Results overview: Found 9 records in 0.01 seconds.
Articles, 8 records found
Research literature, 1 records found
Articles 8 records found  
1.
13 p, 1.3 MB Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis / Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez-Barriocanal, Águeda (IRBLleida. Group of Molecular Oncology) ; Anguita, Estefanía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Li, Jing (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Vidal, Elia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Maggio, Valentina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Aaltonen, Lauri A. (University of Helsinki) ; Sánchez, Alex (Universitat de Barcelona. Departament d'Estadística) ; Mariadason, John M. (La Trobe University. School of Cancer Medicine) ; Arango, Diego (IRBLleida. Group of Molecular Oncology)
Cancer initiation and progression are driven by genetic and epigenetic changes. Although genome/exome sequencing has significantly contributed to the characterization of the genetic driver alterations, further investigation is required to systematically identify cancer driver genes regulated by promoter hypermethylation. [...]
2021 - 10.1186/s13148-021-01070-0
Clinical Epigenetics, Vol. 13 (april 2021)  
2.
13 p, 3.2 MB Role of ADAM17 in the non-cell autonomous effects of oncogene-induced senescence / Morancho, Beatriz (Vall d'Hebron Institut d'Oncologia) ; Martínez-Barriocanal, Águeda (Vall d'Hebron Institut d'Oncologia) ; Villanueva, Josep (Vall d'Hebron Institut d'Oncologia) ; Arribas, Joaquín V (Vall d'Hebron Institut d'Oncologia) ; Universitat Autònoma de Barcelona
Cellular senescence is a terminal cell proliferation arrest that can be triggered by oncogenes. One of the traits of oncogene-induced senescence (OIS) is the so-called senescence-associated secretory phenotype or senescence secretome. [...]
2015 - 10.1186/s13058-015-0619-7  
3.
12 p, 5.0 MB Patterns of HER2 Gene Amplification and Response to Anti-HER2 Therapies / Vicario, Rocío (Vall d'Hebron Institut d'Oncologia) ; Peg, Vicente (Hospital Universitari Vall d'Hebron) ; Morancho, Beatriz (Vall d'Hebron Institut d'Oncologia) ; Zacarías-Fluck, Mariano F (Vall d'Hebron Institut d'Oncologia) ; Zhang, Junjie (Vall d'Hebron Institut d'Oncologia) ; Martínez-Barriocanal, Águeda (Vall d'Hebron Institut d'Oncologia) ; Navarro Jiménez, Alexandra (Hospital Universitari Vall d'Hebron) ; Aura, Claudia (Vall d'Hebron Institut d'Oncologia) ; Burgués, Octavio (Hospital Clínic Universitari (València)) ; Lluch, Ana (Hospital Clínic Universitari (València)) ; Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ; Nuciforo, Paolo (Vall d'Hebron Institut d'Oncologia) ; Rubio, Isabel T. (Vall d'Hebron Institut d'Oncologia) ; Marangoni, Elisabetta (Institut Curie) ; Deeds, James (Novartis Oncology Translational Research (Estats Units d'Amèrica)) ; Boehm, Markus (Novartis Pharma AG (Suïssa)) ; Schlegel, Robert (Novartis Oncology Translational Research (Estats Units d'Amèrica)) ; Boehm, Markus (Novartis Pharma AG (Suïssa)) ; Tabernero, Josep (Vall d'Hebron Institut d'Oncologia) ; Mosher, Rebecca (Novartis Oncology Translational Research (Estats Units d'Amèrica)) ; Boehm, Markus (Novartis Pharma (Suïssa)) ; Arribas, Joaquín V (Institució Catalana de Recerca i Estudis Avançats) ; Universitat Autònoma de Barcelona
A chromosomal region that includes the gene encoding HER2, a receptor tyrosine kinase (RTK), is amplified in 20% of breast cancers. Although these tumors tend to respond to drugs directed against HER2, they frequently become resistant and resume their malignant progression. [...]
2015 - 10.1371/journal.pone.0129876
PloS one, Vol. 10 (june 2015)  
4.
17 p, 3.6 MB The Receptor CMRF35-Like Molecule-1 (CLM-1) Enhances the Production of LPS-Induced Pro-Inflammatory Mediators during Microglial Activation / Ejarque-Ortiz, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Solà, Carme (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Martínez-Barriocanal, Águeda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Schwartz, Simó (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martín, Margarita (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Peluffo, Hugo (Institut Pasteur de Montevideo) ; Sayós, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
CMRF35-like molecule-1 (CLM-1) belongs to a receptor family mainly expressed in myeloid cells that include activating and inhibitory receptors. CLM-1 contains two ITIMs and a single immunoreceptor tyrosine-based switch motif (ITSM), although also displays a binding site for p85α regulatory subunit of PI3K. [...]
2015 - 10.1371/journal.pone.0123928
PloS one, Vol. 10 (april 2015)  
5.
11 p, 3.7 MB Effect of Specific Mutations in Cd300 Complexes Formation; Potential Implication of Cd300f in Multiple Sclerosis / Martínez-Barriocanal, Águeda (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Arcas-García, Andrea (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Magallon-Lorenz, Miriam (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Ejarque-Ortiz, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Negro-Demontel, María Luciana (Neuroinflammation and Gene Therapy Laboratory, Institut Pasteur Montevideo) ; Comas-Casellas, Emma (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Schwartz, Simo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Malhotra, Sunny (Hospital Universitari Vall d'Hebron) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Peluffo, Hugo (UDELAR) ; Martín, Margarita (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Comabella, Manuel ; Sayós, Joan (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Universitat Autònoma de Barcelona
Herein, we have used bioinformatics tools to predict five clusters defining ligand-binding sites on the extracellular domain of human CD300b receptor, presumably involved in the formation of both homodimers and heterodimers with other CD300 family members. [...]
2017 - 10.1038/s41598-017-12881-8
Scientific reports, Vol. 7 (october 2017)  
6.
14 p, 2.1 MB Investigation of the role of tyrosine kinase receptor EPHA3 in colorectal cancer / Andretta, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez-Barriocanal, Águeda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jimenez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Landolfi, Stefania (Hospital Universitari Vall d'Hebron) ; Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron) ; Schwartz, Simo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Brown, Arthur (Robarts Research Institute) ; Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
EPH signaling deregulation has been shown to be important for colorectal carcinogenesis and genome-wide sequencing efforts have identified EPHA3 as one of the most frequently mutated genes in these tumors. [...]
2017 - 10.1038/srep41576
Scientific reports, Vol. 7 (02 2017)  
7.
16 p, 2.8 MB PVT1 Long Non-coding RNA in Gastrointestinal Cancer / Martínez-Barriocanal, Águeda (Hospital Universitari Vall d'Hebron) ; Arango, Diego (Hospital Universitari Vall d'Hebron) ; Dopeso, Higinio (Hospital Universitari Vall d'Hebron)
Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the regulation of critical signaling pathways including cell growth, motility, apoptosis, and differentiation; and their expression has been found dysregulated in human tumors. [...]
2020 - 10.3389/fonc.2020.00038
Frontiers in Oncology, Vol. 10 (january 2020)  
8.
11 p, 1.5 MB Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer / Dopeso, Higinio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rodrigues, Paulo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bilic Zimmermann, Josipa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Bazzocco, Sarah (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Cartón-Garcia, Fernando (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Macaya, Irati (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Marcondes, Priscila Guimarães (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Anguita, Estefanía (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Masanas, Marc (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Jiménez-Flores, Lizbeth M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Martínez-Barriocanal, Águeda (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Nieto Raya, Rocio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Segura, Miguel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Schwartz Jr, Simo (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Mariadason, John M. (La Trobe University School of Cancer Medicine, Olivia Newton-John Cancer Research Institute) ; Arango, Diego (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
Reduced RHOA signalling has been shown to increase the growth/metastatic potential of colorectal tumours. However, the mechanisms of inactivation of RHOA signalling in colon cancer have not been characterised. [...]
2017 - 10.1038/bjc.2017.420
British Journal of Cancer, Vol. 118 (december 2017) , p. 106-116  

