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1.
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10 p, 666.8 KB |
Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain
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Arriola, Edurne (Hospital del Mar (Barcelona, Catalunya)) ;
García Gómez, Ramón (Hospital General Universitario Gregorio Marañón) ;
Diz Taín, Pilar (Hospital Universitario de León) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez Aguillo, Maite (Complejo Hospitalario de Navarra) ;
Valdivia, Javier (Hospital Universitario Virgen de las Nieves (Granada)) ;
Paredes, Alfredo (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Sánchez-Torres, José Miguel (Hospital Universitario de la Princesa (Madrid)) ;
Peralta Muñoz, Sergio (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Barneto Aranda, Isidoro (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
Gutierrez, Vanesa (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Andrade Santiago, Jesús Manuel (Hospital Virgen de la Salud (Toledo)) ;
Aparisi, Francisco (Hospital Virgen de los Lirios) ;
Isla, Dolores (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Ponce, Santiago (Hospital 12 de Octubre (Madrid)) ;
Vicente Baz, David (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Artal, Ángel (Hospital Universitario Miguel Servet (Saragossa)) ;
Amador, Mariluz (AstraZeneca) ;
Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Universitat Autònoma de Barcelona
Although the benefit of first-line epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) over chemotherapy has been demonstrated in several clinical trials, data from clinical practice is lacking and the optimal EGFR TKI to be used remains unclear. [...]
2018 -  10.1186/s12885-018-4004-7
BMC Cancer, Vol. 18 Núm. 1 (30 2018) , p. 106
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2.
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15 p, 510.1 KB |
Clinical and Laboratory Features in Anti-NF155 Autoimmune Nodopathy
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Martín-Aguilar, Lorena (Institut d'Investigació Biomèdica Sant Pau) ;
Lleixà, Cinta (Institut d'Investigació Biomèdica Sant Pau) ;
Pascual-Goñi, Elba (Institut d'Investigació Biomèdica Sant Pau) ;
Caballero-Ávila, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Martinez-Martinez, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Rojas-Garcia, Ricard (Institut d'Investigació Biomèdica Sant Pau) ;
Cortés-Vicente, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Turon-Sans, Janina (Institut d'Investigació Biomèdica Sant Pau) ;
De Luna, Noemi (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Suarez-Calvet, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
Gallardo, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Rajabally, Yusuf (Birmingham Women's and Children's Hospital (Regne Unit)) ;
Scotton, Sangeeta (Birmingham Women's and Children's Hospital (Regne Unit)) ;
Jacobs, Bart C. (Erasmus Medical Center) ;
Baars, Adája (Erasmus Medical Center) ;
Cortese, Andrea (Irccs Mondino Foundation) ;
Vegezzi, Elisa (Irccs Mondino Foundation) ;
Höftberger, Romana (Department of Neurology. Medical University of Vienna) ;
Zimprich, Fritz (Department of Neurology. Medical University of Vienna) ;
Roesler, Cornelia (Paracelsus Medical University) ;
Nobile-Orazio, Eduardo (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Liberatore, Giuseppe (Irccs Humanitas Research Hospital. Milan University) ;
Hiew, Fu Liong (Kuala Lumpur General Hospital) ;
Martínez-Piñeiro, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carvajal, Alejandra (Hospital Universitario Virgen de las Nieves (Granada)) ;
Piñar-Morales, Raquel (Hospital Universitario San Cecilio (Granada)) ;
Usón-Martín, Mercedes (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Albertí, Olalla (Hospital General San Jorge (Osca)) ;
López Pérez, María Ángeles (Hospital San Pedro de Alcántara) ;
Márquez, Fabian (Hospital Universitari de Girona Doctor Josep Trueta) ;
Pardo-Fernández, Julio (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Muñoz-Delgado, Laura (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Cabrera-Serrano, Macarena (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Ortiz-Castellon, Nicolau (Hospital Universitari de Sant Joan de Reus (Tarragona)) ;
Bartolomé, Manuel (Complejo Asistencial de Ávila) ;
Duman, Özgür (Akdeniz University) ;
Bril, Vera (Toronto General Hospital. University Health Network. University of Toronto) ;
Segura-Chávez, Darwin (Instituto Nacional de Ciencias Neurológicas) ;
Pitarokoili, Kalliopi (St. Josef-Hospital. Ruhr-University Bochum) ;
Steen, Claudia (Sant Joseph Hospital) ;
Illa, Isabel (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background and ObjectivesTo study the clinical and laboratory features of antineurofascin-155 (NF155)-positive autoimmune nodopathy (AN). MethodsPatients with anti-NF155 antibodies detected on routine immunologic testing were included. [...]
