Unraveling athletic performance : Transcriptomics and external load monitoring in handball competition
Ezquerra Condeminas, Pol (Universitat Politècnica de Catalunya)
Mallol, Milos (Barça Innvotation HUB)
Font, Roger (National Institut of Physical Education of Catalonia)
Tremps, Victor (Universitat Ramon Llull. Blanquerna)
Gutiérrez, Jose Antonio (Fútbol Club Barcelona. Serveis Mèdics)
Rodas Font, Gil (Fútbol Club Barcelona. Serveis Mèdics)
Perera Lluna, Alexandre (Institut de Recerca Sant Joan de Déu)
Soria Fernández, José Manuel (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Objective This study aims to comprehend the impact of handball practice on sub-elite athletes by investigating transcriptomic changes that occur during a match. The primary focus encompasses a dual objective: firstly, to identify and characterize these transcriptomic alterations, and secondly, to establish correlations between internal factors (gene expression), and external loads measured through Electronic Performance and Tracking Systems (EPTS variables). Ultimately, this comprehensive analysis seeks to evaluate both acute and chronic responses to exercise within the context of handball training. Methods The study included sixteen elite male athletes from the FC Barcelona handball second team. Blood samples were extracted at three different time points: before the match at baseline levels (T1), immediately upon completion (T2), and 24 hours after completion (T3). Differential gene expression, Gene Ontology Term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were conducted in two comparisons: Comparison 1 (T1 vs T2) and Comparison 2 (T1 vs T3). Further, the correlation between gene expression levels and training variables (external load) was conducted. Results In T1 vs T2, 3717 of the 14632 genes detected were differentially expressed (adjusted pvalue < 0. 05), and enrichment of terms related to the immune system, mitochondria, and metabolic processes was found. Further, significant linear correlations were obtained between High-Speed running (HSR) and high-intensity variables such as acceleration ACC and deceleration DEC values with amino acids, and inflammatory and oxidative environment- related pathways, both in chronic and acute response. Conclusions This research highlights the effects of external workload on elite athletes during a handball match and throughout the season. The study identifies deregulation in the immune system, mitochondrial functions, and various metabolic pathways during the match. Additionally, it establishes correlations between the external load and pathways associated with amino acids, inflammation, oxidative environment, and regulation. These findings offer insights into the immediate and chronic responses of athletes to physical effort.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Amino Acids ; Athletes ; Athletic Performance ; Gene Expression Profiling ; Humans ; Male ; Running
Publicat a:	PloS one, Vol. 19 Núm. 3 March (march 2024) , p. e0299556, ISSN 1932-6203

DOI: 10.1371/journal.pone.0299556
PMID: 38466679

20 p, 2.6 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats