Web of Science: 7 citations, Scopus: 9 citations, Google Scholar: citations,
Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells
Oliveira, Elisabete (Universidade Nova de Lisboa. Faculdade de Ciências e Tecnologia)
Santos, Hugo M. (Universidade Nova de Lisboa. Faculdade de Ciências e Tecnologia)
Garcia Pardo, Javier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Diniz, Mário (Universidade Nova de Lisboa. Faculdade de Ciências e Tecnologia)
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Rodríguez-González, Benito (Centro de Apoyo Científico y Tecnológico a la Investigación)
Capelo, José L. (Universidade Nova de Lisboa. Faculdade de Ciências e Tecnologia)
Lodeiro, Carlos (Universidade Nova de Lisboa. Faculdade de Ciências e Tecnologia)

Date: 2013
Abstract: Silver nanoparticles, AgNPs, are widely used in our daily life, mostly due to their antibacterial, antiviral, and antifungal properties. However, their potential toxicity remains unclear. In order to unravel this issue, emissive AgNPs were first synthetized using an inexpensive photochemical method, and then their permeation was assessed in vivo in goldfish and in vitro in human hepatoma cells (HepG2). In addition, the oxidative stress caused by AgNPs was assessed in enzymes such as glutathione-S-transferase (GST), catalase (CAT), and in lipid peroxidation (LPO). This study demonstrates that the smallest sized AgNPs@ 3 promote the largest changes in gold fish livers, whereas AgNPs@ 1 were found to be toxic in HEPG2 cells depending on both the size and functionalized/stabilizer ligand.
Note: Número d'acord de subvenció MICINN/BIO2010-22321-C02.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Silver nanoparticles ; Fluorescence ; Cytotoxicity ; Goldfish ; Human hepatoma cells
Published in: Frontiers in chemistry, Vol. 1, art. 29 (Dec. 2013) , ISSN 2296-2646

PMID: 24790957
DOI: 10.3389/fchem.2013.00029


11 p, 2.5 MB

The record appears in these collections:
Articles > Research articles
Articles > Published articles

 Record created 2018-01-27, last modified 2019-01-25



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