2022 - 10.1212/NXI.0000000000001098
Neurology® neuroimmunology & neuroinflammation, Vol. 9 Núm. 1 (february 2022) , p. e1098
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3.
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28 p, 884.5 KB |
Cabozantinib for the treatment of solid tumors : a systematic review
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Maroto Rey, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Porta, Camillo (Interdisciplinary Department of Medicine. University of Bari "Aldo Moro) ;
Capdevila Castillón, Jaume (Vall d'Hebron Institut d'Oncologia) ;
Apolo, Andrea B. (Center for Cancer Research. National Cancer Institute. National Institutes of Health) ;
Viteri, Santiago (UOMI Cancer Center. Clínica Mi Tres Torres) ;
Rodriguez-Antona, Cristina (Centro Nacional de Investigaciones Oncológicas Carlos III (Espanya)) ;
Martin, Lidia (Ipsen Pharma) ;
Castellano, Daniel (Hospital Universitario 12 de Octubre. Servicio de Oncología Médica)
Background: Cabozantinib is approved, in various settings, for the treatment of renal cell carcinoma, medullary thyroid cancer, and hepatocellular carcinoma, and it has been investigated for the treatment of other cancers. [...]
2022 - 10.1177/17588359221107112
Therapeutic Advances in Medical Oncology, Vol. 14 (2022)
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4.
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13 p, 1.1 MB |
IgG4 Valency Modulates the Pathogenicity of Anti-Neurofascin-155 IgG4 in Autoimmune Nodopathy
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Jentzer, Alexandre (Department of Immunology. CHU Montpellier) ;
Attal, Arthur (Department of Neurology. CHU Montpellier. Hôpital Gui de Chauliac) ;
Roué, Clémence (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Raymond, Julie (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Lleixà, Cinta (Institut d'Investigació Biomèdica Sant Pau) ;
Illa, Isabel (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau) ;
Taieb, Guillaume (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Devaux, Jérôme (Institut de Génomique Fonctionnelle. CNRS UMR5203) ;
Universitat Autònoma de Barcelona
Background and Objective s : IgG4 autoantibodies to neurofascin-155 (Nfasc155) are associated with a subgroup of patients with chronic inflammatory demyelinating polyneuropathy (CIDP), currently named autoimmune nodopathy. [...]
2022 - 10.1212/NXI.0000000000200014
Neurology® neuroimmunology & neuroinflammation, Vol. 9 Núm. 5 (october 2022) , p. e200014
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5.
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37 p, 420.1 KB |
Cabozantinib combination therapy for the treatment of solid tumors : a systematic review
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Castellano, Daniel (Hospital Universitario 12 de Octubre (Madrid)) ;
Apolo, Andrea B. (Center for Cancer Research. National Cancer Institute. National Institutes of Health) ;
Porta, Camillo (Interdisciplinary Department of Medicine. University of Bari 'Aldo Moro') ;
Capdevila Castillón, Jaume (Vall d'Hebron Institut d'Oncologia) ;
Viteri, Santiago (Instituto Oncológico Dr. Rosell) ;
Rodriguez-Antona, Cristina (Centro Nacional de Investigaciones Oncológicas) ;
Martin, Lidia (Ipsen Pharma) ;
Maroto Rey, Pablo (Institut d'Investigació Biomèdica Sant Pau)
Background: Cabozantinib monotherapy is approved for the treatment of several types of solid tumors. Investigation into the use of cabozantinib combined with other therapies is increasing. To understand the evidence in this area, we performed a systematic review of cabozantinib combination therapy for the treatment of solid tumors in adults. [...]
