Department of Pediatric Dermatology. La Paz Hospital) ;
Baselga Torres, Eulàlia (Institut d'Investigació Biomèdica Sant Pau) ;
Larcher, F. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Dopazo, J. (Bioinformatics in Rare Diseases (BiER-U715). CIBERER. FPS. Hospital Virgen del Rocío) ;
del Río, M. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714))
Background: Recessive dystrophic epidermolysis bullosa (RDEB), Kindler syndrome (KS) and xeroderma pigmentosum complementation group C (XPC) are three cancer-prone genodermatoses whose causal genetic mutations cannot fully explain, on their own, the array of associated phenotypic manifestations. [...]
2019 - 10.1111/bjd.17698
British journal of dermatology, Vol. 181 Núm. 3 (january 2019) , p. 512-522
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4.
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17 p, 12.5 MB |
Impact of the climatic changes in the Pliocene-Pleistocene transition on Irano-Turanian species. The radiation of genus Jurinea (Compositae)
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Herrando-Moraira, Sonia (Institut Botànic de Barcelona) ;
Roquet, Cristina (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Calleja, Juan Antonio (Research Centre on Biodiversity and Global Change. Departament of Biology) ;
Chen, You-Sheng (Chinese Academy of Sciences) ;
Fujikawa, Kazumi (Kochi Prefectural Makino Botanical Garden) ;
Galbany-Casals, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Garcia-Jacas, Núria (Institut Botànic de Barcelona) ;
Liu, Jian-Quan (Key Sichuan University) ;
López-Alvarado, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
López-Pujol, Jordi (Universidad Espíritu Santo . Escuela de Ciencias Ambientales) ;
Mandel, Jennifer R. (University of Memphis. Department of Biological Sciences) ;
Mehregan, Iraj (Islamic Azad University. Department of Biology) ;
Sáez, Llorenç (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Sennikov, Alexander N. (Finnish Museum of Natural History) ;
Susanna, Alfonso (Institut Botànic de Barcelona) ;
Vilatersana, Roser (Institut Botànic de Barcelona) ;
Xu, Lian-Sheng (Chinese Academy of Sciences)
The Irano-Turanian region is one of the world's richest floristic regions and the centre of diversity for numerous xerophytic plant lineages. However, we still have limited knowledge on the timing of evolution and biogeographic history of its flora, and potential drivers of diversification remain underexplored. [...]
2023 - 10.1016/j.ympev.2023.107928
Molecular Phylogenetics and Evolution, Vol. 189 (December 2023) , art. 107928
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5.
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22 p, 4.6 MB |
African Mountain Thistles : Three New Genera in the Carduus-Cirsium Group
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Moreyra, Lucía D. (Institut Botànic de Barcelona) ;
Garcia-Jacas, Núria (Institut Botànic de Barcelona) ;
Roquet, Cristina (Universitat Autònoma de Barcelona) ;
Ackerfield, Jennifer R. (Colorado State University. Department of Biology) ;
Arabacı, Turan (Inönü University. Department of Pharmaceutical Botany) ;
Blanco-Gavaldà, Carme (Universitat Autònoma de Barcelona) ;
Brochmann, Christian (University of Oslo. Natural History Museum) ;
Calleja, Juan Antonio (Universidad Autónoma de Madrid. Centro de Investigación en Biodiversidad y Cambio Global) ;
Dirmenci, Tuncay (Balıkesir University. Department of Biology) ;
Fujikawa, Kazumi (Kochi Prefectural Makino Botanical Garden) ;
Galbany-Casals, Mercè (Universitat Autònoma de Barcelona) ;
Gao, Tiangang (Chinese Academy of Sciences. State Key Laboratory of Systematic and Evolutionary Botany) ;
Gizaw, Abel (Addis Ababa University. Department of Plant Biology and Biodiversity Management) ;
López-Alvarado, Javier (Universitat Autònoma de Barcelona) ;
Mehregan, Iraj (Islamic Azad University. Department of Biology, Science and Research Branch) ;
Vilatersana, Roser (Institut Botànic de Barcelona) ;
Yıldız, Bayram (Ismail Cem Street) ;
Leliaert, Frederik (Meise Botanic Garden) ;
Seregin, Alexey P. (M. V. Lomonosov Moscow State University) ;
Susanna, Alfonso (Institut Botànic de Barcelona)
The floras on the highest mountains in tropical eastern Africa are among the most unique floras in the world. Despite the exceptionally high concentration of endemic species, these floras remain understudied from an evolutionary point of view. [...]
