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11 p, 396.3 KB |
Pomalidomide, bortezomib, and dexamethasone at first relapse in lenalidomide-pretreated myeloma : A subanalysis of OPTIMISMM by clinical characteristics
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Richardson, Paul G.. (Department of Medical Oncology. Harvard Medical School) ;
Schjesvold, Fredrik (University of Oslo) ;
Weisel, Katja (University Medical Center Hamburg-Eppendorf) ;
Moreau, Philippe (University Hospital Hôtel-Dieu) ;
Anderson, Larry D. (University of Texas Southwestern Medical Center) ;
White, Darrell (Dalhousie University and Queen Elizabeth II Health Sciences Centre) ;
Rodriguez-Otero, Paula (Clínica Universidad de Navarra) ;
Sonneveld, Pieter (Erasmus MC Cancer Institute) ;
Engelhardt, Monika (Universitätsklinikum Freiburg) ;
Jenner, Matthew (University Hospital Southampton NHS Foundation Trust (Regne Unit)) ;
Corso, Alessandro (Hospital of Legnano) ;
Dürig, Jan (University Hospital Essen (Alemanya)) ;
Pavic, Michel (Centre Hospitalier Universitaire De Sherbrooke) ;
Salomo, Morten (Copenhagen University Hospital) ;
Beksac, Meral (Ankara University) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lindsay, Jindriska (East Kent Hospitals University NHS Foundation Trust) ;
Liberati, Anna Marina (University of Perugia) ;
Galli, Monica (Ospedale Papa Giovanni XXIII. U.O. di Ematologia) ;
Robak, Pawel (Medical University of Lodz) ;
Larocca, Alessandra (A.O.U. Citta della Salute e della Scienza di Torino) ;
Yagci, Munci (Gazi University Medical Faculty) ;
Vural, Filiz (Ege University) ;
Kanate, Abraham (West Virginia University) ;
Jiang, Ruiyun (Bristol Myers Squibb) ;
Grote, Lara (Bristol Myers Squibb) ;
Peluso, Teresa (Celgene International Sàrl. a Bristol-Myers Squibb Company) ;
Dimopoulos, Meletios (National and Kapodistrian University of Athens)
Objective: We evaluated the efficacy and safety of pomalidomide, bortezomib, and dexamethasone (PVd) vs bortezomib and dexamethasone (Vd) by age, renal function, and high-risk cytogenetic abnormalities in lenalidomide-pretreated patients with multiple myeloma at first relapse. [...]
2022 -  10.1111/ejh.13706
European Journal of Haematology, Vol. 108 Núm. 1 (january 2022) , p. 73-83
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12 p, 1.0 MB |
Guiding the global evolution of cytogenetic testing for hematologic malignancies
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Akkari, Yassmine M.N. (Departments of Cytogenetics and Molecular Pathology. Legacy Health (Estats Units d'Amèrica)) ;
Baughn, Linda B. (Mayo Clinic) ;
Dubuc, Adrian M. (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Smith, Adam C. (University of Toronto) ;
Mallo, Maria del Mar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Dal Cin, Paola (Brigham and Women's Hospital (Boston, Estats Units d'Amèrica)) ;
Diez-Campelo, María (Instituto de Investigación Biomédica de Salamanca) ;
Gallego, Marta S. (Italian Hospital) ;
Granada, Isabel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Haase, Detlef (University Medical Center Göttingen) ;
Schlegelberger, Brigitte (Department of Human Genetics. Hannover Medical School) ;
Slavutsky, Irma (Institute of Experimental Medicine) ;
Mecucci, Cristina (Hematology University of Perugia) ;
Levine, Ross L. (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica)) ;
Hasserjian, Robert P. (Massachusetts General Hospital (Boston)) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Levy, Brynn (Columbia University Medical Center) ;
Xu, Xinjie (Mayo Clinic) ;
Universitat Autònoma de Barcelona
2022 - 10.1182/blood.2021014309
Blood, Vol. 139 Núm. 15 (14 2022) , p. 2273-2284
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38 p, 835.8 KB |
Comparison of X-ray dose-response curves obtained by chromosome painting using conventional and PAINT nomenclatures
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Barquinero, Joan Francesc (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Cigarrán Valea, Sergio (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Caballín, M. R. (María Rosa) (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Braselmann, H. (GSF, National Research Center for Environment and Health, Institute of Radiobiology) ;
Ribas, Montserrat (Institut d'Investigació Biomèdica Sant Pau) ;
Egozcue, Josep 1940-2006 (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Barrios, Leonardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Purpose: The compare the suitability of PAINT and conventional nomenclature systems for the construction of chromosome aberration dose- effect curves for X-rays using FISH techniques, and to compare these curves with those based on solid-stained dicentrics analysed in first division metaphases by the FPG technique. [...]
