The novel inflammatory biomarker GlycA and triglyceride-rich lipoproteins are associated with the presence of subclinical myocardial dysfunction in subjects with type 1 diabetes mellitus
Puig-Jové, Carlos (Universitat Autònoma de Barcelona. Departament de Medicina)
Julve i Gil, Josep (Institut d'Investigació Biomèdica Sant Pau)
Castelblanco, Esmeralda (Washington University School of Medicine)
Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Amigó, Núria (Universitat Rovira i Virgili)
Andersen, Henrik U. (Steno Diabetes Center Copenhagen)
Ahluwalia, Tarunveer Singh (University of Copenhagen)
Rossing, Peter (University of Copenhagen)
Mauricio, Didac (Institut d'Investigació Biomèdica Sant Pau)
Jensen, Magnus T. (Copenhagen University Hospital Amager Hvidovre)
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Date:	2022
Abstract:	Subjects with Type 1 diabetes mellitus (T1DM) have an increased incidence of heart failure (HF). Several pathophysiological mechanisms have been involved in its development. The aim of this study was to analyze the potential contribution of the advanced lipoprotein profile and plasma glycosylation (GlycA) to the presence of subclinical myocardial dysfunction in subjects with T1DM. We included subjects from a Danish cohort of T1DM subjects (Thousand & 1 study) with either diastolic and/or systolic subclinical myocardial dysfunction, and a control group without myocardial dysfunction, matched by age, sex and HbA1c. All underwent a transthoracic echocardiogram and an advanced lipoprotein profile obtained by using the NMR-based Liposcale® test. GlycA NMR signal was also analyzed. Systolic dysfunction was defined as left ventricular ejection fraction ≤ 45% and diastolic dysfunction was considered as E/e'≥12 or E/e' 8-12 + volume of the left atrium.
Grants:	Instituto de Salud Carlos III PI17/00232 Instituto de Salud Carlos III PI17/01362 Ministerio de Economía y Competitividad CB15/00071
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	GlycA ; Heart failure ; Lipoproteins ; Myocardial dysfunction ; Type 1 diabetes
Published in:	Cardiovascular diabetology, Vol. 21 (november 2022) , ISSN 1475-2840

DOI: 10.1186/s12933-022-01652-z
PMID: 36434633

11 p, 1.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles