Barriers to genetic testing in clinical psychiatry and ways to overcome them : from clinicians' attitudes to sociocultural differences between patients across the globe
Pinzón-Espinosa, Justo (Institut d'Investigació Biomèdica Sant Pau)
van der Horst, Marte (Outpatient Second Opinion Clinic. GGNet Mental Health)
Zinkstok, Janneke (Karakter Child and Adolescent Psychiatry)
Austin, Jehannine (Department of Psychiatry and Medical Genetics. Genetic Counselling Training Program. University of British Columbia)
Aalfs, Cora M. (University Medical Center Utrecht)
Batalla, Albert (University Medical Center Utrecht)
Sullivan, Patrick (Karolinska Institutet (Estocolm, Suècia))
Vorstman, Jacob (Department of Psychiatry. University of Toronto)
Luykx, Jurjen J. (Outpatient Second Opinion Clinic. GGNet Mental Health)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Genetic testing has evolved rapidly over recent years and new developments have the potential to provide insights that could improve the ability to diagnose, treat, and prevent diseases. Information obtained through genetic testing has proven useful in other specialties, such as cardiology and oncology. Nonetheless, a range of barriers impedes techniques, such as whole-exome or whole-genome sequencing, pharmacogenomics, and polygenic risk scoring, from being implemented in psychiatric practice. These barriers may be procedural (e. g. , limitations in extrapolating results to the individual level), economic (e. g. , perceived relatively elevated costs precluding insurance coverage), or related to clinicians' knowledge, attitudes, and practices (e. g. , perceived unfavorable cost-effectiveness, insufficient understanding of probability statistics, and concerns regarding genetic counseling). Additionally, several ethical concerns may arise (e. g. , increased stigma and discrimination through exclusion from health insurance). Here, we provide an overview of potential barriers for the implementation of genetic testing in psychiatry, as well as an in-depth discussion of strategies to address these challenges.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Matèria:	Genetic Testing ; Health Knowledge, Attitudes, Practice ; Humans ; Multifactorial Inheritance ; Psychiatry
Publicat a:	Translational psychiatry, Vol. 12 Núm. 1 (december 2022) , p. 442, ISSN 2158-3188

DOI: 10.1038/s41398-022-02203-6
PMID: 36220808

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