Real-World Experience in Tricuspid Transcatheter Edge-to-Edge Repair : Transcatheter Tricuspid Valve Repair in Spain Registry
Sisinni, Antonio (Universidade de Vigo)
Barreiro-Perez, Manuel (Universidade de Vigo)
Freixa, Xavier (Hospital Clínic i Provincial de Barcelona)
Arzamendi, Dabit (Institut de Recerca Sant Pau)
Moñivas, Vanessa (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Carrasco-Chinchilla, Fernando (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Pan Álvarez-Ossorio, Manuel (Hospital Universitario Reina Sofía (Córdoba, Espanya))
Nombela-Franco, Luís (Hospital Clínico San Carlos (Madrid))
Pascual, Isaac (Hospital Universitario Central de Asturias)
Benito-González, Tomás (Hospital Universitario de León)
Perez, Ruth (Hospital Universitario de A Coruña)
Gómez-Blázquez, Iván (Hospital Universitario 12 de Octubre (Madrid))
Amat-Santos, Ignacio J. (Hospital Clínic i Provincial de Barcelona)
Cruz-González, Ignacio (Hospital Universitario de Salamanca)
Sánchez-Recalde, Ángel (Hospital Universitario Ramón y Cajal (Madrid))
Cid Álvarez, Ana Belén (Hospital Clínic i Provincial de Barcelona)
Sanchis, Laura (Hospital Clínic i Provincial de Barcelona)
Caneiro-Queija, Berenice (Universidade de Vigo)
Li, Chi Hion (Institut de Recerca Sant Pau)
Del Trigo, M. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Martínez-Carmona, J.D. (Universidad de Málaga (UMA))
Mesa, Dolores (Hospital Universitario Reina Sofía (Córdoba, Espanya))
Pozo, Eduardo (Hospital Clínico San Carlos (Madrid))
Avanzas, Pablo (Hospital Universitario Central de Asturias)
Cepas-Guillén, Pedro (Hospital Clínic i Provincial de Barcelona)
Estevez-Loureiro, Rodrigo (Universidade de Vigo)
Universitat Autònoma de Barcelona

Data:	2025
Resum:	BACKGROUND: Significant tricuspid regurgitation (TR) is associated with increased morbidity and mortality. The development of transcatheter valve repair therapies has opened a wide range of opportunities for treatment of patients with high surgical risk. Real-world data might improve patient selection and outcome. The authors sought to investigate acute and short-term cardiovascular outcomes of tricuspid transcatheter edge-to-edge repair (T-TEER) with dedicated devices in a real-world setting. METHODS AND RESULTS: This is a retrospective, single-arm, multicenter registry conducted at 15 sites in Spain. The primary end point was a composite of all-cause death, rehospitalization for heart failure, and tricuspid valve re-intervention. Patients included (n=283) were older (76±9 years, 70% female), and showed significant comorbidities. Massive or torrential TR was present in 55% of subjects, with secondary cause being the main mechanism of regurgitation in ≈80% of individuals. Intraprocedural success was achieved in 79% of patients. At 1-year follow-up, significant improvements in TR grade (≥3+, 100% to 25%, P <0. 001) and New York Heart Association functional class (I/II, 33%-86%, P <0. 001) were observed. Lead-induced cause and single leaflet device attachment emerged as independent predictors of at least severe predischarge residual TR. In-hospital mortality occurred in 4 (1. 4%) patients, whereas the Kaplan-Meier estimated 1-year primary end point occurrence rate was 21%. Intraprocedural success (hazard ratio, 0. 353 [95% CI, 0. 156-0. 798]; P=0. 012), was found to be an independent predictor of primary end point. CONCLUSIONS: In a real-world contemporary setting, tricuspid transcatheter edge-to-edge repair with dedicated devices emerged as effective therapeutic option for patients with severe TR.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	TRI-SPA ; Edge-to-edge repair ; Procedural success ; Transcatheter treatment ; Tricuspid regurgitation
Publicat a:	Journal of the American Heart Association. Cardiovascular and cerebrovascular disease, Vol. 14 Núm. 2 (july 2025) , p. e037070, ISSN 2047-9980

DOI: 10.1161/JAHA.124.037070
PMID: 39818971

11 p, 1.2 MB

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