Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery : results of a pragmatic cohort study in Catalonia
Badia, Josep M. (Hospital General de Granollers)
Flores-Yelamos, Miriam (Hospital General de Granollers)
Vázquez Fariñas, Ana (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Arroyo-Garcia, Nares (Hospital General de Granollers)
Puig-Asensio, Mireia (Hospital Universitari de Bellvitge)
Parés, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pera, Miguel (Hospital del Mar (Barcelona, Catalunya))
López-Contreras, Joaquín (Institut d'Investigació Biomèdica Sant Pau)
Limón, Enric (Universitat de Barcelona)
Pujol, Miquel (Hospital Universitari de Bellvitge)

Date:	2021
Abstract:	Background: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The aim of this study was to analyze the effect of a bundle including both measures in a National Infection Surveillance Network in Catalonia. Methods: Pragmatic cohort study to assess the effect of OAP and MBP in reducing SSI rate in 65 hospitals, comparing baseline phase (BP: 2007-2015) with implementation phase (IP: 2016-2019). To compare the results, a logistic regression model was established. Results: Out of 34,421 colorectal operations, 5180 had SSIs (15. 05%). Overall SSI rate decreased from 18. 81% to 11. 10% in BP and IP, respectively (OR 0. 539, CI95 0. 507-0. 573, p < 0. 0001). Information about bundle implementation was complete in 61. 7% of cases. In a univariate analysis, OAP and MBP were independent factors in decreasing overall SSI, with OR 0. 555, CI95 0. 483-0. 638, and OR 0. 686, CI95 0. 589-0. 798, respectively; and similarly, organ/space SSI (O/S-SSI) (OR 0. 592, CI95 0. 494-0. 710, and OR 0. 771, CI95 0. 630-0. 944, respectively). However, only OAP retained its protective effect at both levels at multivariate analyses. Conclusions: oral antibiotic prophylaxis decreased the rates of SSI and O/S-SSI in a large series of elective colorectal surgery.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Estudi clínic ; recerca ; Versió publicada
Subject:	Colorectal surgery ; Surgical site infection ; Surgical wound infection ; Oral antibiotic prophylaxis ; Mechanical bowel preparation ; Preventative measures
Published in:	Journal of clinical medicine, Vol. 10 Núm. 23 (november 2021) , p. 5636, ISSN 2077-0383

DOI: 10.3390/jcm10235636
PMID: 34884337

10 p, 444.4 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles