Antibodies against peripheral nerve antigens in chronic inflammatory demyelinating polyradiculoneuropathy
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau)
Siles, Ana M.. (Institut d'Investigació Biomèdica Sant Pau)
Alba-Rovira, Roser (Institut d'Investigació Biomèdica Sant Pau)
Jáuregui, Agustín (Fundación Favaloro, Buenos, Aires, Argentina)
Devaux, Jérôme (Aix-Marseille Université)
Faivre-Sarrailh, Catherine (Aix-Marseille Université)
Araque, Josefa (Institut d'Investigació Biomèdica Sant Pau)
Rojas-Garcia, Ricard (Institut d'Investigació Biomèdica Sant Pau)
Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Cortés-Vicente, Elena (Institut d'Investigació Biomèdica Sant Pau)
Nogales, Gisela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Navas Madroñal, Miquel (Institut d'Investigació Biomèdica Sant Pau)
Gallardo, Eduard (Institut d'Investigació Biomèdica Sant Pau)
Illa, Isabel (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a heterogeneous disease in which diverse autoantibodies have been described but systematic screening has never been performed. Detection of CIDP-specific antibodies may be clinically useful. We developed a screening protocol to uncover novel reactivities in CIDP. Sixty-five CIDP patients and 28 controls were included in our study. Three patients (4. 6%) had antibodies against neurofascin 155, four (6. 2%) against contactin-1 and one (1. 5%) against the contactin-1/contactin-associated protein-1 complex. Eleven (18. 6%) patients showed anti-ganglioside antibodies, and one (1. 6%) antibodies against peripheral myelin protein 2. No antibodies against myelin protein zero, contactin-2/contactin-associated protein-2 complex, neuronal cell adhesion molecule, gliomedin or the voltage-gated sodium channel were detected. In IgG experiments, three patients (5. 3%) showed a weak reactivity against motor neurons; 14 (24. 6%) reacted against DRG neurons, four of them strongly (7. 0%), and seven (12. 3%) reacted against Schwann cells, three of them strongly (5. 3%). In IgM experiments, six patients (10. 7%) reacted against DRG neurons, while three (5. 4%) reacted against Schwann cells. However, results were not statistically significant when compared to controls. Immunoprecipitation experiments identified CD9 and L1CAM as potential antigens, but reactivity could not be confirmed with cell-based assays. In summary, we describe a diverse autoantibody repertoire in CIDP patients, reinforcing the hypothesis of CIDP's pathophysiological heterogeneity.
Grants:	Instituto de Salud Carlos III FIS13/00937 Instituto de Salud Carlos III FIS16/00627
Note:	Altres ajuts: Beca Juan Rodes JR1300014
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Scientific reports, Vol. 7 (october 2017) , p. 1-9, ISSN 2045-2322

DOI: 10.1038/s41598-017-14853-4
PMID: 29089585

9 p, 1.2 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles