Few and nonsevere adverse infusion events using an automated method for diluting and washing before unrelated single cord blood transplantation
Castillo Flores, Nerea (Hospital Universitari Vall d'Hebron)
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau)
García, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Barba, Pere (Hospital Universitari Vall d'Hebron)
Diaz-Heredia, Cristina (Hospital Universitari Vall d'Hebron)
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau)
Azqueta, Carmen (Banc de Sang i Teixits (Barcelona, Catalunya))
Ferrá, Christelle (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Canals, Carme (Banc de Sang i Teixits (Barcelona, Catalunya))
Elorza Álvarez, Izaskun (Hospital Universitari Vall d'Hebron)
Olivé, Teresa (Hospital Universitari Vall d'Hebron)
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau)
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau)
Duarte, Rafael (Institut Català d'Oncologia)
Valcárcel, David (Hospital Universitari Vall d'Hebron)
Querol, Sergi (Banc de Sang i Teixits (Barcelona, Catalunya))
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2015
Abstract:	Graft dilution and DMSO washing before cord blood (CB) administration using an automated system may offer low incidence of adverse infusion events (AIE), ensuring reproducible cell yields. Hence, we analyzed the incidences and significance of immediate AIE, cellular yield, and engraftment after single CB infusion. One hundred and fifty-seven patients (median age, 20 years; range, 1 to 60) received a single CB unit for treatment of hematologic and nonhematologic malignancies with myeloablative conditioning after graft dilution and washing. The median total nucleated cell (TNC) doses was 3. 4× 10/kg (range, 2 to 26) and the median post-thaw recovery was 84% (range, 45 to 178). The cumulative incidence of neutrophil engraftment at 50 days was 84% (95% confidence interval [CI], 83 to 93). A total of 118 immediate AIE were observed in fifty-two (33%) patients. All reported AIE were transient, graded from 1 to 2 by Common Terminology Adverse Events version 4. The most frequent toxicity was cardiovascular but without any life-threatening reaction. Infused TNC, recipient's weight, and rate of infusion per kilogram were risk factors associated with cardiovascular AIE in multivariate analysis (odds ratio [OR], 1. 2 (95% CI, 1. 1 to 1. 4); P <. 001; OR,. 94 (95% CI,. 9 to. 97); P <. 001; and OR, 1. 5 (95% CI, 1. 2 to 1. 8); P <. 001; respectively). In summary, use of an automated method for graft washing before CB administration showed low incidence of AIE without compromising cell yields and engraftment. Infused TNC dose, recipient's weight, and rate of infusion per kilogram were risk factors associated with infusion reactions.
Grants:	Fundació la Marató de TV3 20133230
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Graft washing ; Safety ; Transplantation ; Umbilical cord blood
Published in:	Biology of blood and marrow transplantation, Vol. 21 Núm. 4 (january 2015) , p. 682-687, ISSN 1523-6536

DOI: 10.1016/j.bbmt.2014.12.015
PMID: 25545727

6 p, 368.7 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles