Post COVID-19 Condition in Children and Adolescents : An Emerging Problem
Izquierdo-Pujol, Jon (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Moron-Lopez, Sara (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Dalmau, Judith (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Gonzalez-Aumatell, Alba (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Carreras-Abad, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Méndez Hernández, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rodrigo Gonzalo de Líria, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became a pandemic in 2020 and by March 2022 had caused more than 479 million infections and 6 million deaths worldwide. Several acute and long-term symptoms have been reported in infected adults, but it remains unclear whether children/adolescents also experience persistent sequelae. Hence, we conducted a review of symptoms and pathophysiology associated with post-coronavirus disease 2019 (post-COVID-19) condition in children and adolescents. We reviewed the scientific literature for reports on persistent COVID-19 symptoms after SARS-CoV-2 infection in both children/adolescents and adults from 1 January 2020 to 31 March 2022 (based on their originality and relevance to the broad scope of this review, 26 reports were included, 8 focused on adults and 18 on children/adolescents). Persistent sequelae of COVID-19 are less common in children/adolescents than in adults, possibly owing to a lower frequency of SARS-CoV-2 infection and to the lower impact of the infection itself in this age group. However, cumulative evidence has shown prolonged COVID-19 to be a clinical entity, with few pathophysiological associations at present. The most common post-COVID-19 symptoms in children/adolescents are fatigue, lack of concentration, and muscle pain. In addition, we found evidence of pathophysiology associated with fatigue and/or headache, persistent loss of smell and cough, and neurological and/or cardiovascular symptoms. This review highlights the importance of unraveling why SARS-CoV-2 infection may cause post-COVID-19 condition and how persistent symptoms might affect the physical, social, and psychological well-being of young people in the future.
Ajuts:	Agencia Estatal de Investigación PID2019-109870RB-I00
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adolescents ; Children ; COVID-19 ; Long-covid-19 ; Long-haul COVID ; Post COVID-19 condition ; Post-acute COVID-19 syndrome
Publicat a:	Frontiers in Pediatrics, Vol. 10 (may 2022) , ISSN 2296-2360

DOI: 10.3389/fped.2022.894204
PMID: 35633949

9 p, 1.1 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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