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Assessment of the influence of direct tobacco smoke on infection and active TB management
Altet, Neus (Hospital Universitari Vall d'Hebron)
Latorre, Irene (Institut d'Investigació Germans Trias i Pujol)
Jiménez-Fuentes, María Ángeles (Hospital Universitari Vall d'Hebron)
Maldonado, José (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona))
Molina, Israel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona))
González-Díaz, Yoel (Unitat Clínica de Tractament Directament Observat de la Tuberculosi (Barcelona))
Milà, Celia (Hospital Universitari Vall d'Hebron)
García-García, Esther (Institut d'Investigació Germans Trias i Pujol)
Muriel, Beatriz (Institut d'Investigació Germans Trias i Pujol)
Villar-Hernández, Raquel (Institut d'Investigació Germans Trias i Pujol)
Laabei, Maisem (Institut d'Investigació Germans Trias i Pujol)
Gómez, Andromeda-Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i Biomedicina)
Godoy, Pere (Generalitat de Catalunya. Departament de Salut)
de Souza-Galvão, Maria Luiza (Hospital Universitari Vall d'Hebron)
Solano, Segismundo (Hospital Universitario Gregorio Marañón)
Jiménez-Ruiz, Carlos A. (Unidad de Tabaquismo de la Comunidad Autónoma de Madrid)
Domínguez, Jose (Institut d'Investigació Germans Trias i Pujol)
PII Smoking SEPAR Working Group

Date: 2017
Abstract: Background. Smoking is a risk factor for tuberculosis (TB) infection and disease progression. Tobacco smoking increases susceptibility to TB in a variety of ways, one of which is due to a reduction of the IFN-γ response. Consequently, an impaired immune response could affect performance of IFN-γ Release Assays (IGRAs). Objective. In the present study, we assess the impact of direct tobacco smoking on radiological manifestations, sputum conversion and immune response to Mycobacterium tuberculosis, analyzing IFN-γ secretion by IGRAs. Methods. A total of 525 participants were studied: (i) 175 active pulmonary TB patients and (ii) 350 individuals coming from contact tracing studies, 41 of whom were secondary TB cases. Clinical, radiological and microbiological data were collected. T-SPOT. TB and QFN-G-IT were processed according manufacturer's instructions. Results. In smoking patients with active TB, QFN-G-IT (34. 4%) and T-SPOT. TB (19. 5%) had high frequencies of negative results. In addition, by means of an unconditional logistic regression,smoking was a main factor associated with IGRAs' false-negative results (aOR: 3. 35; 95% CI:1. 47±7. 61; p<0. 05). Smoking patients with active TB presented a high probability of having cavitary lesions (aOR: 1. 88; 95%CI:1. 02±3. 46;p<0. 05). Mean culture negativization (months) ± standard deviation (SD) was higher in smokers than in non-smokers (2. 47±1. 3 versus 1. 69±1. 4). Latent TB infection (LTBI) was favored in smoking contacts, being a risk factor associated with infection (aOR: 11. 57; 95%CI:5. 97±22. 41; p<0. 00005). The IFN-γ response was significantly higher in non-smokers than in smokers. Smoking quantity and IFN-γ response analyzed by IGRAs were dose-dependent related. Conclusions. Smoking had a negative effect on radiological manifestations, delaying time of sputum conversion. Our data establish a link between tobacco smoking and TB due to a weakened IFN- γ response caused by direct tobacco smoke.
Note: Número d'acord de subvenció ISCIII/PI 13/01546
Note: Número d'acord de subvenció ISCIII/PI 16/01912
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Published in: Plos one, Vol. 12 Núm. 8 (august 2017) , p. 1

DOI: 10.1371/journal.pone.0182998
PMID: 28837570

17 p, 1.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles

 Record created 2018-10-25, last modified 2019-10-01

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