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Pàgina inicial > Articles > Articles publicats > Expression of IL-1α correlates with distant metastasis in patients with head and neck squamous cell carcinoma |
Data: | 2015 |
Resum: | The presence of IL-1 in human cancers is associated with aggressive tumor biology but its prognostic value is unknown. We studied whether IL-1α expression is a prognostic marker of distant metastasis in patients with head and neck squamous cell carcinoma (HNSCC). IL-1α mRNA and protein levels were determined in tumor samples and cancer cell lines using RT-PCR and ELISA. The effects of constitutive IL-1α expression by tumor lines were characterized. IL-1α mRNA and protein secretion were higher in tumor samples from patients who later developed distant metastasis than in patients who did not. By using distant metastasis as a dependent variable, patients were classified into two categories of IL-1α transcript-levels. The high-IL-1α group had a significantly lower five-year distant metastasis-free survival than the low-IL-1α group [70. 0% (CI 95%: 55. 9-84. 1%) vs 94. 7% (CI 95%:90. 2-99. 2%)]. When IL-1α transcript-levels were combined with clinical factors related to tumor metastasis, the predictive power of the model increased significantly. Additionally, transcript levels of IL-1α correlated significantly with those of the IL-1 family genes and genes related to the metastatic process. IL-1 treatment of microvascular endothelial cells increased adhesion of HNSCC cells but no differences were found based on constitutive IL-1α expression by tumor cells. Nevertheless, IL-1α produced by tumor cells effectively increased their transmigration across the endothelium. We found a significant relationship between IL-1α expression and development of distant metastasis in HNSCC patients. IL-1α expression could help to define a subset of patients at high risk of distant metastasis who could benefit from adjuvant treatment. |
Ajuts: | Instituto de Salud Carlos III FIS/PI14/01918 Instituto de Salud Carlos III SAF2013-46707-R Instituto de Salud Carlos III RD12/0042/0051 |
Nota: | Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER) |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Matèria: | Cap ; Càncer ; Coll ; Head and neck cancer ; IL-1α ; Metastasis ; Prognosis ; Càncer de cap i coll ; Metastasi |
Publicat a: | Oncotarget, Vol. 6 (october 2015) , p. 37398-37409, ISSN 1949-2553 |
12 p, 2.6 MB |