Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress
Hakimizadeh, Elham (Rafsanjan University of Medical Sciences. Physiology-Pharmacology Research Center)
Zamanian, Mohammad (Hamadan University of Medical Sciences. School of Nahavand Paramedical)
Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
Sciorati, Clara (IRCCS Ospedale San Raffaele Scientific Institute. Division of Immunology, Transplantation and Infectious Diseases)
Nikbakhtzadeh, Marjan (University of Medical Sciences. Department of Physiology)
Kujawska, Małgorzata (Poznan University of Medical Sciences. Department of Toxicology)
Kaeidi, Ayat (Rafsanjan University of Medical Sciences. Physiology-Pharmacology Research Center)
Hassanshahi, Jalal (Rafsanjan University of Medical Sciences. Physiology-Pharmacology Research Center)
Fatemi, Iman (Kerman University of Medical Sciences. Research Center of Tropical and Infectious Diseases)
Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal

Data:	2021
Resum:	The long-term treatment of mice with D-galactose (D-gal) induces the overproduction of reactive oxygen species (ROS) and is a well-accepted experimental model of oxidative stress-linked cognitive disorders in physiological aging. Calcium dobesilate (CaD, Doxium®) is an established vasoactive and angioprotective drug commonly used for the clinical treatment of diabetic retinopathy and chronic venous insufficiency. It has antioxidant properties and controls vascular permeability. In the current study, we evaluated the protective effects of CaD (50 and 100 mg/kg/day p. o. ) in male mice treated with D-gal (500 mg/kg/day p. o. ) for six weeks. Results demonstrated that body weight loss, anxiety-like and cognitive impairments of D-gal-treated animals were reversed by CaD administration as evaluated by the measurement of mice performance in elevated plus-maze, Y-maze, and shuttle box tests. CaD treatment also inhibited the oxidative stress in aging mouse brains by decreasing malondialdehyde (MDA) levels and increasing superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) enzyme activities. These results could open new perspectives for the clinical use of CaD in treating and preventing cognitive impairment in older people.
Nota:	Funding: This work was supported by grant no. 97175 from the Vice-Chancellor for Research and Technology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. It also received support from Memorial Mercè Llort Sender 2021/80/092421.1.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Aging ; Antioxidant activity ; Calcium dobesilate ; Doxium ; D-galactose ; Mice ; Oxidative stress
Publicat a:	Antioxidants, Vol. 10 Núm. 5 (2021) , p. 649, ISSN 2076-3921

DOI: 10.3390/antiox10050649
PMID: 33922431

11 p, 1.6 MB

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