Assessment of the influence of direct tobacco smoke on infection and active TB management
Altet, Neus (Hospital Universitari Vall d'Hebron)
Latorre, Irene (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron)
Maldonado, José (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona))
Molina Romero, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona))
González-Díaz, Yoel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona))
Milà, Celia (Hospital Universitari Vall d'Hebron)
García-García, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Muriel-Moreno, Beatriz (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Villar-Hernández, Raquel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Laabei, Maisem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Godoy, Pere (Generalitat de Catalunya. Departament de Salut)
De Souza Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron)
Solano Reina, Segismundo (Hospital General Universitario Gregorio Marañón)
Jiménez-Ruiz, Carlos A. (Comunidad Autónoma de Madrid. Unidad de Tabaquismo)
Domínguez, José (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
PII Smoking SEPAR Working Group

Data:	2017
Resum:	Background. Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. Consequently, an impaired immune response could affect performance of IFN-γ Release Assays (IGRAs). Objective. In the present study, we assess the impact of direct tobacco smoking on radiological manifestations, sputum conversion and immune response to Mycobacterium tuberculosis, analyzing IFN-γ secretion by IGRAs. Methods. A total of 525 participants were studied: (i) 175 active pulmonary TB patients and (ii) 350 individuals coming from contact tracing studies, 41 of whom were secondary TB cases. Clinical, radiological and microbiological data were collected. T-SPOT. TB and QFN-G-IT were processed according manufacturer's instructions. Results. In smoking patients with active TB, QFN-G-IT (34. 4%) and T-SPOT. TB (19. 5%) had high frequencies of negative results. In addition, by means of an unconditional logistic regression,smoking was a main factor associated with IGRAs' false-negative results (aOR: 3. 35; 95% CI:1. 47±7. 61; p<0. 05). Smoking patients with active TB presented a high probability of having cavitary lesions (aOR: 1. 88; 95%CI:1. 02±3. 46;p<0. 05). Mean culture negativization (months) ± standard deviation (SD) was higher in smokers than in non-smokers (2. 47±1. 3 versus 1. 69±1. 4). Latent TB infection (LTBI) was favored in smoking contacts, being a risk factor associated with infection (aOR: 11. 57; 95%CI:5. 97±22. 41; p<0. 00005). The IFN-γ response was significantly higher in non-smokers than in smokers. Smoking quantity and IFN-γ response analyzed by IGRAs were dose-dependent related. Conclusions. Smoking had a negative effect on radiological manifestations, delaying time of sputum conversion. Our data establish a link between tobacco smoking and TB due to a weakened IFN- γ response caused by direct tobacco smoke.
Ajuts:	Instituto de Salud Carlos III PI 13/01546 Instituto de Salud Carlos III PI 16/01912
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 12 Núm. 8 (august 2017) , p. 1, ISSN 1932-6203

DOI: 10.1371/journal.pone.0182998
PMID: 28837570

17 p, 1.5 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Biotecnologia i de Biomedicina (IBB)
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