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26 p, 2.2 MB |
Inherited human ezrin deficiency impairs adaptive immunity
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García-Solís, Blanca (Hospital Universitario La Paz (Madrid)) ;
Van Den Rym, Ana (Hospital Universitario La Paz (Madrid)) ;
Martinez-Martinez, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Franco-Leyva, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez-Caraballo, Jareb J. (Vanderbilt University Medical Center) ;
Markle, Janet (Vanderbilt University Medical Center) ;
Cubillos-Zapata, Carolina (Centre for Biomedical Research Network) ;
Marín, Ana V. (Centro de investigación Hospital Universitario 12 de Octubre) ;
Recio, María J. (Centro de investigación Hospital Universitario 12 de Octubre) ;
Regueiro, José R. (Centro de investigación Hospital Universitario 12 de Octubre) ;
Navarro-Zapata, Alfonso (Hospital Universitario La Paz (Madrid)) ;
Mestre-Durín, Carmen (Hospital Universitario La Paz (Madrid)) ;
Ferreras, Cristina (Hospital Universitario La Paz (Madrid)) ;
Cotázar, Carla Martín (Hospital Universitario La Paz (Madrid)) ;
Mena, Roció (Hospital Universitario La Paz (Madrid)) ;
de la Calle-Fabregat, Carlos (Institut d'Investigació contra la Leucèmia Josep Carreras) ;
López-Lera, Alberto (Hospital Universitario La Paz (Madrid)) ;
Arquero, Miguel Fernández (Hospital Clínico San Carlos) ;
Pérez-Martínez, Antonio (Hospital Universitario La Paz (Madrid)) ;
López-Collazo, Eduardo (Hospital Universitario La Paz (Madrid)) ;
Sánchez-Ramón, Silvia (Hospital Clínico San Carlos) ;
Casanova, Jean-Laurent (Howard Hughes Medical Institute) ;
Martínez-Barricarte, Rubén (Vanderbilt University Medical Center) ;
de la Calle-Martín, Oscar (Institut d'Investigació Biomèdica Sant Pau) ;
de Diego, Rebeca Pérez (Hospital Universitario La Paz (Madrid)) ;
Universitat Autònoma de Barcelona
Inborn errors of immunity (IEI) are a group of monogenic diseases that confer susceptibility to infection, autoimmunity, and cancer. Despite the life-threatening consequences of some IEI, their genetic cause remains unknown in many patients. [...]
2023 -  10.1016/j.jaci.2023.05.022
The Journal of Allergy and Clinical Immunology, Vol. 152 (june 2023) , p. 997-1009.e11
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8 p, 890.2 KB |
End-of-Life Narratives of Patients who Request Medical Assistance in Dying : A Qualitative Study Protocol
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Vallès-Poch, Mar (Universidad de Granada. Departamento de Filosofía) ;
Parra Jounou, Iris, 1989- (Universitat Autònoma de Barcelona. Departament de Filosofia) ;
Ortega-Lozano, Ramón (Universidad Pontificia Comillas. Departamento de Ciencias de la Salud) ;
Delgado, Janet (Universidad de Granada. Departamento de Filosofía) ;
Martínez-López, María Victoria (Universidad de Granada. Departamento de Filosofía) ;
Sánchez Garrido, Silvia M. (Sistema Sanitario Público de Andalucía) ;
Tamayo-Velázquez, Maria Isabel (Escuela Andaluza de Salud Publica) ;
Triviño Caballero, Rosana (Universidad Complutense de Madrid. Facultad de Medicina) ;
Rodríguez-Arias, David (Universitat Autònoma de Barcelona)
Many groups (healthcare professionals, lawyers, philosophers, non-governmental organisations, bioethics committees, journalists, religious groups, etc. ) participate in the bioethical debate about medical assistance in dying (MAiD). [...]
SAGE Publications Inc., 2023 - 10.1177/16094069231202196
International Journal of Qualitative Methods, September 14 (2023)
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4.
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15 p, 2.7 MB |
Biomarker Profiles Associated with COVID-19 Severity and Mortality
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Sánchez-Díez, Silvia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Gómez-Ollés, Carlos (Hospital Universitari Vall d'Hebron) ;
Cruz, María Jesús (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
de Homdedeu, Miquel (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Espejo, David (Hospital Universitari Vall d'Hebron) ;
Ferrer Sancho, Jaume 1958- (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Roca, Oriol (Hospital Universitari Vall d'Hebron) ;
Pacheco, Andrés (Hospital Universitari Vall d'Hebron) ;
Muñoz Gall, Xavier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Introduction: The aim of this study was to analyze biomarkers that might predict the severity and progression of the SARS-CoV-2 infection, both in the acute phase and after recovery. Methods: Unvaccinated patients infected with the original strain of COVID-19 requiring ward (Group 1, n = 48) or ICU (Group 2, n = 41) admission were included. [...]
