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15 p, 1.2 MB |
Kynurenic acid levels are increased in the CSF of Alzheimer's disease patients
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González-Sánchez, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Jiménez, Javier (Universidad de Alcalá) ;
Narváez García, Arantzazu (Universidad de Alcalá) ;
Antequera, Desiree (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Llamas-Velasco, Sara (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Herrero San-Martín, Alejandro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Molina Arjona, Jose Antonio (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Lopez de Munain, Adolfo (Biodonostia Osasun Ikerketako Institutura (País Basc)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Marco, María Pilar (Centro de Investigación Biomédica en Red (CIBER) de Bioingeniería. Biomateriales y Nanomedicina (CIBER-BBN)) ;
Rodríguez-Núñez, Montserrat (Centro de Investigación Biomédica en Red (CIBER) de Bioingeniería. Biomateriales y Nanomedicina (CIBER-BBN)) ;
Pérez-Martínez, David Andrés (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Villarejo-Galende, Alberto (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Bartolome, Fernando (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Domínguez, Elena (Universidad de Alcalá) ;
Carro, Eva M. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer's disease (AD). KYNA is primarily produced by astrocytes and is considered neuroprotective. [...]
2020 -  10.3390/biom10040571
Biomolecules, Vol. 10 Núm. 4 (april 2020) , p. 571
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18 p, 3.7 MB |
Neoadjuvant Chemotherapy plus Interval Cytoreductive Surgery with or without Hyperthermic Intraperitoneal Chemotherapy (NIHIPEC) in the Treatment of Advanced Ovarian Cancer : A Multicentric Propensity Score Study
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Llueca, Antoni (Department of Medicine, University Jaume I) ;
Ibañez, Maria Victoria (Department of Mathematics, University Jaume I) ;
Cascales, Pedro (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Gil-Moreno, Antonio 1965- (Vall d'Hebron Institut d'Oncologia) ;
Bebia, Vicente (Vall d'Hebron Institut d'Oncologia) ;
Ponce, Jordi (Department of Gynecology, University Hospital of Bellvitge) ;
Fernández-González, Sergi (Department of Gynecology, University Hospital of Bellvitge, 08907 Barcelona, Spain; (J.P.); (S.F.)) ;
Arjona-Sanchez, Alvaro (University Hospital Reina Sofia) ;
Muruzabal, Juan Carlos (Department of Gynecologic Oncology, Complejo Hospitalario de Navarra) ;
Veiga, Nadia (Department of Gynecologic Oncology, Complejo Hospitalario de Navarra) ;
Díaz-Feijoo, Berta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Celada, Cristina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gilabert-Estelles, Juan (Department of Obstetrics and Gynecology, University General Hospital of Valencia) ;
Aghababyan, Cristina (Department of Obstetrics and Gynecology, University General Hospital of Valencia) ;
Lacueva, Javier (Department of General Surgery, University General Hospital of Elche) ;
Calero, Alicia (Department of General Surgery, University General Hospital of Elche) ;
Segura-Sampedro, Juan José (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Maiocchi, Karina (Department of General Surgery, University General Hospital of Castellon) ;
Llorca, Sara (Department of General Surgery, University General Hospital of Castellon) ;
Villarin, Alvaro (Department of General Surgery, University General Hospital of Castellon) ;
Climent, Maria Teresa (Department of Medicine, University Jaume I) ;
Delgado, Katty (Department of Medicine, University Jaume I) ;
Serra Rubert, Anna (Department of Medicine, University Jaume I) ;
Gomez-Quiles, Luis (Department of General Surgery, University General Hospital of Castellon) ;
Llueca, Maria (Hospital Universitari Joan XXIII de Tarragona) ;
Universitat Autònoma de Barcelona
Advanced ovarian cancer (Stages III-IV) continues to be one of the gynecological tumors with the highest mortality. Standard treatment consists of debulking surgery and subsequent adjuvant chemotherapy. [...]
2023 - 10.3390/cancers15174271
Cancers, Vol. 15 (august 2023)
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9 p, 880.5 KB |
Management of cerebral venous thrombosis in Spain : MOTIVATE descriptive study Manejo de la trombosis venosa cerebral en España: estudio descriptivo MOTIVATE
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Pérez Lázaro, C. (Instituto de Investigación Sanitaria de Aragón) ;
López-Bravo, A. (Instituto de Investigación Sanitaria de Aragón) ;
Gómez-Escalonilla Escobar, C. (Hospital Clínico San Carlos (Madrid)) ;
Aguirre, Clara (Hospital Universitario de la Princesa (Madrid)) ;
de Felipe, A. (Hospital Universitario Ramón y Cajal (Madrid)) ;
de la Riva, Pere (Hospital Universitario Donosti) ;
Calleja, S. (Hospital Universitario Central de Asturias) ;
Arjona, A. (Hospital Universitario Torrecárdenas) ;
Serrano Ponz, M. (Hospital Universitario Miguel Servet (Saragossa)) ;
Navarro-Pérez, M.P. (Instituto de Investigación Sanitaria de Aragón) ;
Delgado Mederos, Raquel (Institut d'Investigació Biomèdica Sant Pau) ;
Bashir Viturro, S. (Hospital Universitari de Girona Doctor Josep Trueta) ;
Llul, L. (Hospital Clínic i Provincial de Barcelona) ;
Egido, J. (Hospital Clínico San Carlos (Madrid)) ;
García Madrona, S. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Díez González, N. (Hospital Universitario Donosti) ;
Benavente Fernández, L. (Hospital Universitario Central de Asturias) ;
de la Torre Colmenero, J.D. (Hospital Universitario Torrecárdenas) ;
Tejada Meza, H. (Hospital Universitario Miguel Servet (Saragossa)) ;
Vesperinas Castro, A. (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez Cirera, L. (Hospital Universitari de Girona Doctor Josep Trueta) ;
Trillo, S. (Hospital Universitario de la Princesa (Madrid))
Introduction: Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults. Early, accurate diagnosis can reduce the rate and severity of complications. Objective: The aim of this study was to analyse the clinical characteristics, management, and treatment of CVT in different centres in Spain. [...]
