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Comparing the diversity of the casein genes in the Asian mouflon and domestic sheep
Mármol-Sánchez, Emilio (Centre de Recerca en Agrigenòmica)
Luigi Sierra, Maria Gracia (Centre de Recerca en Agrigenòmica)
Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Data: 2020
Resum: We aimed to determine whether casein variants that are currently segregating in ovine populations existed before the domestication of sheep or, to the contrary, if their emergence is much more recent. To this end, we have retrieved whole-genome sequences from Iranian and domestic sheep from Africa, Europe, South and East Asia and West Asia. Population structure analysis based on 55,352,935 SNPs revealed a clear separation between Iranian mouflons and domestic sheep. Moreover, we also observed a strong genetic differentiation between Iranian mouflons sampled in geographic areas close to Tehran and Tabriz. Based on sequence data, hundreds of SNPs mapping to the casein αS1 (CSN1S1, 248 SNPs), casein αS2 (CSN1S2, 268 SNPs), casein ß (CSN2, 146 SNPs) and casein κ (CSN3, 112 SNPs) genes were identified. Approximately 25-63. 02% of the casein variation was shared between Iranian mouflons and domestic sheep, and the four domestic sheep populations also shared 44. 2-57. 4% of the casein polymorphic sites. These findings suggest that an important fraction of the casein variation present in domestic sheep was already segregating in the mouflon prior to its domestication. Genomic studies performed in horses and dogs are consistent with this view, suggesting that much of the diversity that we currently detect in domestic animals comes from standing variation already segregating in their wild ancestors.
Ajuts: European Commission 244356
Ministerio de Economía y Competitividad BES-C-2017-079709
Ministerio de Educación y Ciencia FPU15-01733
Ministerio de Economía y Competitividad SEV-2015-0533
Nota: Availability of the Data: The whole-genome SNP datasets used in this research are available in Figshare. The accession numbers are 10.6084/m9.figshare.11663598.v1, 10.6084/m9.figshare.11686809.v1, 10.6084/m9.figshare.11686962.v1, 10.6084/m9.figshare.11687118.v1, 10.6084/m9.figshare.11688276.v1 and 10.6084/m9.figshare.11688600.v2. Furthermore, VCF containing the SNPs mapping to the ovine casein genes can be found at 10.6084/m9.figshare.11663547.v1
Drets: Tots els drets reservats
Llengua: Anglès
Document: Article ; recerca ; Versió acceptada per publicar
Matèria: Casein genes ; Domestication ; Mouflon ; Sheep
Publicat a: Animal Genetics, Vol. 51, Issue 3 (June 2020) , p. 470-475, ISSN 1365-2052

DOI: 10.1111/age.12937
PMID: 32281138


Postprint
18 p, 1.6 MB

Supplementary material
38 p, 2.3 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > CRAG (Centre de Recerca en Agrigenòmica)
Articles > Articles de recerca
Articles > Articles publicats

 Registre creat el 2020-06-09, darrera modificació el 2022-03-03



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