Web of Science: 35 citations, Scopus: 34 citations, Google Scholar: citations,
The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature
Díaz Beyá, Marina (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Brunet Mauri, Maria Salut (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Nomdedéu Guinot, Josep Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Pratcorona, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Cordeiro, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Gallardo, David (Institut Català d'Oncologia)
Escoda, Lourdes (Hospital Joan XXIII (Tarragona))
Tormo, Mar (Hospital Clínico y Universitario de Valencia)
Heras, Inmaculada (Hospital General Universitario Morales Meseguer (Múrcia))
Ribera Santasusana, J. M. (José María) (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Duarte, Rafael (Institut Català d'Oncologia)
Llano Queipo, María Paz de (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Bargay, Joan (Hospital Son Llàtzer (Palma de Mallorca, Mallorca))
Sampol, Antonia (Hospital Son Espases (Palma de Mallorca, Mallorca))
Nomdedeu, Meritxell (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Risueño, Ruth M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Hoyos, Montserrat (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Sierra Gil, Jorge (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Monzo, Mariano (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Navarro, Alfons (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Esteve, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Cooperative AML group CETLAM
Universitat Autònoma de Barcelona

Date: 2015
Abstract: Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myeloid leukemia (AML) is mostly unknown. We have examined the expression of the lncRNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) in 241 AML patients. We have correlated HOTAIRM1 expression with a miRNA expression profile. We have also analyzed the prognostic value of HOTAIRM1 expression in 215 intermediate-risk AML (IR-AML) patients. The lowest expression level was observed in acute promyelocytic leukemia (P < 0. 001) and the highest in t(6;9) AML (P = 0. 005). In 215 IR-AML patients, high HOTAIRM1 expression was independently associated with shorter overall survival (OR:2. 04;P = 0. 001), shorter leukemia-free survival (OR:2. 56; P < 0. 001) and a higher cumulative incidence of relapse (OR:1. 67; P = 0. 046). Moreover, HOTAIRM1 maintained its independent prognostic value within the favorable molecular subgroup (OR: 3. 43; P = 0. 009). Interestingly, HOTAIRM1 was overexpressed in NPM1-mutated AML (P < 0. 001) and within this group retained its prognostic value (OR: 2. 21; P = 0. 01). Moreover, HOTAIRM1 expression was associated with a specific 33-microRNA signature that included miR-196b (P < 0. 001). miR-196b is located in the HOX genomic region and has previously been reported to have an independent prognostic value in AML. miR-196b and HOTAIRM1 in combination as a prognostic factor can classify patients as high-, intermediate-, or low-risk (5-year OS: 24% vs 42% vs 70%; P = 0. 004). Determination of HOTAIRM1 level at diagnosis provided relevant prognostic information in IR-AML and allowed refinement of risk stratification based on common molecular markers. The prognostic information provided by HOTAIRM1 was strengthened when combined with miR-196b expression. Furthermore, HOTAIRM1 correlated with a 33-miRNA signature.
Note: Altres ajuts: SDCSD from School of Medicine, University of Barcelona
Note: Número d'acord de subvenció ISCIII/CM13/00205
Note: Número d'acord de subvenció ISCIII/PI13/00999
Note: Número d'acord de subvenció ISCIII/RETICS/RD12/0036/0010
Rights: Tots els drets reservats
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Leucèmia ; Genètica ; AML ; HOTAIRM ; HOX ; Lincrna ; Lncrna
Published in: Oncotarget, Vol. 6 Núm. 31 (October 2015) , ISSN 1949-2553

DOI: 10.18632/oncotarget.5148
PMID: 26436590


15 p, 1.7 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles

 Record created 2016-07-26, last modified 2019-02-08



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