Down Syndrome Biobank Consortium : A perspective
Aldecoa, Iban (Hospital Clínic i Provincial de Barcelona)
Barroeta, Isabel (Institut de Recerca Sant Pau)
Carroll, S.L. (Medical University of South Carolina)
Fortea, Juan (Institut de Recerca Sant Pau)
Gilmore, A. (University of Colorado Denver Anschutz Medical Campus)
Ginsberg, S.D. (New York University Grossman School of Medicine)
Guzman, S.J. (University of Colorado Anschutz Medical Campus)
Hamlett, E.D. (Medical University of South Carolina)
Head, E. (University of California Irvine)
Perez, S.E. (Barrow Neurological Institute)
Potter, H. (University of Colorado Denver Anschutz Medical Campus)
Molina-Porcel, Laura (Hospital Clínic i Provincial de Barcelona)
Raha-Chowdhury, R. (University of Cambridge)
Wisniewski, T. (New York University Grossman School of Medicine)
Yong, W.H. (University of California Irvine)
Zaman, S. (University of Cambridge)
Ghosh, S. (Cytogenetics and Genomics Research Unit)
Mufson, E.J. (Barrow Neurological Institute)
Granholm, A.C. (University of Colorado Denver Anschutz Medical Campus)
Universitat Autònoma de Barcelona

Data:	2024
Resum:	Individuals with Down syndrome (DS) have a partial or complete trisomy of chromosome 21, resulting in an increased risk for early-onset Alzheimer's disease (AD)-type dementia by early midlife. Despite ongoing clinical trials to treat late-onset AD, individuals with DS are often excluded. Furthermore, timely diagnosis or management is often not available. Of the genetic causes of AD, people with DS represent the largest cohort. Currently, there is a knowledge gap regarding the underlying neurobiological mechanisms of DS-related AD (DS-AD), partly due to limited access to well-characterized brain tissue and biomaterials for research. To address this challenge, we created an international consortium of brain banks focused on collecting and disseminating brain tissue from persons with DS throughout their lifespan, named the Down Syndrome Biobank Consortium (DSBC) consisting of 11 biobanking sites located in Europe, India, and the USA. This perspective describes the DSBC harmonized protocols and tissue dissemination goals.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Down syndrome ; Biobanking ; Brain banking ; Repository ; Research
Publicat a:	Alzheimer's & dementia, Vol. 20 Núm. 3 (march 2024) , p. 2262-2272, ISSN 1552-5279

DOI: 10.1002/alz.13692
PMID: 38270275

11 p, 8.1 MB

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