1999 - 10.1080/095530099139160
International Journal of Radiation Biology, Vol. 75 Núm. 12 (1999) , p. 1557-1566
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24 p, 305.0 KB |
Analysis of γ-rays induced chromosome aberrations : A fingerprint evaluation with a combination of pan-centromeric and pan-telomeric probes
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Benkhaled, L. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Barrios, Leonardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Mestres, M. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Caballín, M. R. (María Rosa) (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Ribas, M. (Institut d'Investigació Biomèdica Sant Pau) ;
Barquinero, Joan Francesc (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
Purpose: To evaluate the types of induced chromosome aberrations after the exposure of peripheral blood to γ-rays by the simultaneous detection of all centromeres and telomeres; and to analyse the suitability of different radiation fingerprints for the assessment of radiation quality in cases of recent exposures. [...]
2006 - 10.1080/09553000600979092
International Journal of Radiation Biology, Vol. 82, Issue 12 (2006) , p. 869-875
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13 p, 2.2 MB |
Both Epimutations and Chromosome Aberrations Affect Multiple Imprinted Loci in Aggressive Wilms Tumors
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Pignata, Laura (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso') ;
Palumbo, Orazio (Fondazione IRCCS "Casa Sollievo della Sofferenza") ;
Cerrato, Flavia (University of Campania 'Luigi Vanvitelli') ;
Acurzio, Basilia (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso') ;
De Álava, Enrique (Universidad de Sevilla) ;
Roma, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gallego, Soledad (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Català-Mora, Jaume (Hospital Sant Joan de Déu (Manresa)) ;
Carella, Massimo (Fondazione IRCCS "Casa Sollievo Della Sofferenza") ;
Riccio, Andrea (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso') ;
Verde, Gaetano (Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso') ;
Universitat Autònoma de Barcelona
About 7% of all children's malignancies are represented by the embryonal renal cancer Wilms tumor (WT). Since methylation imprinting alterations at multiple loci dictated by chromosome copy-number variations have been recently demonstrated in adult cancers, we investigated the presence of similar alterations in pediatric malignancies. [...]
2020 - 10.3390/cancers12113411
Cancers, Vol. 12 (november 2020)
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13 p, 4.7 MB |
Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis
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Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rogers, R. B. (Department of Medicine. University of Cambridge. Cambridge Biomedical Campus) ;
Roy, A. (Department of Paediatrics. University of Oxford) ;
Schneider, P. (Princess Maxima Center for Pediatric Oncology) ;
Bardini, Michela (Università degli Studi di Milano-Bicocca) ;
Ballerini, Paola (Pediatric Hematology. A. Trousseau Hospital) ;
Cazzaniga, Giovanni (Centro Ricerca Tettamanti. Department of Pediatrics. University of Milano Bicocca. Fondazione MBBM) ;
Moreno, T. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Revilla, C. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Gut, Marta (Universitat Pompeu Fabra) ;
Valsecchi, M. G. (Interfant Trial Data Center. University of Milano-Bicocca) ;
Roberts, I. (MRC Molecular Haematology Unit. MRC Weatherall Institute of Molecular Medicine. University of Oxford) ;
Pieters, R. (Princess Maxima Center for Pediatric Oncology) ;
De Lorenzo, P. (Interfant Trial Data Center. University of Milano-Bicocca) ;
Varela, Ignacio (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Stam, R. W. (Princess Maxima Center for Pediatric Oncology) ;
Universitat Autònoma de Barcelona
Bcell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1 (MLL-AF4) infant B-cell acute lymphoblastic leukemia remains difficult to model, and the pathogenic contribution in cancer of the reciprocal fusions resulting from derivative translocated-chromosomes remains obscure. [...]
