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1.
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Spatial variation and controls of soil microbial necromass carbon in a tropical montane rainforest
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Ding, Zhangqi (Chinese Academy of Sciences. South China Botanical Garden) ;
Mou, Zhijian (Chinese Academy of Sciences. South China Botanical Garden) ;
Li, Yanpeng (Chinese Academy of Forestry. Research Institute of Tropical Forestry) ;
Liang, Chao (Chinese Academy of Sciences. Institute of Applied Ecology) ;
Xie, Zicai (Chinese Academy of Sciences. South China Botanical Garden) ;
Wang, Jun (Chinese Academy of Sciences. South China Botanical Garden) ;
Hui, Dafeng (Tennessee State University. Department of Biological Sciences) ;
Lambers, Hans (University of Western Australia. School of Biological Sciences) ;
Sardans i Galobart, Jordi (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Xu, Han (Chinese Academy of Forestry. Research Institute of Tropical Forestry) ;
Liu, Zhanfeng (Chinese Academy of Sciences. South China Botanical Garden)
Soil microbial necromass carbon is an important component of the soil organic carbon (SOC) pool which helps to improve soil fertility and texture. However, the spatial pattern and variation mechanisms of fungal- and bacterial-derived necromass carbon at local scales in tropical rainforests are uncertain. [...]
2024 -  10.1016/j.scitotenv.2024.170986
Science of the total environment, Vol. 921 (April 2024) , art. 170986
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2.
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Cross-scale spatial variability and associations of carbon pools provide insight into regulating carbon sequestration in tropical montane rainforests
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Ding, Zhangqi Ding (Chinese Academy of Sciences. South China Botanical Garden) ;
Mou, Zhijian (Chinese Academy of Sciences. South China Botanical Garden) ;
Li, Yanpeng (Chinese Academy of Forestry. Research Institute of Tropical Forestry) ;
Wang, Jun (Chinese Academy of Sciences. South China Botanical Garden) ;
Wu, Donghai (Chinese Academy of Sciences. South China Botanical Garden) ;
Liang, Chao (Chinese Academy of Sciences. Institute of Applied Ecology) ;
Hui, Dafeng (Tennessee State University. Department of Biological Sciences) ;
Sardans i Galobart, Jordi (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Xu, Han (Chinese Academy of Forestry. Research Institute of Tropical Forestry) ;
Liu, Zhanfeng (Chinese Academy of Sciences. South China Botanical Garden)
The spatial distribution of plant, soil, and microbial carbon pools, along with their intricate interactions, presents a great challenge for the current carbon cycle research. However, it is not clear what are the characteristics of the spatial variability of these carbon pools, particularly their cross-scale relationships. [...]
2024 - 10.1016/j.jenvman.2024.120288
Journal of environmental management, Vol. 353 (February 2024) , art. 120288
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3.
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12 p, 963.9 KB |
Mechanical ventilation in patients with cardiogenic pulmonary edema : a sub-analysis of the LUNG SAFE study
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Amado-Rodríguez, Laura (Centro de Investigación Biomédica en Red (CIBER)-Enfermedades Respiratorias) ;
Rodríguez-Garcia, Raquel (Centro de Investigación Biomédica en Red (CIBER)-Enfermedades Respiratorias) ;
Albaiceta, Guillermo M. ;
Pham, Tài (Université Paris-Saclay) ;
