Strategies to assess the validity of recommendations : A study protocol
Martínez García, Laura (Institut d'Investigació Biomèdica Sant Pau)
Sanabria, Andrea Juliana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Araya, Ignacio (Universidad de Chile)
Lawson, Jennifer (McMaster University (Canadà))
Haynes, R.Brian (McMaster University (Canadà))
Rigau, David (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Solà, Ivan (Institut d'Investigació Biomèdica Sant Pau)
Díaz del Campo, Petra (Consejeria de Sanidad de Madrid. Subdirección General de Tecnología e Innovación Sanitarias)
Estrada Sabadell, M. Dolors (Agència de Qualitat i Avaluació Sanitàries de Catalunya)
Etxeandia-Ikobaltzeta, Itziar (Osteba, Basque Office for Health Technology Assessment)
García Álvarez, Elvira (Locum Consultant in Public Health Medicine (Swansea, Regne Unit))
Gracia, Javier (National Clinical Practice Guideline Programme of the NHS (Madrid))
Kotzeva, Anna (Agència de Qualitat i Avaluació Sanitàries de Catalunya)
Louro-González, Arturo (Xerencia de Xestión Integrada de A Coruña)
Salcedo-Fernandez, Flavia (Guía Salud-Aragon Institute of Health Sciences (Saragossa))
Trujillo-Martín, Maria Mar (Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC))
Alonso-Coello, Pablo (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Data:	2013
Resum:	Background: Clinical practice guidelines (CPGs) become quickly outdated and require a periodic reassessment of evidence research to maintain their validity. However, there is little research about this topic. Our project will provide evidence for some of the most pressing questions in this field: 1) what is the average time for recommendations to become out of date?; 2) what is the comparative performance of two restricted search strategies to evaluate the need to update recommendations?; and 3) what is the feasibility of a more regular monitoring and updating strategy compared to usual practice?. In this protocol we will focus on questions one and two. Methods: The CPG Development Programme of the Spanish Ministry of Health developed 14 CPGs between 2008 and 2009. We will stratify guidelines by topic and by publication year, and include one CPG by strata. We will develop a strategy to assess the validity of CPG recommendations, which includes a baseline survey of clinical experts, an update of the original exhaustive literature searches, the identification of key references (reference that trigger a potential recommendation update), and the assessment of the potential changes in each recommendation. We will run two alternative search strategies to efficiently identify important new evidence: 1) PLUS search based in McMaster Premium LiteratUre Service (PLUS) database; and 2) a Restrictive Search (ReSe) based on the least number of MeSH terms and free text words needed to locate all the references of each original recommendation. We will perform a survival analysis of recommendations using the Kaplan-Meier method and we will use the log-rank test to analyse differences between survival curves according to the topic, the purpose, the strength of recommendations and the turnover. We will retrieve key references from the exhaustive search and evaluate their presence in the PLUS and ReSe search results. Discussion: Our project, using a highly structured and transparent methodology, will provide guidance of when recommendations are likely to be at risk of being out of date. We will also assess two novel restrictive search strategies which could reduce the workload without compromising rigour when CPGs developers check for the need of updating. © 2013 Martínez García et al. ; licensee BioMed Central Ltd.
Ajuts:	Ministerio de Ciencia e Innovación CM11/00035 Ministerio de Economía y Competitividad CM12/00168 Ministerio de Ciencia e Innovación CP09/00137
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Clinical practice guidelines ; Diffusion of innovation ; Dissemination and implementation ; Evidence-based medicine ; Information storage and retrieval ; Knowledge translation ; Methodology ; Updating
Publicat a:	Implementation Science, Vol. 8 Núm. 1 (22 2013) , p. 94, ISSN 1748-5908

DOI: 10.1186/1748-5908-8-94
PMID: 23967896

8 p, 231.4 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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