Impact of repetitive negative thinking on subjective cognitive decline : insights into cognition and brain structure
Mulet-Pons, Lídia (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Solé-Padullés, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Cabello-Toscano, María (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Abellaneda Pérez, Kilian (Institut Germans Trias i Pujol)
Perellón-Alfonso, Ruben (Institut Germans Trias i Pujol)
Cattaneo, Gabriele (Institut Germans Trias i Pujol)
Solana-Sánchez, Javier (Institut Germans Trias i Pujol)
Alviarez-Schulze, Vanessa (Institut Germans Trias i Pujol)
Bargalló, Núria (Hospital Clínic i Provincial de Barcelona)
Tormos, Jose M. (Universidad Católica de Valencia)
Pascual Leone, Álvaro (Harvard Medical School)
Bartrés-Faz, David (Institut Germans Trias i Pujol. Institut Guttmann)
Vaqué-Alcázar, Lídia (Institut de Recerca Sant Pau)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Introduction: Individuals with subjective cognitive decline (SCD) express concern about self-perceived cognitive decline despite no objective impairment and are at higher risk of developing Alzheimer's disease. Despite documented links between SCD and repetitive negative thinking (RNT), the specific impact of RNT on brain integrity and cognition in exacerbating the SCD condition remains unclear. We aimed to investigate the influence of RNT on global cognition and brain integrity, and their interrelationships among healthy middle-aged and older adults experiencing SCD. Methods: Out of 616 individuals with neuroimaging and neuropsychological data available, 89 (mean age = 56. 18 years; 68. 54% females) met SCD criteria. Eighty-nine non-SCD individuals matched by age, sex, and education were also selected and represented the control group (mean age = 56. 09 years; 68. 54% females). Global cognition was measured using the preclinical Alzheimer's cognitive composite (PACC5), which includes dementia screening, episodic memory, processing speed, and category fluency tests. RNT was calculated through three questionnaires assessing intrusive thoughts, persistent worry, and rumination. We generated cortical thickness (CTh) maps and quantified the volume of white matter lesions (WML) in the whole brain, as grey and white matter integrity measures, respectively. Results: SCD individuals exhibited higher RNT scores, and thinner right temporal cortex compared to controls. No differences were observed in PACC5 and WML burden between groups. Only the SCD group demonstrated positive associations in the CTh-PACC5, CTh-RNT, and WML-RNT relationships. Discussion: In this cross-sectional study, RNT was exclusively associated with brain integrity in SCD. Even though our findings align with the broader importance of investigating treatable psychological factors in SCD, further research may reveal a modulatory effect of RNT on the relationship between cognition and brain integrity in SCD.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Aging ; Cognition ; Neuroimaging ; Repetitive negative thinking ; Risk factors ; Rumination ; Subjective cognitive decline
Published in:	Frontiers in aging neuroscience, Vol. 16 (2024) , p. 1441359, ISSN 1663-4365

DOI: 10.3389/fnagi.2024.1441359
PMID: 39193493

11 p, 1.4 MB

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