Fan, Eddy (University of Toronto) ;
Madotto, Fabiana (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico) ;
Laffey, John G. ;
Pesenti, A. ;
Brochard, L. ;
Esteban, A. ;
Gattinoni, Luciano ;
Van Haren, Frank ;
Larsson, Anders ;
McAuley, Daniel F. ;
Ranieri, Marco ;
Rubenfeld, Gordon ;
Taylor Thompson, B. ;
Wrigge, Hermann ;
Slutsky, Arthur S. ;
Rios, Fernando ;
Van Haren, Frank ;
Sottiaux, Thierry ;
Depuydt, Pieter ;
Lora, Fredy S. ;
Azevedo, Luciano Cesar ;
Bugedo, Guillermo ;
Qiu, Haibo ;
Gonzalez, Marcos ;
Silesky, Juan ;
Cerny, Vladimir ;
Nielsen, Jonas ;
Jibaja, Manuel ;
Wrigge, Hermann ;
Matamis, Dimitrios ;
Ranero, Jorge Luis ;
Amin, Pravin ;
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Clarkson, Kevin ;
Kurahashi, Kyyoyasu ;
Villagomez, Asisclo ;
Zeggwagh, Amine Ali 700 1_ ;
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Palo, Jose Emmanuel ;
do Vale Fernandes, Antero ;
Sandesc, Dorel ;
Arabi, Yaasen. ;
Bumbasierevic, Vesna ;
Nin, Nicolas ;
Lorente, Jose A. ;
Larsson, Anders ;
Piquilloud, Lise ;
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Bajwa, Ed ;
Démpaire, Gabriel ;
Sula, Hektor ;
Nunci, Lordian ;
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Zazu, Alan ;
Dellera, Christian ;
Insaurralde, Carolina S. ;
Las Lomas, Sanatorio ;
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Alejandro, Risso V. ;
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Vercueil, A. ;
Bhowmick, K. ;
Humphreys, S.K. ;
Ferguson, A. ;
Mckee, R. ;
Raj, A.S. ;
Fawkes, D.A. ;
Watt, P. ;
Twohey, L. ;
Jha, R.R. ;
Thomas, M. ;
Morton, A. ;
Kadaba, V. ;
Smith, M.J. ;
Hormis, A.P. ;
Kannan, S.G. ;
Namih, M. ;
Reschreiter, H. ;
Camsooksai, J. ;
Kumar, A. ;
Rugonfalvi, S. ;
Nutt, C. ;
Oneill, O. ;
Seasman, C. ;
Dempsey, G. ;
Scott, C.J. ;
Ellis, H.E. ;
Mckechnie, S. ;
Hutton, P.J. ;
Di Tomasso, N.N. ;
Vitale, M.N. ;
Griffin, R.O. ;
Dean, M.N. ;
Cranshaw, J.H. ;
Willett, E.L. ;
Ioannou, N. ;
Gillis, S. ;
Csabi, P. ;
Macfadyen, R. ;
Dawson, H. ;
Preez, P.D. ;
Williams, A.J. ;
Boyd, O. ;
de Gordoa, L.O.R. ;
Bramall, J. ;
Symmonds, S. ;
Chau, S.K. ;
Wenham, T. ;
Szakmany, T. ;
Toth-Tarsoly, P. ;
McCalman, K.H. ;
Alexander, P. ;
Stephenson, L. ;
Collyer, T. ;
Chapman, R. ;
Cooper, R. ;
Allan, R.M. ;
Sim, M. ;
Wrathall, D.W. ;
Irvine, D.A. ;
Zantua, C.K.S. ;
Adams, J.C. ;
Burtenshaw, A.J. ;
Sellors, G.P. ;
Welters, I.D. ;
Williams, K.E. ;
Hessell, R.J. ;
Oldroyd, M.G. ;
Battle, C.E. ;
Pillai, S. ;
Kajtor, I. ;
Sivashanmugavel, M. ;
Okane, S.C. ;
Donnelly, A. ;
Frigyik, A.D. ;
Careless, J.P. ;
May, M.M. ;
Stewart, R. ;
Trinder, T.J. ;
Hagan, S.J. ;
Cole, J.M. ;
MacFie, C.C. ;
Dowling, A.T. ;
Hurtado, J. ;
Nin, N. ;
Hurtado, J. ;
Nuñez, E. ;
Pittini, G. ;
Rodriguez, R. ;
Imperio, M.C. ;
Santos, C. ;
França, A.G. ;
Ebeid, A. ;
Deicas, A. ;
Serra, C. ;
Uppalapati, A. ;
Kamel, G. ;
BannerGoodspeed, V.M. ;
Beitler, J.R. ;
Mukkera, S.R. ;
Kulkarni, S. ;
Shinn, J.O. ;
Gomaa, D. ;
Tainter, C. ;
Lee, J. ;
Mesar, T. ;
Yeatts, D.J. ;
Warren, J. ;
Lanspa, M.J. ;
Miller, R.R. ;
Grissom, C.K. ;
Brown, S.M. ;
Bauer, P.R. ;
Gosselin, R.J. ;
Kitch, B.T. ;
Cohen, J.E. ;
Beegle, S.H. ;
Choudry, S. ;
Gueret, R.M. ;
Tulaimat, A. ;
Stigler, W. ;
Batra, H. ;
Huff, N.G. ;
Lamb, K.D. ;
Oetting, T.W. ;
Mohr, N.M. ;
Judy, C. ;
Saito, S. ;
Kheir, F.M. ;
Kheir, F. ;
Schlichting, A.B. ;
Delsing, A. ;
Crouch, D.R. ;
Elmasri, M. ;
Crouch, D.R. ;
Ismail, D. ;
Dreyer, K.R. ;
Blakeman, T.C. ;
Gomaa, D. ;
Baro, R.M. ;
Hou, P.C. ;
Seethala, R. ;
Aisiku, I. ;
Henderson, G. ;
Frendl, G. ;
Hou, S.K. ;
Owens, R.L. ;
Schomer, A. ;
Universitat Autònoma de Barcelona
Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. [...]
