Web of Science: 4 cites, Scopus: 4 cites, Google Scholar: cites
Striking structural dynamism and nucleotide sequence variation of the transposon Galileo in the genome of Drosophila mojavensis
Marzo, Mar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Bello, Xabier (Universidade de Santiago de Compostela. Departamento de Anatomía Patolóxica e Ciencias Forenses)
Puig Font, Marta (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Maside, Xulio (Universidade de Santiago de Compostela. Departamento de Anatomía Patolóxica e Ciencias Forenses)
Ruiz, Alfredo, (Ruiz Panadero) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"

Data: 2013
Resum: Galileo is a transposable element responsible for the generation of three chromosomal inversions in natural populations of Drosophila buzzatii. Although the most characteristic feature of Galileo is the long internally-repetitive terminal inverted repeats (TIRs), which resemble the Drosophila Foldback element, its transposase-coding sequence has led to its classification as a member of the P-element superfamily (Class II, subclass 1, TIR order). Furthermore, Galileo has a wide distribution in the genus Drosophila, since it has been found in 6 of the 12 Drosophila sequenced genomes. Among these species, D. mojavensis, the one closest to D. buzzatii, presented the highest diversity in sequence and structure of Galileo elements. In the present work, we carried out a thorough search and annotation of all the Galileo copies present in the D. mojavensis sequenced genome. In our set of 170 Galileo copies we have detected 5 Galileo subfamilies (C, D, E, F, and X) with different structures ranging from nearly complete, to only 2 TIR or solo TIR copies. Finally, we have explored the structural and length variation of the Galileo copies that point out the relatively frequent rearrangements within and between Galileo elements. Different mechanisms responsible for these rearrangements are discussed. Although Galileo is a transposable element with an ancient history in the D. mojavensis genome, our data indicate a recent transpositional activity. Furthermore, the dynamism in sequence and structure, mainly affecting the TIRs, suggests an active exchange of sequences among the copies. This exchange could lead to new subfamilies of the transposon, which could be crucial for the long-term survival of the element in the genome.
Ajuts: Ministerio de Ciencia e Innovación BFU2008-04988
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Transposable element ; Drosophila mojavensis ; Evolution ; Terminal inverted repeat ; Phylogeny ; Genomics
Publicat a: Mobile DNA, Vol. 4 (2013) , art. 6, ISSN 1759-8753

DOI: 10.1186/1759-8753-4-6
PMID: 23374229


13 p, 981.6 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2018-01-27, darrera modificació el 2022-04-04



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