2022 - 10.1177/17588359221108691
Therapeutic Advances in Medical Oncology, Vol. 14 (2022)
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6.
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14 p, 586.6 KB |
Comprehensive cross-platform comparison of methods for non-invasive EGFR mutation testing : results of the RING observational trial
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Romero, Atocha (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Jantus-Lewintre, Eloisa (Universitat Politècnica de València) ;
García-Peláez, Beatriz (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Royuela, Ana (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Insa, Amelia (Hospital Clínic Universitari (València)) ;
Cruz Castellanos, Patricia (Hospital Universitario La Paz (Madrid)) ;
Collazo-Lorduy, Ana (Hospital Universitario HM Sanchinarro (Madrid)) ;
Pérez Altozano, Javier (Hospital Virgen de los Lirios) ;
Vidal, Oscar Juan (Hospital Universitari i Politècnic La Fe (València)) ;
Diz Taín, P (Complejo Asistencial Universitario de León) ;
Cobo, Manuel (Hospital Regional Universitario de Málaga) ;
Hernández, Berta (Complejo Hospitalario de Navarra) ;
Vázquez Estevez, Sergio (Hospital Universitario Lucus Augusti (Lugo)) ;
Benítez, Gretel (Complejo Hospitalario Universitario Insular de Gran Canaria) ;
Guirado, Maria (Hospital General Universitario de Elche) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Bernabé, Reyes (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Ortega Granados, Ana Laura (Complejo Hospitalario de Jaén) ;
Blasco, Ana (Centro de Investigación Biomédica en Red de Cáncer) ;
Bosch-Barrera, J (Institut d'Investigació Biomèdica de Girona) ;
Jurado, Jose M. (Hospital Universitario San Cecilio (Granada)) ;
García González, Jorge (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Viteri, Santiago (Instituto Oncológico Dr. Rosell. Hospital Universitario Dexeus. Grupo Quiron Salud) ;
Garcia Giron, Carlos (Hospital Universitario de Burgos) ;
Massuti, Bartomeu (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Lopez Martín, Ana (Hospital Universitario Severo Ochoa) ;
Rodriguez-Festa, Alejandro (Fundación de Investigación Biomédica del H.U. Puerta de Hierro Majadahonda) ;
Calabuig-Fariñas, Silvia (Universitat de València. Departament de Patologia) ;
Molina-Vila, Miguel Ángel (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Provencio, Mariano (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Several platforms for noninvasive EGFR testing are currently used in the clinical setting with sensitivities ranging from 30% to 100%. Prospective studies evaluating agreement and sources for discordant results remain lacking. [...]
2021 - 10.1002/1878-0261.12832
Molecular Oncology, Vol. 15 Núm. 1 (january 2021) , p. 43-56
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7.
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48 p, 1.4 MB |
Coating bioactive microcapsules with tannic acid enhances the phenotype of the encapsulated pluripotent stem cells
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Choi, Daheui (Mayo Clinic, Department of Physiology and Biomedical Engineering) ;
Gwon, Kihak (Mayo Clinic. Department of Physiology and Biomedical Engineering) ;
Hong, Hye Jin (Mayo Clinic. Department of Physiology and Biomedical Engineering) ;
Baskaran, Harihara (Case Western Reserve University. Department of Chemical and Biomolecular Engineering) ;
Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ;
Gonzalez-Suarez, Alan M. (Mayo Clinic. Department of Physiology and Biomedical Engineering) ;
Park, Kyungtae (Yonsei University. Department of Chemical and Biomolecular Engineering) ;
De Hoyos-Vega, Jose M. (Mayo Clinic. Department of Physiology and Biomedical Engineering) ;
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia) ;
Hong, Jinkee (Yonsei University. Department of Chemical and Biomolecular Engineerin) ;
Stybayeva, Gulnaz (Mayo Clinic. Department of Physiology and Biomedical Engineering) ;
Revzin, Alexander (Mayo Clinic. Department of Physiology and Biomedical Engineering)
Human pluripotent stem cells (hPSCs) may be differentiated into any adult cell type and therefore hold incredible promise for cell therapeutics and disease modeling. There is increasing interest in three-dimensional (3D) hPSC culture because of improved differentiation outcomes and potential for scale up. [...]