2022 - 10.1186/s40560-022-00648-x
Journal of Intensive Care, Vol. 10 Núm. 1 (01 2022) , p. 55
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4.
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15 p, 1.6 MB |
A trans-omics assessment of gene-gene interaction in early-stage NSCLC
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Chen, Jiajin (Nanjing Medical University) ;
Song, Yunjie (Department of Biostatistics. Nanjing Medical University) ;
Li, Yi (Department of Biostatistics. University of Michigan) ;
Wei, Yongyue (Nanjing Medical University) ;
Shen, Sipeng (Department of Biostatistics. Nanjing Medical University) ;
Zhao, Yang (Department of Biostatistics. Nanjing Medical University) ;
You, Dongfang (Department of Biostatistics. Nanjing Medical University) ;
Su, Li (Harvard Medical School) ;
Bjaanæs, Maria Moksnes (Department of Cancer Genetics Oslo University Hospital) ;
Karlsson, Anna (Department of Clinical Sciences. Lund University) ;
Planck, Maria (Department of Clinical Sciences. Lund University) ;
Staaf, Johan (Department of Clinical Sciences. Lund University) ;
Helland, Åslaug (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M (Universitat de Barcelona) ;
Shen, Hongbing (Nanjing Medical University) ;
Christiani, David C. (Harvard Medical School) ;
Zhang, Ruyang (Nanjing Medical University) ;
Chen, Feng (State Key Laboratory of Reproductive Medicine. Nanjing Medical University)
Epigenome-wide gene-gene (G × G) interactions associated with non-small-cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three-step analytic strategy to identify significant and robust G × G interactions that are relevant to NSCLC survival. [...]
2023 - 10.1002/1878-0261.13345
Molecular Oncology, Vol. 17 Núm. 1 (january 2023) , p. 173-187
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5.
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37 p, 20.5 MB |
Epigenetic regulation during cancer transitions across 11 tumour types
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Terekhanova, Nadezhda V. (Washington University in St Louis) ;
Karpova, Alla (Washington University in St Louis) ;
Liang, Wen Wei (Washington University in St Louis) ;
Strzalkowski, Alexander (Department of Computer Science. Princeton University) ;
Chen, Siqi (Washington University in St Louis) ;
Li, Yize (Washington University in St Louis) ;
Southard-Smith, Austin N. (Washington University in St Louis) ;
Iglesia, Michael D. (Washington University in St Louis) ;
Wendl, Michael C. (Washington University in St Louis) ;
Jayasinghe, Reyka G. (Washington University in St Louis) ;
Liu, Jingxian (Washington University in St Louis) ;
Song, Yizhe (Washington University in St Louis) ;
Cao, Song (Washington University in St Louis) ;
Houston, Andrew (Washington University in St Louis) ;
Liu, Xiuting (Department of Medicine. Washington University in St Louis) ;
Wyczalkowski, Michael A. (Washington University in St Louis) ;
Lu, Rita Jui-Hsien (Washington University in St Louis) ;
Caravan, Wagma (Washington University in St Louis) ;
Shinkle, Andrew (Department of Medicine. Washington University in St Louis) ;
Naser Al Deen, Nataly (Washington University in St Louis) ;
Herndon, John M. (Washington University in St Louis) ;
Mudd, Jacqueline (Department of Surgery. Washington University in St Louis) ;
Ma, Cong (Department of Computer Science. Princeton University) ;
Sarkar, Hirak (Department of Computer Science. Princeton University) ;
Sato, Kazuhito (Washington University in St Louis) ;
Ibrahim, Omar.M. (Washington University in St Louis) ;
Mo, Chia-Kuei (Washington University in St Louis) ;
