Transmission of HIV drug resistance and the predicted effect on current first-line regimens in Europe
Hofstra, Laura Marije (University Medical Center Utrecht (Països Baixos))
Sauvageot, Nicolas (Luxembourg Institute of Health (Luxemburg))
Albert, Jan (Karolinska Institute (Solna, Suècia))
Alexiev, Ivailo (National Center of Infectious and Parasitic Diseases (Sofia, Bulgària))
Garcia, Federico (Instituto de Investigación Biosanitaria (Granada, Andalusia))
Struck, Daniel (Luxembourg Institute of Health (Luxemburg))
van de Vijver, David (Erasmus MC. University Medical Center (Rotterdam, Països Baixos))
Åsjö, Birgitta (University of Bergen (Noruega))
Beshkov, Danail (National Center of Infectious and Parasitic Diseases (Sofia, Bulgària))
Coughlan, Suzie (University College Dublin (Irlanda))
Descamps, Diane (Université Paris Diderot Sorbonne Paris Cité (París, França))
Griskevicius, Algirdas (Lithuanian AIDS Center (Vílnius, lituània))
Hamouda, Osamah (Robert Koch Institute (Berlín, Alemanya))
Horban, Andrzej (Hospital of Infectious Diseases (Varsòvia, Polònia))
Van Kasteren, Marjo (St. Elisabeth Hospital (Tilburg, Països Baixos))
Kolupajeva, Tatjana (Infectiology Center of Latvia (Riga, Letònia))
Kostrikis, Leondios (University of Cyprus (Nicòsia, Xipre))
Liitsola, Kirsi (National Institute for Health and Welfare (Helsink, Finlàndia))
Linka, Marek (National Reference Laboratory for HIV/AIDS. National Institute of Public Health (Praga, República Txeca))
Mor, Orna (National HIV Reference Laboratory. Chaim Sheba Medical Center (Tel-Hashomer, Israel))
Nielsen, Claus (Statens Serum Institut (Copenhagen, Dinamarca))
Otelea, Dan (National Institute for Infectious Diseases (Bucarest, Romania))
Paraskevis, Dimitrios (University of Athens (Atenes, Grècia))
Paredes, Roger (Fundació IrsiCaixa (Badalona, Catalunya))
Poljak, Mario (University of Ljubljana (Eslovènia))
Puchhammer-Stöckl, Elisabeth (Medical University Vienna (Viena, Àustria))
Sönnerborg, Anders (Karolinska Institute (Solna, Suècia))
Stanekova, D. (Slovak Medical University (Bratislava, Eslovàquia))
Stanojevic, Maja (University of Belgrade (Belgrad, Sèrbia))
Van Laethem, Kristel (Rega Institute for Medical Research (Lovaina, Bèlgica))
Zazzi, Maurizio (University of Siena (Itàlia))
Lepej, Snjezana Zidovec (University Hospital for Infectious Diseases (Zagred, Croàcia))
Boucher, Charles A. B. (Erasmus MC. University Medical Center (Rotterdam, Països Baixos))
Schmit, Jean Claude (Luxembourg Institute of Health (Luxemburg))
Wensing, Annemarie Marie J. (University Medical Center Utrecht (Països Baixos))
Sarcletti, M.
Schmied, B.
Geit, M.
Balluch, G.
Vandamme, A. M. (Katholieke Universiteit Leuven (Lovaina, Bèlgica))
Vercauteren, Jurgen (Katholieke Universiteit Leuven (Lovaina, Bèlgica))
Derdelinckx, Inge (Katholieke Universiteit Leuven (Lovaina, Bèlgica))
Sasse, André (Katholieke Universiteit Leuven (Lovaina, Bèlgica))
Bogaert, M.
Ceunen, H.
De Roo, A.
De Wit, S.
Echahidi, F.
Fransen, K.
Goffard, J.C.
Goubau, P.
Goudeseune, E.
Yombi, J.C.
Lacor, P.
Liesnard, C.
Moutschen, M.
Pierard, D.
Rens, R.
Schrooten, Y.
Vaira, D.
Vandekerckhove, Linos
Van Den Heuvel, A.
Van Der Gucht, B.
Van Ranst, M.
Van Wijngaerden, E.
Vandercam, B.
Vekemans, M.
Verhofstede, C.
Clumeck, N.
Begovac, J.
Demetriades, I.
Kousiappa, I.
Demetriou, V.
Hezka, J.
Maly, M.
Machala, L.
Jørgensen, L.B.
Gerstoft, J.
Mathiesen, L.
Pedersen, C.
Nielsen, H.
Laursen, A.
Kvinesdal, B.
Ristola, M.
Suni, J.
Sutinen, J.
Assoumou, Lambert
Castor, G.
Grude, M.
Flandre, P.
Storto, A.
Kücherer, C.
Berg, T.
Braun, P.
Poggensee, G.
Däumer, M.
Eberle, J.
Heiken, H.
Kaiser, R.
Knechten, H.
Korn, K.
Müller, H.
Neifer, S.
Schmidt, B.
Walter, H.
Gunsenheimer-Bartmeyer, B.
Harrer, T.
Hatzakis, A.
Zavitsanou, A.
Vassilakis, A.
Lazanas, M.
Chini, M.
Lioni, A.
Sakka, V.
Kourkounti, S.
Paparizos, V.
Antoniadou, A.
Papadopoulos, A.
Poulakou, G.
Katsarolis, I.
Protopapas, K.
Chryssos, G.
Drimis, S.
Gargalianos, P.
Xylomenos, G.
Lourida, G.
Psichogiou, M.
Daikos, G.L.
Sipsas, N.V.
Kontos, A.
Gamaletsou, M.N.
Koratzanis, G.
Sambatakou, E.
Mariolis, H.
Skoutelis, A.
Papastamopoulos, V.
Georgiou, O.
Panagopoulos, P.
Maltezos, E.
De Gascun, C.
Byrne, C.
Duffy, M.
Bergin, C.
Reidy, D.
Farrell, G.
Lambert, Jo
O'Connor, E.
Rochford, A.
Low, J.
Coakely, P.
O'Dea, S.
Hall, W.
Levi, I.
Chemtob, D.
Grossman, Z.
De Luca, A.
Balotta, C.
Riva, C.
Mussini, C.
Caramma, I.
Capetti, A.
Colombo, M.C.
Rossi, C.
Prati, F.
Tramuto, F.
Vitale, F.
Ciccozzi, M.
Angarano, G.
Rezza, G.
Vasins, O.
Lipnickiene, V.
Hemmer, R.
Arendt, V.
Michaux, C.
Staub, T.
Sequin-Devaux, C.
Van Kessel, A.
Van Bentum, P.H.M.
Brinkman, K.
Connell, B.J.
Van Der Ende, M.E.
Hoepelman, I.M.
Kuipers, M.
Langebeek, N.
Richter, C.
Santegoets, R.M.W.J.
Schrijnders-Gudde, L.
Schuurman, R.
Van De Ven, B.J.M.
Kran, A.M.B.
Ormaasen, V.
Aavitsland, P.
Stanczak, J.J.
Stanczak, G.P.
Firlag-Burkacka, E.
Wiercinska-Drapalo, A.
Jablonowska, Elżbieta
Maolepsza, E.
Leszczyszyn-Pynka, M.
Szata, W.
Camacho, R.
Palma, C.
Borges, F.
Paixão, T.
Duque, V.
Araújo, F.
Paraschiv, S.
Tudor, A.M.
Cernat, R.
Chiriac, C.
Dumitrescu, F.
Prisecariu, L.J.
Jevtovic, D.
Salemovic, D.
Stanekova, D.
Habekova, M.
Chabadová, Z.
Drobkova, T.
Bukovinova, P.
Shunnar, A.
Truska, P.
Lunar, M.
Babic, D.
Tomazic, J.
Vidmar, L.
Vovko, T.
Karner, P.
Monge, S.
Moreno, S.
Del Amo, J.
Asensi, V.
Sirvent, J.L.
De Mendoza, C.
Delgado, Raquel (Institut d'Investigació Biomèdica Sant Pau)
Gutiérrez, F.
Berenguer, J.
Garcia-Bujalance, S.
Stella, N.
De Los Santos, I.
Blanco, J.R.
Dalmau, D.
Rivero, M.
Segura, F.
Elías, María Jesús Pérez
Álvarez, Mar
Chueca, N.
Rodríguez-Martín, C.
Vidal, C.
Palomares, J.C.
Viciana, I.
Viciana, P.
Cordoba, J.
Aguilera, A.
Domingo, Pere (Institut d'Investigació Biomèdica Sant Pau)
Galindo, María José
Miralles, C.
Del Pozo, M.A.
Ribera, E.
Iribarren, J.A.
Ruiz, L.
De La Torre, J.
Vidal, F.
Clotet Sala, Bonaventura
Heidarian, A.
Aperia-Peipke, K.
Axelsson, M.
Mild, M.
Karlsson, A.
Thalme, A.
Naver, Lars
Bratt, G.
Blaxhult, A.
Gisslén, M.
Svennerholm, B.
Björkman, P.
Säll, C.
Mellgren, None
Lindholm, A.
Kuylenstierna, N.
Montelius, R.
Azimi, F.
Johansson, B.
Carlsson, M.
Johansson, E.
Ljungberg, B.
Ekvall, H.
Strand, A.
Mäkitalo, S.
Öberg, S.
Holmblad, P.
Höfer, M.
Holmberg, H.
Josefson, P.
Ryding, U.
Bergbrant, I.
Universitat Autònoma de Barcelona

