Web of Science: 6 citations, Scopus: 5 citations, Google Scholar: citations
ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer
Cedó, Lidia (Institut d'Investigació Biomèdica Sant Pau)
García León, Annabel (Institut d'Investigacions Biomèdiques Sant Pau)
Baila Rueda, Lucía (Hospital Universitario Miguel Servet)
Santos, David (Institut d'Investigacions Biomèdiques Sant Pau)
Grijalva, Victor (University of California. Department of Medicine)
Martínez Cignoni, Melanie Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Carbó, José María (Universitat de Barcelona)
Metso, Jari (Minerva Foundation Institute for Medical Research)
López Vilaró, Laura (Institut d'Investigacions Biomèdiques Sant Pau)
Zorzano Olarte, Antonio (Institute for Research in Biomedicine)
Valledor, Annabel F. (Universitat de Barcelona)
Cenarro, Ana (Hospital Universitario Miguel Servet)
Jauhiainen, Matti (Minerva Foundation Institute for Medical Research)
Lerma Puertas, Enrique (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques)
Fogelman, Alan M. (University of California. Department of Medicine)
Reddy, Srinivasa T. (University of California. Department of Medicine)
Escolà-Gil, Joan Carles (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Blanco Vaca, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)

Date: 2016
Abstract: Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification.
Note: Número d'acord de subvenció ISCIII/PI11/01076
Note: Número d'acord de subvenció ISCIII/PI12/00291
Note: Número d'acord de subvenció ISCIII/PI13/02507
Note: Número d'acord de subvenció ISCIII/RD12-0042-0055
Note: Número d'acord de subvenció MINECO/SAF2011-23402
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès.
Document: article ; recerca ; publishedVersion
Subject: Animals ; Antineoplastic Agents ; Apolipoprotein A-I ; Breast Neoplasms ; Cell Proliferation ; Cell Survival ; Female ; Humans ; Lipoproteins, LDL ; MCF-7 Cells ; Mice ; Mice, Transgenic ; Molecular Mimicry ; Peptides ; Xenograft Model Antitumor Assays
Published in: Scientific Reports, Vol. 6 (November 2016) , art. 36387, ISSN 2045-2322

PMID: 27808249
DOI: 10.1038/srep36387


11 p, 1.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació Biomèdica Sant Pau
Articles > Research articles
Articles > Published articles

 Record created 2019-04-04, last modified 2019-04-30



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