An Overview of the Potential for Pharmacokinetic Interactions Between Drugs and Cannabis Products in Humans
Caicedo di Filippo, Dolly Andrea (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Farré Albaladejo, Magí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia

Date:	2025
Abstract:	Cannabis is the most commonly used illicit substance worldwide. Recent years have seen an increase in cannabis consumption, and with new approvals and therapeutic indications, there are challenges in minimizing the risks and interactions between cannabis-based products, cannabis prescription drugs, other approved prescription drugs, and other substances of abuse. Thus, identifying the enzymes metabolizing cannabinoid drugs and their relationship with other prescription drugs is crucial for understanding the potential interactions and effects of their simultaneous use. This article offers a comprehensive review of cannabis and the pharmacokinetic interactions between cannabis products, cannabis prescription drugs, and other approved prescription drugs, as well as other substances of abuse. It also compiles existing evidence of these interactions and describes the clinical outcomes associated with the inhibition or induction of various enzymes.
Grants:	Instituto de Salud Carlos III PI20/00804 Instituto de Salud Carlos III PI24/00660 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00945
Note:	Altres ajuts: Plataforma-UICEC PT20/00018; RICORS-RIAPAD (RD21/0009/0004 and RD24/0003/0019)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Cannabis ; Tetrahydrocannabinol ; THC ; Cannabidiol ; CBD ; Drug interactions ; Medicines ; Pharmacokinetics
Published in:	Pharmaceutics, Vol. 17, Núm. 3 (March 2025) , ISSN 1999-4923

DOI: 10.3390/pharmaceutics17030319
PMID: 40142983

32 p, 1.8 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles