Personalised, image-guided, noninvasive brain stimulation in gliomas : Rationale, challenges and opportunities
Sprugnoli, Giulia (Harvard Medical School. Berenson-Allen Center for Noninvasive Brain Stimulation)
Rossi, Simone (University of Siena. Department of Medicine, Surgery and Neuroscience, Neurology and Clinical Neurophysiology Unit)
Rotenberg, Alexander (Harvard Medical School. Department of Neurology and Division of Epilepsy and Clinical Neurophysiology)
Pascual Leone, Álvaro (Institut Germans Trias i Pujol. Institut Guttmann)
El-Fakhri, Georges (Harvard Medical School, Boston. Department of Radiology)
Golby, Alexandra J. (Harvard Medical School. Department of Neurosurgery and Radiology)
Santarnecchi, Emiliano (Harvard Medical School. Berenson-Allen Center for Noninvasive Brain Stimulation)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Malignant brain tumours are among the most aggressive human cancers, and despite intensive efforts made over the last decades, patients' survival has scarcely improved. Recently, high-grade gliomas (HGG) have been found to be electrically integrated with healthy brain tissue, a communication that facilitates tumour mitosis and invasion. This link to neuronal activity has provided new insights into HGG pathophysiology and opened prospects for therapeutic interventions based on electrical modulation of neural and synaptic activity in the proximity of tumour cells, which could potentially slow tumour growth. Noninvasive brain stimulation (NiBS), a group of techniques used in research and clinical settings to safely modulate brain activity and plasticity via electromagnetic or electrical stimulation, represents an appealing class of interventions to characterise and target the electrical properties of tumour-neuron interactions. Beyond neuronal activity, NiBS may also modulate function of a range of substrates and dynamics that locally interacts with HGG (e. g. , vascular architecture, perfusion and blood-brain barrier permeability). Here we discuss emerging applications of NiBS in patients with brain tumours, covering potential mechanisms of action at both cellular, regional, network and whole-brain levels, also offering a conceptual roadmap for future research to prolong survival or promote wellbeing via personalised NiBS interventions.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	Brain tumours ; Glioma ; HGG ; NiBS ; Noninvasive brain stimulation ; Neuromodulation
Publicat a:	EBioMedicine, Vol. 70 (august 2021) , ISSN 2352-3964

DOI: 10.1016/j.ebiom.2021.103514
PMID: 34391090

12 p, 2.0 MB

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