Chasnoff, Sara E. (Washington University in St Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Held, Jasson M. (Washington University in St Louis) ;
Pachynski, Russell (Washington University in St Louis) ;
Schwarz, Julie K. (Department of Radiation Oncology. Washington University in St Louis) ;
Gillanders, William E. (Washington University in St Louis) ;
Kim, Albert H. (Department of Neurological Surgery. Washington University in St Louis) ;
Vij, Ravi (Washington University in St Louis) ;
DiPersio, John.F. (Washington University in St Louis) ;
Puram, Sidharth V. (Department of Otolaryngology-Head & Neck Surgery. Washington University in St Louis) ;
Chheda, Milan G. (Washington University in St Louis) ;
Fuh, Katherine C. (Department of Obstetrics and Gynecology. Washington University in St Louis) ;
DeNardo, David G. (Washington University in St Louis) ;
Fields, Ryan C. (Washington University in St Louis) ;
Chen, Feng (Washington University in St Louis) ;
Raphael, Benjamin J. (Department of Computer Science. Princeton University) ;
Ding, Li (Department of Genetics. Washington University in St Louis)
Chromatin accessibility is essential in regulating gene expression and cellular identity, and alterations in accessibility have been implicated in driving cancer initiation, progression and metastasis. [...]
2023 - 10.1038/s41586-023-06682-5
Nature, Vol. 623 Núm. 7986 (september 2023) , p. 432-441
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6.
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11 p, 1.9 MB |
Many people with chronic lymphocytic leukemia or small lymphocytic lymphoma benefit from ibrutinib treatment up to 8 years : a plain language summary
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Barr, Paul M. (University of Rochester Medical Center, USA) ;
Owen, Carolyn (University of Calgary, Canada) ;
Robak, Tadeusz (Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland) ;
Tedeschi, Alessandra (ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy) ;
Bairey, Osnat (Rabin Medical Center, Petah Tikva, Israel) ;
Burger, Jan A (University of Texas MD Anderson Cancer Center, Houston, USA) ;
Hillmen, Peter (The Leeds Teaching Hospitals, St James Institute of Oncology, Leeds, UK) ;
Dearden, Claire (The Royal Marsden Hospital, London, UK) ;
Grosicki, Sebastian (Silesian Medical University, Katowice, Poland) ;
McCarthy, Helen (Royal Bournemouth General Hospital (Dorset, Regne Unit)) ;
Li, Jian Yong (Jiangsu Province Hospital, Nanjing, China) ;
Offner, Fritz (Universitair Ziekenhuis Gent, Belgium) ;
Moreno, Carol (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Jermain, Mandy (Pharmacyclics LLC, an AbbVie Company, South San Francisco, USA) ;
Zhou, Cathy (Pharmacyclics LLC, an AbbVie Company, South San Francisco, USA) ;
Hsu, Emily (Pharmacyclics LLC, an AbbVie Company, South San Francisco, USA) ;
Szoke, Anita (Pharmacyclics LLC, an AbbVie Company, South San Francisco, USA) ;
Kipps, Thomas J. (UCSD Moores Cancer Center, San Diego, USA) ;
Ghia, Paolo (Università Vita-Salute San Raffaele &IRCCS Ospedale San Raffaele, Milan, Italy)
What is this summary about? This is a plain language summary of a publication describing long-term results from the RESONATE-2 study with up to 8 years of follow-up. The original paper was published in Blood Advances in June 2022. [...]
2022 - 10.2217/fon-2022-0898
Future oncology (London, England), Vol. 18 Núm. 37 (january 2022)
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7.
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11 p, 771.0 KB |
Do GWAS-Identified Risk Variants for Chronic Lymphocytic Leukemia Influence Overall Patient Survival and Disease Progression?
