Oxidative Stress in Structural Valve Deterioration : A Longitudinal Clinical Study
Galiñanes, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Casós, Kelly (Hospital Universitari de Bellvitge)
Blasco-Lucas, Arnau (Hospital Universitari de Bellvitge)
Permanyer, Eduard (Centro Médico Teknon)
Máñez, Rafael (Hospital Universitari de Bellvitge)
Le Tourneau, Thierry (Université de Nantes)
Barquinero, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Bottio, Tomaso (University Hospital of Padova (Pàdua, Itàlia))
Roussel, Jean Christian (CHU de Nantes)
Fellah-Hebia, Imen (CHU de Nantes)
Sénage, Thomas (Université de Nantes)
Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Badano, Luigi P. (San Luca Hospital(Itàlia))
Ruiz-Majoral, Alejandro (Hospital Universitari de Bellvitge)
Galli, Cesare (Avantea and Fondazione Avantea Onlus (Itàlia))
Padler-Karavani, Vered (Tel Aviv University)
Soulillou, Jean-Paul (Centre Hospitalier Universitaire de Nantes)
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron)
Cozzi, Emanuele (University Hospital of Padova (Pàdua, Itàlia))
Costa, Cristina (Hospital Universitari de Bellvitge)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	The cause of structural valve deterioration (SVD) is unclear. Therefore, we investigated oxidative stress markers in sera from patients with bioprosthetic heart valves (BHVs) and their association with SVD. Blood samples were taken from SVD (Phase A) and BHV patients during the first 24 (Phase B1) and >48 months (Phase B2) after BHV implantation to assess total antioxidant capacity (TAC), malondialdehyde (MDA), and nitrotyrosine (NT). The results show that MDA levels increased significantly 1 month after surgery in all groups but were higher at 6 months only in incipient SVD patients. NT levels increased gradually for the first 24 months after implantation in the BHV group. Patients with transcatheter aortic valve implantation (TAVI) showed even higher levels of stress markers. After >48 months, MDA and NT continued to increase in BHV patients with a further elevation after 60-72 months; however, these levels were significantly lower in the incipient and established SVD groups. In conclusion, oxidative stress may play a significant role in SVD, increasing early after BHV implantation, especially in TAVI cases, and also after 48 months' follow-up, but decreasing when SVD develops. Oxidative stress potentially represents a target of therapeutic intervention and a biomarker of BHV dysfunction.
Ajuts:	European Commission 603049 Ministerio de Economía y Competitividad PI15/00181
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Oxidative stress ; Aortic valve ; Biological heart valves ; Transcatheter aortic valve implantation ; Structural valve deterioration ; Protein nitration ; Lipid peroxidation
Publicat a:	Biomolecules, Vol. 12 (october 2022) , ISSN 2218-273X

DOI: 10.3390/biom12111606
PMID: 36358956

21 p, 5.9 MB

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