Date:	2016
Abstract:	Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. In addition to optimizing individual patient management, these baseline resistance data enable transmitted drug resistance (TDR) to be surveyed for public health purposes. The SPREAD program systematically collects data to gain insight into TDR occurring in Europe since 2001. Demographic, clinical, and virological data from 4140 antiretroviral-naive human immunodeficiency virus (HIV)-infected individuals from 26 countries who were newly diagnosed between 2008 and 2010 were analyzed. Evidence of TDR was defined using the WHO list for surveillance of drug resistance mutations. Prevalence of TDR was assessed over time by comparing the results to SPREAD data from 2002 to 2007. Baseline susceptibility to antiretroviral drugs was predicted using the Stanford HIVdb program version 7. 0. The overall prevalence of TDR did not change significantly over time and was 8. 3% (95% confidence interval, 7. 2%-9. 5%) in 2008-2010. The most frequent indicators of TDR were nucleoside reverse transcriptase inhibitor (NRTI) mutations (4. 5%), followed by nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations (2. 9%) and protease inhibitor mutations (2. 0%). Baseline mutations were most predictive of reduced susceptibility to initial NNRTI-based regimens: 4. 5% and 6. 5% of patient isolates were predicted to have resistance to regimens containing efavirenz or rilpivirine, respectively, independent of current NRTI backbones. Although TDR was highest for NRTIs, the impact of baseline drug resistance patterns on susceptibility was largest for NNRTIs. The prevalence of TDR assessed by epidemiological surveys does not clearly indicate to what degree susceptibility to different drug classes is affected.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Antiretroviral therapy ; Drug resistance ; Europe ; HIV-1 ; Transmission
Published in:	Clinical Infectious Diseases, Vol. 62 Núm. 5 (january 2016) , p. 655-663, ISSN 1537-6591

DOI: 10.1093/cid/civ963
PMID: 26620652

9 p, 419.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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