Web of Science: 3 citations, Scopus: 4 citations, Google Scholar: citations,
IMKT : the integrative McDonald and Kreitman test
Murga Moreno, Jesús (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Coronado-Zamora, Marta (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Hervas Fernández, Sergi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasi")
Casillas Viladerrams, Sònia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasi")
Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Date: 2019
Abstract: The McDonald and Kreitman test (MKT) is one of the most powerful and widely used methods to detect and quantify recurrent natural selection using DNA sequence data. Here we present iMKT (acronym for integrative McDonald and Kreitman test), a novel web-based service performing four distinct MKT types. It allows the detection and estimation of four different selection regimes -adaptive, neutral, strongly deleterious and weakly deleterious- acting on any genomic sequence. iMKT can analyze both user's own population genomic data and pre-loaded Drosophila melanogaster and human sequences of protein-coding genes obtained from the largest population genomic datasets to date. Advanced options in the website allow testing complex hypotheses such as the application example showed here: do genes located in high recombination regions undergo higher rates of adaptation? We aim that iMKT will become a reference site tool for the study of evolutionary adaptation in massive population genomics datasets, especially in Drosophila and humans. iMKT is a free resource online at https://imkt. uab. cat.
Note: Número d'acord de subvenció MINECO/CGL2017-89160P
Note: Número d'acord de subvenció AGAUR/2017/SGR-1379
Note: Número d'acord de subvenció AGAUR/FI-DGR2015
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; recerca ; publishedVersion
Subject: Adaptation, Physiological ; Alleles ; Animals ; Biological evolution ; Datasets as Topic ; Drosophila melanogaster ; Gene frequency ; Genome ; Humans ; Metagenomics ; Polymorphism, Genetic ; Recombination, Genetic ; Selection, Genetic ; Sequence Analysis, DNA
Published in: Nucleic acids research, Vol. 47, issue W1 (Jan. 2019) , p. W283-W288, ISSN 1362-4962

DOI: 10.1093/nar/gkz372
PMID: 31081014


6 p, 700.6 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles

 Record created 2020-06-03, last modified 2020-09-07



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