Research literature 1 records found  
1.
237 p, 5.6 MB The Small GTPase RHOA in cancer / Anguita, Estefanía ; Arango, Diego, dir. ; Martínez Barriocanal, Agueda, dir. ; Dopeso Gonzalez, Jose Higinio, dir.
RhoA és una proteïna GTPasa amb un paper rellevant en importants processos cel·lulars. Els nivells d'expressió de RhoA i/o la seva activitat es troben alterats en molts tipus de càncer, però curiosament s'han trobat mutacions recurrents i específiques de tumor en càncer gàstric de tipus difús (CGD), carcinoma de cèl·lules escamoses de cap i coll (CCECC), limfoma de Burkitt, leucèmia/limfoma T de l'adult i limfoma T angioimmunoblàstic, suggerint un paper diferent y depenent de tumor per cada proteïna mutant. [...]
RhoA es una proteína GTPasa con un papel relevante en importantes procesos celulares. Los niveles de expresión de RhoA y/o su actividad se encuentran alterados en muchos tipos de cáncer, pero curiosamente, se han encontrado mutaciones recurrentes y específicas de tumor en cáncer gástrico de tipo difuso (CGD), carcinoma de células escamosas de cabeza y cuello (CCECC), linfoma de Burkitt, leucemia/linfoma T del adulto y linfoma T angioinmunoblástico, sugiriendo un papel distinto y dependiente de tumor para cada proteína mutante. [...]
RhoA is a small GTPase with an important role in key cellular processes. RhoA expression levels and/or activity are altered in multiple cancers, but interestingly, recurrent and tissue-specific hotspot mutations have been recently identified in diffuse gastric cancer (DGC), head and neck squamous cell carcinoma (HNSCC), Burkitt lymphoma, adult T-cell leukemia/lymphoma and angioimmunoblastic T-cell lymphoma, suggesting a distinctive and tumor-dependent role of each mutant protein. [...]

2022  

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