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Cabrera Serrano, Antonio José (Instituto de Investigación Sanitaria de Granada) ;
Sánchez Maldonado, José Manuel (Instituto de Investigación Sanitaria de Granada) ;
ter Horst, Rob (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences) ;
Macauda, Angelica (German Cancer Research Center) ;
García Martín, Paloma (Hospital Campus de la Salud (Granada)) ;
Benavente, Yolanda (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Landi, Stefano (Department of Biology. University of Pisa) ;
Clay-Gilmour, Alyssa (Department of Epidemiology & Biostatistics. Arnold School of Public Health. University of South Carolina) ;
Niazi, Yasmeen (Hopp Children's Cancer Center) ;
Espinet, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodriguez-Sevilla, Juan Jose (Department of Leukemia. The University of Texas MD Anderson Cancer Center) ;
Pérez, Eva María (Hospital Campus de la Salud) ;
Maffei, Rossana (University of Modena and Reggio Emilia) ;
Blanco, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Giaccherini, Matteo (Department of Biology. University of Pisa) ;
Cerhan, James R. (Department of Quantitative Health Sciences. Mayo Clinic) ;
Marasca, Roberto (Department of Medical and Surgical Sciences. University of Modena and Reggio Emilia. AOU Policlinico) ;
Lopez Nevot, Miguel Angel (Hospital Universitario Virgen de las Nieves (Granada)) ;
Chen-Liang, Tzu Hua (Hospital Universitario Morales Meseguer (Múrcia)) ;
Thomsen, Hauke (MSB Medical School Berlin) ;
Gámez, Irene (Hematology Department. Morales Meseguer University Hospital) ;
Campa, Daniele (Department of Biology. University of Pisa) ;
Moreno Aguado, Víctor (Facultat de Medicina. Universitat de Barcelona) ;
de Sanjosé, Silvia (Universitat de Barcelona) ;
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Álvarez, María Flor (Instituto de Investigación Biomédica de Salamanca) ;
Dierssen-Sotos, Trinidad (Universidad de Cantabria) ;
Jerez, Andrés (Vall d'Hebron Institut d'Oncologia) ;
Butrym, Aleksandra (Department of Cancer Prevention and Therapy. Medical University of Wrocław) ;
Norman, Aaron D. (Department of Quantitative Health Sciences. Mayo Clinic) ;
Luppi, Mario (University of Modena and Reggio Emilia) ;
Slager, Susan L. (Mayo Clinic) ;
Hemminki, Kari (Charles University in Prague) ;
Li, Yang (Hannover Medical School) ;
Berndt, Sonja I. (National Institutes of Health (Estats Units d'Amèrica)) ;
Casabonne, Delphine (Universitat de Barcelona) ;
Alcoceba, Miguel (Instituto de Investigación Biomédica de Salamanca) ;
Puiggros, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Netea, Mihai G. (Department for Immunology & Metabolism. University of Bonn) ;
Försti, Asta (Hopp Children's Cancer Center) ;
Canzian, Federico (German Cancer Research Center) ;
Sainz, Juan (Department of Biochemistry and Molecular Biology. Universidad de Granada)
Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. [...]
2023 - 10.3390/ijms24098005
International journal of molecular sciences, Vol. 24 Núm. 9 (may 2023) , p. 8005
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8.
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10 p, 4.1 MB |
2023 International African Swine Fever Workshop : Critical Issues That Need to Be Addressed for ASF Control
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Wang, Lihua (Kansas State University. Center on Vaccine Evaluation and Alternatives for Antimicrobials) ;
Ganges, Llilianne (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Dixon, Linda K. (The Pirbright Institute (Regne Unit)) ;
Bu, Zhigao (Chinese Academy of Agricultural Sciences) ;
Zhao, Dongming (Chinese Academy of Agricultural Sciences) ;
Truong, Quang Lam (Vietnam National University of Agriculture) ;
Richt, Juergen A. (Kansas State University) ;
Jin, Meilin (Huazhong Agricultural University) ;
Netherton, Christopher L. (The Pirbright Institute (Regne Unit)) ;
Benarafa, Charaf (University of Bern) ;
Summerfield, Artur (University of Bern) ;
Weng, Changjiang (Chinese Academy of Agricultural Sciences) ;
Peng, Guiqing (Huazhong Agricultural University) ;
Reis, Ana L. (The Pirbright Institute (Regne Unit)) ;
Han, Jun (China Agricultural University) ;
Penrith, Mary-Louise (University of Pretoria) ;
Mo, Yupeng (Dekang Agriculture and Animal Husbandry Group) ;
Su, Zhipeng (Liyuan Group) ;
Vu Hoang, Dang (National Institute of Veterinary Research) ;
Pogranichniy, Roman M. (Kansas State University) ;
Balaban-Oglan, David-Adrian (University of Agronomic Science and Veterinary Medicine of Bucharest) ;
Li, Yuzhen (Kansas State University) ;
Wang, Kewen (Zoetis China) ;
Cai, Xuepeng (Chinese Veterinary Drug Association) ;
Shi, Jishu (Kansas State University)
The 2023 International African Swine Fever Workshop (IASFW) took place in Beijing, China, on 18-20 September 2023. It was jointly organized by the U. S. -China Center for Animal Health (USCCAH) at Kansas State University (KSU) and the Chinese Veterinary Drug Association (CVDA) and sponsored by the United States Department of Agriculture Foreign Agricultural Service (USDA-FAS), Harbin Veterinary Research Institute, and Zoetis Inc. [...]