2021 - 10.1016/j.nrl.2021.05.016
Neurología, 2021
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12 p, 4.1 MB |
NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
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Tu, Shichun (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Akhtar, Mohd Waseem (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Escorihuela, Rosa M (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Amador-Arjona, Alejandro (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Swarup, Vivek (University of California. Center for Autism Research and Treatment (CART)) ;
Parker, James (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Zaremba, Jeffrey D. (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Holland, Timothy (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Bansal, Neha (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Holohan, Daniel R. (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Lopez, Kevin (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Ryan, Scott D. (Department of Molecular and Cellular Biology, University of Guelph, Guelph, Canada) ;
Chan, Shing Fai (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Yan, Li (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Zhang, Xiaofei (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Huang, Xiayu (Sanford Burnham Prebys Medical Discovery Institute. Bioinformatics Core Facility) ;
Sultan, Abdullah (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
McKercher, Scott R. (The Scripps Research Institute. Department of Molecular Medicine and Neuroscience, Neuroscience Translational Center) ;
Ambasudhan, Rajesh (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Xu, Huaxi (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Wang, Yuqiang (Jinan University College of Pharmacy. Institute of New Drug Research) ;
Geschwind, Daniel H. (University of California. Center for Autism Research and Treatment (CART)) ;
Roberts, Amanda J. (The Scripps Research Institute. Department of Neuroscience and Mouse Behavioral Assessment Core) ;
Terskikh, Alexey V. (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center) ;
Rissman, Robert A. (Veterans Affairs San Diego Healthcare System) ;
Masliah, Eliezer (Department of Neurosciences, University of California) ;
Lipton, Stuart A. (University of California, San Diego, School of Medicine. Department of Neurosciences) ;
Nakanishi, Nobuki (Sanford Burnham Prebys Medical Discovery Institute. Neuroscience and Aging Research Center)
Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD), and human MEF2C haploinsufficiency results in ASD, intellectual disability, and epilepsy. However, molecular mechanisms underlying MEF2C haploinsufficiency syndrome remain poorly understood. [...]
2017 - 10.1038/s41467-017-01563-8
Nature communications, Vol. 8 (november 2017)
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16 p, 1020.6 KB |
Transgenic mice overexpressing the full-length neurotrophin receptor TrkC exhibit increased catecholaminergic neuron density in specific brain areas and increased anxiety-like behavior and panic reaction
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Dierssen, Mara (Centre de Regulació Genòmica) ;
Gratacòs, Mònica (Centre de Regulació Genòmica) ;
Sahún, Ignasi (Centre de Regulació Genòmica) ;
Martin, Miquel (Universitat Pompeu Fabra. Àrea de Neurofarmacologia) ;
Gallego, Xavier (Centre de Regulació Genòmica) ;
Amador-Arjona, Alejandro (Centre de Regulació Genòmica) ;
Martínez de Lagrán, María (Centre de Regulació Genòmica) ;
Murtra, Patricia (Universitat Pompeu Fabra. Àrea de Neurofarmacologia) ;
Martí, Eulalia (Centre de Regulació Genòmica) ;
Pujana, Miguel A.. (Centre de Regulació Genòmica) ;
Ferrer, Isidro (Hospital Prínceps d'Espanya. Àrea de neuropatologia) ;
Dalfo, Esther (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Martínez-Cué, Carmen (Universidad de Cantabria. Departamento de Psicologia y Farmacologia) ;
Flórez, Jesús (Universidad de Cantabria. Departamento de Psicologia y Farmacologia) ;
Torres-Peraza, Jesús F. (Universitat de Barcelona. Departament de Biologia Cel·lular i Anatomia Patològica) ;
Alberch i Vié, Jordi (Universitat de Barcelona. Departament de Biologia Cel·lular i Anatomia Patològica) ;
Maldonado, Rafael 1961- (Universitat Pompeu Fabra. Àrea de Neurofarmacologia) ;
Fillat, Cristina (Centre de Regulació Genòmica) ;
Estivill, Xavier (Centre de Regulació Genòmica)
Accumulating evidence has suggested that neurotrophins participate in the pathophysiology of mood disorders. We have developed transgenic mice overexpressing the full-length neurotrophin-3 receptor TrkC (TgNTRK3) in the central nervous system. [...]
2006 - 10.1016/j.nbd.2006.07.015
Neurobiology of disease, Vol. 24, Num. 2 (2006) , p. 403-18
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