2019 - 10.3324/haematol.2018.206375
Haematologica, Vol. 104 Núm. 6 (2019) , p. 1176-1188
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9 p, 809.0 KB |
Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations
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Blanco, Gonzalo (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Puiggros, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Baliakas, Panagiotis (Uppsala University. Department of Immunology, Genetics and Pathology) ;
Athanasiadou, Anastasia (G. Papanicolaou Hospital (Thessaloniki, Greece)) ;
García-Malo, MaDolores (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Collado, Rosa (Hospital General Universitario de Valencia) ;
Xochelli, Aliki (Institute of Applied Biosciences, CERTH, Thessaloniki, Greece) ;
Rodríguez-Rivera, María (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ortega, Margarita (Hospital Universitari Vall d'Hebron) ;
Calasanz, M.J (Universidad de Navarra. Departamento de Bioquímica y Genética) ;
Luño, Elisa (Hospital Universitario Central de Asturias) ;
Vargas, MªTeresa (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Grau Cat, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez-Laperche, Carolina (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM)) ;
Valiente, Alberto (Complejo Hospitalario de Navarra) ;
Cervera, José (Hospital Universitari i Politècnic La Fe (València)) ;
Anagnostopoulos, Achilles (George Papanicolaou General Hospital (Tessalònia, Grècia)) ;
Gimeno, Eva (Hospital del Mar (Barcelona, Catalunya)) ;
Abella Monreal, Eugenia (Hospital del Mar (Barcelona, Catalunya)) ;
Stalika, Evangelia (Institute of Applied Biosciences, CERTH, Thessaloniki, Greece) ;
Hernández Rivas, Jesús María (Hospital Universitario de Salamanca) ;
Ortuño, Francisco José (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Robles, Diego (Servicio de Hematología, Hospital Txagorritxu, Vitoria, Spain) ;
Ferrer, Ana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ivars, David (Hospital General Universitario de Valencia) ;
González, Marcos (Hospital Universitario de Salamanca. Centro de Investigación del Cáncer) ;
Bosch José, Francesc Xavier 1947- (Hospital Universitari Vall d'Hebron) ;
Abrisqueta, Pau (Hospital Universitari Vall d'Hebron) ;
Stamatopoulos, Kostas (Institute of Applied Biosciences, CERTH, Thessaloniki, Greece) ;
Espinet, Blanca (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53 abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p−) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53 abs. [...]
2016 - 10.18632/oncotarget.13106
Oncotarget, Vol. 7 (november 2016) , p. 80916-80924
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18 p, 142.9 KB |
Cytogenetic effects of irradiation on somatic and germ cells
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Egozcue, Josep, 1940-2006 (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Caballín, M. R. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Álvarez Arpal, Ricardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Barrios, Leonardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Genescà, Anna, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia.) ;
Miró, Rosa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ponsa Arjona, Immaculada (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tusell Padrós, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
This paper summarizes the results obtained in two of the research projects carried out in our laboratory within the radiation protection programs of the Consejo de Seguridad Nuclear and the European Union. [...]
Aquest treball resumeix el resultats obtinguts en dos dels projectes de recerca desenvolupats en el nostre laboratori dins del marc dels programes de protecció radiològica del Consejo de Seguridad Nuclear i la Unió Europea. [...]
1999
Contributions to science, Vol. 1, Núm. 1 (1999) , p. 7-24
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