2023 - 10.3390/v16010004
Viruses, Vol. 16 (december 2023)
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9.
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50 p, 28.5 MB |
Pan-cancer proteogenomics connects oncogenic drivers to functional states
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Li, Yize (Washington University in St. Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tokheim, Collin (Harvard T.H. Chan School of Public Health) ;
Bailey, Matthew H. (Brigham Young University) ;
Yaron, Tomer (Weill Cornell Medicine) ;
Stathias, Vasileios (University of Miami Miller School of Medicine) ;
Geffen, Yifat (Massachusetts General Hospital) ;
Imbach, Kathleen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cao, Song (McDonnell Genome Institute) ;
Anand, Shankara (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Akiyama, Yo (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Liu, Wenke (NYU Grossman School of Medicine) ;
Wyczalkowski, Matthew A. (McDonnell Genome Institute) ;
Song, Yizhe (McDonnell Genome Institute) ;
Storrs, Erik P. (McDonnell Genome Institute) ;
Wendl, Michael C. (Washington University in St. Louis) ;
Zhang, Wubing (Dana-Farber Cancer Institute (Boston, Estats Units)) ;
Sibai, Mustafa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ruiz-Serra, Victoria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Liang, Wen-Wei (McDonnell Genome Institute) ;
Terekhanova, Nadezhda V. (McDonnell Genome Institute) ;
Martins Rodrigues, Fernanda (McDonnell Genome Institute) ;
Clauser, Karl R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Heiman, David I. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Zhang, Qing (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Aguet, Francois (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Calinawan, Anna Pamela (Icahn School of Medicine at Mount Sinai) ;
Dhanasekaran, Saravana Mohan (University of Michigan) ;
Birger, Chet (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Satpathy, Shankha (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Zhou, Daniel Cui (McDonnell Genome Institute) ;
Wang, Liang-Bo (McDonnell Genome Institute) ;
Baral, Jessika (McDonnell Genome Institute) ;
Johnson, Jared L. (Weill Cornell Medicine) ;
Huntsman, Emily M. (Weill Cornell Medicine) ;
Pugliese, Pietro (University of Sannio (Benevento, Itàlia)) ;
Colaprico, Antonio (University of Miami Miller School of Medicine) ;
Iavarone, Antonio (University of Miami Miller School of Medicine) ;
Chheda, Milan G. (Washington University in St. Louis) ;
Ricketts, Christopher J. (National Institutes of Health) ;
Fenyö, David (NYU Grossman School of Medicine) ;
Payne, Samuel H. (Brigham Young University) ;
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research) ;
Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ;
Gillette, Michael A. (Harvard Medical School) ;
Kumar-Sinha, Chandan (University of Michigan) ;
Lazar, Alexander (The University of Texas MD Anderson Cancer Center) ;
Cantley, Lewis (Weill Cornell Medicine) ;
Getz, Gad A. (Harvard Medical School) ;
Ding, Li (Siteman Cancer Center) ;
An, Eunkyung ;
Anurag, Meenakshi ;
Bavarva, Jasmin ;
Birrer, Michael J. ;
Ceccarelli, Michele ;
Chan, Daniel W. ;
Chinnaiyan, Arul M. ;
Cho, Hanbyul ;
Chowdhury, Shrabanti ;
Cieslik, Marcin P. ;
da Veiga Leprevost, Felipe ;
Day, Corbin ;
Domagalski, Marcin J. ;
Dou, Yongchao ;
Druker, Brian J. ;
Edwards, Nathan ;
Ellis, Matthew J. ;
Selvan, Myvizhi Esai ;
Foltz, Steven M. ;
