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Antibodies against peripheral nerve antigens in chronic inflammatory demyelinating polyradiculoneuropathy
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau)
Siles, Ana M (Institut d'Investigació Biomèdica Sant Pau)
Alba-Rovira, Roser (Institut d'Investigació Biomèdica Sant Pau)
Jáuregui, Agustín (Fundación Favaloro, Buenos, Aires, Argentina)
Devaux, Jérôme (Aix-Marseille Université)
Faivre-Sarrailh, Catherine (Aix-Marseille Université)
Araque, Josefa (Institut d'Investigació Biomèdica Sant Pau)
Rojas Garcia,Ricard (Institut d'Investigació Biomèdica Sant Pau)
Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Cortés Vicente, Elena (Institut d'Investigació Biomèdica Sant Pau)
Nogales Gadea,Gisela (Institut Germans Trias i Pujol)
Navas Madroñal, Miquel (Institut d'Investigació Biomèdica Sant Pau)
Gallardo Vigo, Eduard (Institut d'Investigació Biomèdica Sant Pau)
Illa, Isabel (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date: 2017
Abstract: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a heterogeneous disease in which diverse autoantibodies have been described but systematic screening has never been performed. Detection of CIDP-specific antibodies may be clinically useful. We developed a screening protocol to uncover novel reactivities in CIDP. Sixty-five CIDP patients and 28 controls were included in our study. Three patients (4. 6%) had antibodies against neurofascin 155, four (6. 2%) against contactin-1 and one (1. 5%) against the contactin-1/contactin-associated protein-1 complex. Eleven (18. 6%) patients showed anti-ganglioside antibodies, and one (1. 6%) antibodies against peripheral myelin protein 2. No antibodies against myelin protein zero, contactin-2/contactin-associated protein-2 complex, neuronal cell adhesion molecule, gliomedin or the voltage-gated sodium channel were detected. In IgG experiments, three patients (5. 3%) showed a weak reactivity against motor neurons; 14 (24. 6%) reacted against DRG neurons, four of them strongly (7. 0%), and seven (12. 3%) reacted against Schwann cells, three of them strongly (5. 3%). In IgM experiments, six patients (10. 7%) reacted against DRG neurons, while three (5. 4%) reacted against Schwann cells. However, results were not statistically significant when compared to controls. Immunoprecipitation experiments identified CD9 and L1CAM as potential antigens, but reactivity could not be confirmed with cell-based assays. In summary, we describe a diverse autoantibody repertoire in CIDP patients, reinforcing the hypothesis of CIDP's pathophysiological heterogeneity.
Note: Altres ajuts: Beca Juan Rodes JR1300014
Note: Número d'acord de subvenció FIS/FIS13/00937
Note: Número d'acord de subvenció FIS/FIS16/00627
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Published in: Sientific reports, Vol. 7 (october 2017) , p. 1-9

DOI: 10.1038/s41598-017-14853-4
PMID: 29089585

9 p, 1.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2018-10-26, last modified 2020-11-23

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