Epigenetic-smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients
Ji, Xinyu (Nanjing Medical University. Department of Biostatistics)
Lin, Lijuan (Nanjing Medical University. Department of Biostatistics)
Shen, Sipeng (Nanjing Medical University. Department of Biostatistics)
Dong, Xuesi (Nanjing Medical University. Department of Biostatistics)
Chen, Chao (Nanjing Medical University. Department of Biostatistics)
Li, Yi (University of Michigan. Department of Biostatistics)
Zhu, Ying (Nanjing Medical University. Department of Biostatistics)
Huang, Hui (Nanjing Medical University. Department of Biostatistics)
Chen, Jiajin (Nanjing Medical University. Department of Biostatistics)
Chen, Xin (Nanjing Medical University. Department of Biostatistics)
Wei, Liangmin (Nanjing Medical University. Department of Biostatistics)
He, Jieyu (Nanjing Medical University. Department of Biostatistics)
Duan, Weiwei (Nanjing Medical University. Department of Biostatistics)
Su, Li (Harvard T.H. Chan School of Public Health. Department of Environmental Health)
Jiang, Yue (Nanjing Medical University. Department of Biostatistics)
Fan, Juanjuan (Nanjing Medical University. Department of Biostatistics)
Guan, Jinxing (Nanjing Medical University. Department of Biostatistics)
You, Dongfang (Harvard T.H. Chan School of Public Health. Department of Environmental Health)
Shafer, Andrea (Harvard Medical School)
Bjaanæs, Maria Moksnes (Oslo University Hospital. Department of Cancer Genetics)
Karlsson, Anna (Lund University. Department of Clinical Sciences Lund)
Planck, Maria (Lund University. Department of Clinical Sciences Lund)
Staaf, Johan (Lund University. Department of Clinical Sciences Lund)
Helland, Åslaug (Oslo University Hospital. Department of Cancer Genetics)
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Wei, Yongyue (Nanjing Medical University. Department of Biostatistics)
Zhang, Ruyang (Nanjing Medical University. Department of Biostatistics)
Chen, Feng (Nanjing Medical University. Department of Biostatistics)
Christiani, David C (Harvard Medical School)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylation of TRIM27 and overall survival. Significant CpG probes were confirmed in 617 samples from The Cancer Genome Atlas. The methylation of the CpG probe cg05293407 was significantly associated with overall survival in patients with LUSC (HR = 1. 65, 95% CI: 1. 30-2. 09, P = 4. 52 × 10), but not in patients with LUAD (HR = 1. 08, 95% CI: 0. 87-1. 33, P = 0. 493). As incidence of LUSC is associated with higher smoking intensity compared to LUAD, we investigated whether smoking intensity impacted on the prognostic effect of cg05293407 methylation in NSCLC. LUSC patients had a higher average pack-year of smoking (37. 49 vs 54. 79, P = 1. 03 × 10) and included a higher proportion of current smokers than LUAD patients (28. 24% vs 34. 09%, P = 0. 037). cg05293407 was significantly associated with overall survival only in NSCLC patients with medium-high pack-year of smoking (HR = 1. 58, 95% CI: 1. 26-1. 96, P = 5. 25 × 10). We conclude that cg05293407 methylation is a potential predictor of LUSC prognosis, and smoking intensity may impact on its prognostic value across the various types of NSCLC.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	TRIM27 ; DNA methylation ; Interaction ; Non-small-cell lung cancer ; Overall survival ; Prognosis
Publicat a:	Molecular oncology, Vol. 14 Núm. 11 (january 2020) , p. 2759-2774, ISSN 1878-0261

DOI: 10.1002/1878-0261.12785
PMID: 33448640

16 p, 1.9 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Institut de Recerca contra la Leucèmia Josep Carreras
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