Characteristics and Management of Patients with Refractory or Unexplained Chronic Cough in Outpatient Hospital Clinics in Spain : A Retrospective Multicenter Study
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Dávila, Ignacio (Universidad de Salamanca)
Puente, Luis (Hospital General Universitario Gregorio Marañón)
Quirce Gancedo, Santiago (Hospital Universitario La Paz (Madrid))
Arismendi, Ebymar (Hospital Clínic i Provincial de Barcelona)
Díaz Palacios, Miguel (Hospital Universitari i Politècnic La Fe (València))
Pereira-Vega, Antonio (Hospital Juan Ramón Jiménez (Huelva))
De Diego, Alfredo (Hospital Universitari i Politècnic La Fe (València))
Rodriguez Hermosa, Juan Luis (Universidad Complutense de Madrid)
Cea-Calvo, Luis (MSD España)
Sánchez Jareño, Marta (MSD España)
López Cotarelo, Pilar (MSD España)
Universitat Autònoma de Barcelona

Publicació:	Springer New York, 2023
Resum:	Purpose: Chronic cough (cough that persists for ≥ 8 weeks) can cause a range of physical symptoms and psychosocial effects that significantly impair patients' quality of life. Refractory chronic cough (RCC) and unexplained chronic cough (UCC) are challenging to diagnose and manage, with substantial economic implications for healthcare systems. Methods: This retrospective multicenter non-interventional study aimed to characterize the profile and health resource consumption of patients with RCC or UCC who attended outpatient clinics at Spanish hospitals. Data were collected from medical records of patients with RCC or UCC for up to 3 years before study inclusion. Results: The patient cohort (n = 196) was representative of the chronic cough population (77. 6% female, mean age 58. 5 years). Two-thirds of patients (n = 126) had RCC. The most frequently visited doctors were pulmonologists (93. 4% of patients) and primary care physicians (78. 6%), with a mean of 5 visits per patient over three years' observation. The most common diagnostic tests were chest x-ray (83. 7%) and spirometry with bronchodilation (77. 0%). The most commonly prescribed treatments were proton pump inhibitors (79. 6%) and respiratory medications (87. 8%). Antibiotics were prescribed empirically to 56 (28. 6%) patients. Differences between RCC or UCC groups related mainly to approaches used to manage cough-associated conditions (gastroesophageal reflux disease, asthma) in patients with RCC. Conclusion: RCC and UCC are responsible for high health resource utilization in Spanish hospitals. Specific treatments targeting the pathological processes driving chronic cough may provide opportunities to reduce the associated burden for patients and healthcare systems.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Health resource utilization ; Noninterventional study ; Refractory chronic cough ; Spain ; Unexplained chronic cough
Publicat a:	Lung, ISSN 1432-1750

DOI: 10.1007/s00408-023-00620-y
PMID: 37160771

12 p, 608.0 KB

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