Anti-NF155 chronic inflammatory demyelinating polyradiculoneuropathy strongly associates to HLA-DRB15
Martinez Martinez, Laura (Institut d'Investigació Biomèdica Sant Pau)
Lleixà, Cinta (Institut d'Investigació Biomèdica Sant Pau)
Boera-Carnicero, Gemma (Institut d'Investigació Biomèdica Sant Pau)
Cortese, Andrea (IRCCS Foundation C. Mondino National Neurological Institute (Itàlia))
Devaux, Jérôme (Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille)
Siles, Ana M.. (Institut d'Investigació Biomèdica Sant Pau)
Rajabally, Yusuf (Regional Neuromuscular Clinic, Queen Elizabeth Hospital)
Martínez-Piñeiro, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Carvajal, Alejandra (Hospital Universitario Virgen de las Nieves (Granada))
Pardo, Julio (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Delmont, Emilien (Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille)
Attarian, Shahram
Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Callegari, Ilaria (IRCCS Foundation C. Mondino National Neurological Institute (Itàlia))
Marchioni, Enrico (IRCCS Foundation C. Mondino National Neurological Institute (Itàlia))
Franciotta, Diego (IRCCS Foundation C. Mondino National Neurological Institute (Itàlia))
Benedetti, Luana
Lauria, Giuseppe
Calle Martín, Óscar de la, (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Juarez, Candido (Institut d'Investigació Biomèdica Sant Pau)
Illa, Isabel (Institut d'Investigació Biomèdica Sant Pau)
Querol, Luis
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	Background: The aim of the research is to study the human leukocyte antigen (HLA) class II allele frequencies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) associated with anti-neurofascin 155 (NF155) antibodies. Methods: Thirteen anti-NF155+ and 35 anti-NF155 negative (anti-NF155neg) CIDP patients were included in a casecontrol study. The frequencies of the DRB1 HLA allele were analyzed in all patients while DQ frequencies were only studied in patients sharing the DRB1*15 allele. In silico HLA-peptide binding and NF155 antigenicity, predictions were performed to analyze overlap between presented peptides and antigenic regions. Results: DRB1*15 alleles (DRB1*15:01 and DRB1*15:02) were present in 10 out of 13 anti-NF155+ CIDP patients and in only 5 out of 35 anti-NF155neg CIDP patients (77 vs 14%; OR = 20, CI = 4. 035 to 99. 13). DRB1*15 alleles appeared also in significantly higher proportions in anti-NF155+ CIDP than in normal population (77 vs 17%; OR = 16. 9, CI = 4. 434 to 57. 30). Seven anti-NF155+ CIDP patients (53%) and 5 anti-NF155neg CIDP patients had the DRB1*15:01 allele (OR = 7, p = 0. 009), while 3 anti-NF155+ CIDP patients and none of the anti-NF155neg CIDP patients had the DRB1*15:02 allele (OR = 23. 6, p = 0. 016). In silico analysis of the NF155 peptides binding to DRB1*15 alleles showed significant overlap in the peptides presented by the 15:01 and 15:02 alleles, suggesting functional homology. Conclusions: DRB1*15 alleles are the first strong risk factor associated to a CIDP subset, providing additional evidence that anti-NF155+ CIDP patients constitute a differentiated disease within the CIDP syndrome.
Grants:	Instituto de Salud Carlos III PI16/000627
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	CIDP ; Antibodies ; NF155 ; HLA DRB1*15
Published in:	Journal of neuroinflammation, Vol. 14 Núm. 224 (2017) , p. 1-6, ISSN 1742-2094

DOI: 10.1186/s12974-017-0996-1
PMID: 29145880

6 p, 517.4 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles