Progression of Quality of Life in Patients with Plaque Psoriasis Who Achieved Three or More Years of Complete Skin Clearance with Guselkumab Treatment : a Post hoc Analysis of the VOYAGE 1 Clinical Trial
Puig Sanz, Lluís (Institut de Recerca Sant Pau)
Costanzo, Antonio (IRCCS Humanitas Clinical and Research Center (Milà, Itàlia))
de Jong, Elke M.G.J. (Radboud University Medical Center)
Torres, Tiago (University of Porto)
Warren, Richard B. (The University of Manchester)
Wapenaar, Robert (Janssen-Cilag BV)
Wegner, Sven (Janssen-Cilag GmbH)
Gorecki, Patricia (Janssen-Cilag Ltd)
Gramiccia, Talia (Janssen-Cilag SpA)
Jazra, Maria (Janssen-Cilag)
Buyze, Jozefien (Janssen Pharmaceutica NV)
Conrad, Curdin (Lausanne University Hospital CHUV and University of Lausanne)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	The interleukin-23p19 subunit inhibitor, guselkumab, has demonstrated improvements in clinical and patient-reported outcome (PRO) measures in patients with moderate-to-severe psoriasis. Understanding the relationship among clinical response, PRO measures and baseline characteristics could help clinicians individualize treatment plans. The objective of this analysis was to examine changes in signs, symptoms and quality-of-life (QoL) PRO measures in patients who maintained complete skin clearance through ≥ 3 years in the phase 3 VOYAGE 1 trial. Methods: A descriptive post hoc analysis of data from VOYAGE 1 was conducted to compare baseline characteristics of patients who maintained complete skin clearance (Psoriasis Area and Severity Index [PASI] = 0 for ≥ 156 consecutive weeks) versus patients who did not. Mean scores for individual domains of the Dermatology Life Quality Index (DLQI) and Psoriasis Symptom and Sign Diary (PSSD) were evaluated in patients who maintained complete skin clearance, and baseline characteristics of patients who achieved PRO scores of DLQI = 0/1 and PSSD = 0 were compared with those who did not. Results: Of the 329 patients included in this post hoc analysis, 73 (22. 2%) maintained PASI = 0 for ≥ 156 weeks. This group had a numerically lower proportion of patients at baseline with obesity, depression or previous biologic treatment and a higher proportion who had never smoked. Patients who maintained PASI = 0 generally achieved positive DLQI and PSSD outcomes, though some impact of residual disease was observed, largely related to the DLQI "Symptoms and feelings" sub-scale and PSSD components "Dryness," "Redness" and "Itch. " Patients reporting continued disease impact (despite sustaining PASI = 0) had greater disease severity at baseline versus those achieving DLQI = 0/1 and PSSD = 0. Conclusion: Clinical measures alone do not capture the full patient experience. While both QoL and clinical symptoms are responsive to highly effective treatment, a subset of patients with complete clinical response is still impacted by their psoriasis. Further investigation into this population is warranted. Trial registration: ClinicalTrials. gov, NCT02207231.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Biologics ; Clinical evaluation and treatment ; Psoriasis ; Quality of life
Publicat a:	Dermatology and Therapy, Vol. 14 Núm. 9 (september 2024) , p. 2539-2558, ISSN 2190-9172

DOI: 10.1007/s13555-024-01245-6
PMID: 39153060

20 p, 4.0 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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