2022 - 10.1021/acsami.2c06783
ACS applied materials & interfaces, Vol. 14, issue 23 (June 2022) , p. 27274-27286
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8.
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10 p, 616.7 KB |
Treatment strategy optimization for patients with non-small-cell lung cancer harboring EGFR mutation : a Delphi consensus
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Isla, Dolores (Instituto de Investigación Sanitaria de Aragón) ;
De Castro Carpeño, Javier (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
García-Campelo, R. (Complejo Hospitalario Universitario de A Coruña) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Vicente, David (Hospital Universitario Virgen Macarena (Sevilla, Andalusia)) ;
Juan, Óscar (Hospital Universitari i Politècnic La Fe (València))
Aim: To stablish a consensus on the treatment strategy for advanced non-small-cell lung cancer (aNSCLC) with epidermal growth factor receptor mutation (EGFRm) in Spain. Methods: After a systematic literature review, the scientific committee developed 33 statements in 4 fields: molecular diagnosis (10 items); histologic profile and patient clinical characteristics (7 items); first-line (1L) treatment in EGFRm aNSCLC (8 items); and subsequent-line treatment (8 items). [...]
2021 - 10.1007/s12094-020-02518-0
Clinical & Translational Oncology, Vol. 23 Núm. 7 (july 2021) , p. 1304-1313
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9.
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16 p, 2.5 MB |
Semen Modulates Cell Proliferation and Differentiation-Related Transcripts in the Pig Peri-Ovulatory Endometrium
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Gardela Santacruz, Jaume (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Ruiz Conca, Mateo (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Wright, Dominic (Linköping University. Department of Physics, Chemistry and Biology) ;
López Béjar, Manel (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Martinez, Cristina A (Linköping University. Department of Biomedical & Clinical Sciences) ;
Rodriguez-Martinez, Heriberto (Linköping University. Department of Biomedical & Clinical Sciences) ;
Álvarez-Rodríguez, Manuel (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Homeostasis of the uterus after mating is crucial for the subsequent reproductive events. The post-mating inflammatory response is restricted to the uterus, but semen also modulates the expression of other genes involved in regulation along the female reproductive tract, including the oviduct. [...]
2022 - 10.3390/biology11040616
Biology, Vol. 11 (april 2022)
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10.
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14 p, 2.7 MB |
Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist
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Moreau, Francois (Harvard Medical School. Joslin Diabetes Center) ;
Kirk, Nicholas S. (University of Melbourne. Department of Medical Biology) ;
Zhang, Fa (Indiana University. Department of Chemistry) ;
Gelfanov, Vasily (Indianapolis Research Center) ;
List, Edward O. (Ohio University. Edison Biotechnology Institute and Heritage College of Osteopathic Medicine) ;
Chrudinová, Martina (Boston College Biology Department) ;
Venugopal, Hari (Monash University. Ramaciotti Centre for Cryo-Electron Microscopy) ;
Lawrence, Michael C. (University of Melbourne. Department of Medical Biology) ;
Jimenez, Veronica (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ;
Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ;
Kopchick, John J. (Ohio University. Edison Biotechnology Institute and Heritage College of Osteopathic Medicine) ;
DiMarchi, Richard D. (Indiana University. Department of Chemistry) ;
Altindis, Emrah (Boston College Biology Department) ;
Ronald Kahn, C. (Harvard Medical School. Joslin Diabetes Center)
Lymphocystis disease virus-1 (LCDV-1) and several other Iridoviridae encode viral insulin/IGF-1 like peptides (VILPs) with high homology to human insulin and IGFs. Here we show that while single-chain (sc) and double-chain (dc) LCDV1-VILPs have very low affinity for the insulin receptor, scLCDV1-VILP has high affinity for IGF1R where it can antagonize human IGF-1 signaling, without altering insulin signaling. [...]
2022 - 10.1038/s41467-022-34391-6
Nature communications, Vol. 13 (november 2022)
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