2023 - 10.3390/plants12173083
Plants, Vol. 12, Issue 17 (August 2023) , art. 3083
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7.
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12 p, 1.4 MB |
Genetic architecture of innate and adaptive immune cells in pigs
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Ballester Devis, Maria (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Jové-Juncà, Teodor (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Pascual, Afra (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
López-Serrano, Sergi (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Crespo-Piazuelo, Daniel (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Hernández-Banqué, Carles (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
González-Rodríguez, Olga (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Ramayo-Caldas, Yuliaxis (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Quintanilla, Raquel (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal)
Pig industry is facing new challenges that make necessary to reorient breeding programs to produce more robust and resilient pig populations. The aim of the present work was to study the genetic determinism of lymphocyte subpopulations in the peripheral blood of pigs and identify genomic regions and biomarkers associated to them. [...]
2023 - 10.3389/fimmu.2023.1058346
Frontiers in immunology, Vol. 14 (february 2023)
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8.
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11 p, 1.7 MB |
In silico validation of RNA-Seq results can identify gene fusions with oncogenic potential in glioblastoma
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Hernández, Ainhoa (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Muñoz-Mármol, Ana Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Esteve-Codina, Anna (Universitat Pompeu Fabra) ;
Alameda, Francesc (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pineda, Estela (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Arpí Lluciá, Oriol (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martinez-García, Maria (Hospital del Mar (Barcelona, Catalunya)) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gut, Marta (Universitat Pompeu Fabra) ;
Del Barco Berrón, Sonia (Hospital Universitari de Girona Doctor Josep Trueta) ;
Gallego Rubio, Oscar (Institut d'Investigació Biomèdica Sant Pau) ;
Dabad, Marc (Universitat Pompeu Fabra) ;
Mesia, Carlos (Institut d'Investigació Biomèdica de Bellvitge) ;
Bellosillo Paricio, Beatriz (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Domènech Viñolas, Marta (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Vidal, Noemí (Hospital Universitari de Bellvitge) ;
Aldecoa, Iban (Universitat de Barcelona) ;
de la Iglesia, Nuria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Balañá, Carmen (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Universitat Autònoma de Barcelona
RNA-Sequencing (RNA-Seq) can identify gene fusions in tumors, but not all these fusions have functional consequences. Using multiple data bases, we have performed an in silico analysis of fusions detected by RNA-Seq in tumor samples from 139 newly diagnosed glioblastoma patients to identify in-frame fusions with predictable oncogenic potential. [...]
2022 - 10.1038/s41598-022-18608-8
Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 14439
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9.
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1 p, 179.2 KB |
Corrigendum : Dual Host and Pathogen RNA-Seq Analysis Unravels Chicken Genes Potentially Involved in Resistance to Highly Pathogenic Avian Influenza Virus Infection
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Perlas, Albert (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Argilaguet, Jordi 1977- (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Bertran, Kateri (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Sánchez-González, Raúl (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Nofrarías Espadamala, Miquel (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Valle, Rosa (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Ramis Salva, Antonio José (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Cortey, Martí (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Majó i Masferrer, Natàlia (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
2022 - 10.3389/fimmu.2022.939849
Frontiers in immunology, Vol. 13 (may 2022)
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12 p, 714.2 KB |
Characterization of the Impact of Density Gradient Centrifugation on the Profile of the Pig Sperm Transcriptome by RNA-Seq
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Lian, Yu (Centre de Recerca en Agrigenòmica) ;
Gòdia, Marta (Centre de Recerca en Agrigenòmica) ;
Castelló Farré, Anna (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Rodríguez Gil, Joan Enric (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Balasch, Sam (Grup Gepork S.A. (Barcelona)) ;
Sánchez Bonastre, Armando (Centre de Recerca en Agrigenòmica) ;
Clop, Alex (Centre de Recerca en Agrigenòmica)
RNA-Seq data from human semen suggests that the study of the sperm transcriptome requires the previous elimination from the ejaculates of somatic cells carrying a larger load of RNA. Semen purification is also carried to study the sperm transcriptome in other species including swine and it is often done by density gradient centrifugation to obtain viable spermatozoa from fresh ejaculates or artificial insemination doses, thereby limiting the throughput and remoteness of the samples that can be processed in one study. [...]
2021 - 10.3389/fvets.2021.668158
Frontiers in Veterinary Science, Vol. 8 (July 2021) , art. 668158
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