Francis, Alicia ;
Gonzalez Robles, Tania J. ;
Gosline, Sara J. C. ;
Gümüş, Zeynep H. ;
Hiltke, Tara ;
Hong, Runyu ;
Hostetter, Galen ;
Hu, Yingwei ;
Huang, Chen ;
Huntsman, Emily ;
Jaehnig, Eric J. ;
Jewel, Scott D. ;
Ji, Jiayi ;
Jiang, Wen ;
Katsnelson, Lizabeth ;
Ketchum, Karen A. ;
Kolodziejczak, Iga ;
Lei, Jonathan T. ;
Liao, Yuxing ;
Lindgren, Caleb M. ;
Liu, Tao ;
Ma, Weiping ;
McKerrow, Wilson ;
Nesvizhskii, Alexey I. ;
Newton, Chelsea ;
Oldroyd, Robert ;
Omenn, Gilbert S. ;
Paulovich, Amanda G. ;
Petralia, Francesca ;
Reva, Boris ;
Rodland, Karin D. ;
Ruggles, Kelly V. ;
Rykunov, Dmitry ;
Savage, Sara R. ;
Schadt, Eric E. ;
Schnaubelt, Michael ;
Schraink, Tobias ;
Shi, Zhiao ;
Smith, Richard D. ;
Song, Xiaoyu ;
Tan, Jimin ;
Thangudu, Ratna R. ;
Tignor, Nicole ;
Wang, Joshua M. ;
Wang, Pei ;
Wang, Ying Cindy ;
Wen, Bo ;
Wiznerowicz, Maciej ;
Yi, Xinpei ;
Zhang, Bing ;
Zhang, Hui ;
Zhang, Xu ;
Zhang, Zhen ;
Universitat Autònoma de Barcelona
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-cancer analysis uncovers insights into the impacts of cancer drivers by identifying their significant cis-effects and distal trans-effects quantified at the RNA, protein, and phosphoprotein levels. [...]
2023 - 10.1016/j.cell.2023.07.014
Cell, Vol. 186 Núm. 18 (31 2023) , p. 3921-3944.e25
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10.
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27 p, 8.1 MB |
Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
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Liang, Wen-Wei (Washington University in St. Louis) ;
Lu, Rita Jui-Hsien Lu (Washington University in St. Louis) ;
Jayasinghe, Reyka G. (Washington University in St. Louis) ;
Foltz, Steven M. (Washington University in St. Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Geffen, Yifat (Massachusetts General Hospital) ;
Wendl, Michael C. (Department of Mathematics. Washington University in St. Louis) ;
Lazcano, Rossana (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ;
Kolodziejczak, Iga (Medical University of Warsaw) ;
Song, Yizhe (Washington University in St. Louis) ;
Govindan, Akshay (Washington University in St. Louis) ;
Demicco, Elisabeth G. (University of Toronto) ;
Li, Xiang (Washington University in St. Louis) ;
Li, Yize (Washington University in St. Louis) ;
Sethuraman, Sunantha (Washington University in St. Louis) ;
Payne, Samuel H. (Department of Biology. Brigham Young University) ;
Fenyö, David (Department of Biochemistry and Molecular Pharmacology. NYU Grossman School of Medicine) ;
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research. National Cancer Institute) ;
Wiznerowicz, Maciej (Poznań University of Medical Sciences) ;
Shen, Hui (Van Andel Research Institute) ;
Mani, D.R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Rodland, Karin D. (Developmental. and Cancer Biology. Oregon Health & Science University) ;
Lazar, Alexander J. (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ;
Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ;
Ding, Li (Washington University in St. Louis) ;
Universitat Autònoma de Barcelona
DNA methylation plays a critical role in establishing and maintaining cellular identity. However, it is frequently dysregulated during tumor development and is closely intertwined with other genetic alterations. [...]
2023 - 10.1016/j.ccell.2023.07.013
Cancer Cell, Vol. 41 Núm. 9 (november 2023) , p. 1567-1585.e7
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