Web of Science: 2 cites, Scopus: 2 cites, Google Scholar: cites,
Genomic analysis of the origins of extant casein variation in goats
Guan, Dailu (Centre de Recerca en Agrigenòmica)
Mármol-Sánchez, Emilio (Centre de Recerca en Agrigenòmica)
Cardoso, Tainã Figueiredo (Centre de Recerca en Agrigenòmica)
Such i Martí, Francesc Xavier (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Landi, Vincenzo (Universidad de Córdoba. Departamento de Genética)
Tawari, N. R. (Genome Institute of Singapore. Computational and Systems Biology)
Amills i Eras, Marcel (Centre de Recerca en Agrigenòmica)

Data: 2019
Resum: The variation in the casein genes has a major impact on the milk composition of goats. Even though many casein polymorphisms have been identified so far, we do not know yet whether they are evolutionarily ancient (i. e. , they existed before domestication) or young (i. e. , they emerged after domestication). Herewith, we identified casein polymorphisms in a data set of 106 caprine whole-genome sequences corresponding to bezoars (Capra aegagrus, the ancestor of domestic goats) and 4 domestic goat (Capra hircus) populations from Europe, Africa, the Far East, and the Near East. Domestic and wild goat populations shared a substantial number of casein SNP, from 36. 1% (CSN2) to 55. 1% (CSN1S2). The comparison of casein variation among bezoars and the 4 domestic goat populations demonstrated that more than 50% of the casein SNP are shared by 2 or more populations, and 18 to 44% are shared by all populations. Moreover, the majority of casein alleles reported in domestic goats also segregate in the bezoar, including several alleles displaying significant associations with milk composition (e. g. , the A/B alleles of the CSN1S1 and CSN3 genes, the A allele of the CSN2 gene). We conclude that much of the current diversity of the caprine casein genes comes from ancient standing variation segregating in the ancestor of modern domestic goats.
Nota: Número d'acord de subvenció MINECO/AGL2016-76108-R
Nota: Número d'acord de subvenció MINECO/SEV-2015-0533
Nota: Número d'acord de subvenció MECD/FPU15/01733
Drets: Tots els drets reservats
Llengua: Anglès
Document: article ; recerca ; Versió acceptada per publicar
Matèria: Domestication ; Standing variation ; Next-generation sequencing ; Single nucleotide polymorphism
Publicat a: Journal of dairy science, Vol. 102, issue 6 (June 2019) , p. 5230-5241, ISSN 1525-3198

DOI: 10.3168/jds.2018-15281

65 p, 2.7 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > CRAG (Centre de Recerca en Agrigenòmica)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2020-04-15, darrera modificació el 2021-06-06

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