2023 - 10.3390/cimb45030128
Current Issues in Molecular Biology, Vol. 45, Issue 3 (March 2023) , p. 1998-2012
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5.
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14 p, 3.0 MB |
Immunopathological Mechanisms of Bird-Related Hypersensitivity Pneumonitis
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Sánchez-Díez, Silvia (Hospital Universitari Vall d'Hebron) ;
Cruz, María Jesús (Hospital Universitari Vall d'Hebron) ;
de Homdedeu, Miquel (Hospital Universitari Vall d'Hebron) ;
Ojanguren, Iñigo (Hospital Universitari Vall d'Hebron) ;
Romero-Mesones, Christian (Hospital Universitari Vall d'Hebron) ;
Sansano, Irene (Hospital Universitari Vall d'Hebron) ;
Muñoz Gall, Xavier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Bird-related hypersensitivity pneumonitis (BRHP) is an interstitial lung disease induced by avian proteins. The immunopathological pathways involved in the disease are still unknown. This study assesses the cellular immune response and the cytokine pattern in a mouse model of BRHP. [...]
2023 - 10.3390/ijms24032884
International journal of molecular sciences, Vol. 24 (february 2023)
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6.
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3.4 MB |
Pathophysiological mechanisms involved in acute and chronic hypersensitivity pneumonitis2
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Sánchez Díez, Silvia ;
Cruz Carmona, María Jesús, dir. ;
Muñoz Gall, Xavier, dir. ;
Ferrer Sancho, Jaume, 1958-, dir.
La pneumonitis per hipersensibilitat (PH) és una malaltia pulmonar intersticial caracteritzada per una inflamació broncoalveolar generalment causada per la inhalació de proteïnes aviàries i fúngiques. [...]
La neumonitis por hipersensibilidad (NH) es una enfermedad pulmonar intersticial caracterizada por una inflamación broncoalveolar generalmente causada por la inhalación de proteínas aviares y fúngicas. [...]
Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) characterized by a bronchoalveolar inflammation usually caused by the inhalation of avian and fungal proteins. The immunopathological pathways involved in the disease after antigen exposure are still unknown. [...]
2022
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24 p, 2.1 MB |
Uso de realidad virtual en Geometría para el desarrollo de habilidades espaciales
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Moral-Sánchez, Silvia Natividad (Universidad de Málaga) ;
Sánchez-Compaña, María Teresa (Universidad de Málaga) ;
Romero Albaladejo, Isabel María (Universidad de Almería)
En el siglo xxi, surge la necesidad de un cambio en el paradigma educativo, siendo las TIC un medio vehicular que puede hacer posible esta consecución. En este artículo se exponen un conjunto de actividades sobre poliedros en 3. [...]
In the 21st century, there is a need for a change in the educational paradigm, and ICT can serve as a means to make it possible. This article presents a set of activities on polyhedra in 3rd of ESO (students aged between 14 and 16) to promote the acquisition and improvement of spatial skills. [...]
2023 - 10.5565/rev/ensciencias.5442
Enseñanza de las ciencias, Vol. 41 Núm. 1 (2023) , p. 125-147 (Innovaciones Didácticas)
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19 p, 807.7 KB |
Producción de materiales educativos para la enseñanza del mapuzugun : aproximación desde la experiencia y perspectivas de las y los educadores
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Castillo Sánchez, Silvia (University of Los Lagos) ;
Mayo González, Simona (Universidad Católica Silva Henríquez) ;
Soto Cárcamo, Jorge (Diego Portales University)
Se analiza la producción de materiales didácticos para la enseñanza del mapuzugun en contextos formales y no formales, desde la experiencia y perspectivas de enseñantes/educadores. Se realizaron entrevistas semiestructuradas, siguiendo la práctica del nütram (expresión del arte verbal mapuche), a diez educadores/as mayoritariamente mapuche. [...]
S'analitza la producció de materials didàctics per a l'ensenyament del mapuzugun en contextos formals i no formals, des de l'experiència i perspectives d'ensenyants/educadors. Es van realitzar entrevistes semiestructurades, seguint la pràctica del nütram (expressió de l'art verbal maputxe), a deu educadors majoritàriament maputxe. [...]
Our study focuses on Mapuzugun educational materials' production-analyzed from teachers/educators' experience in formal and non-formal contexts. We applied semi-structured interviews to ten educators, most of Mapuche heritage, following the practice of nütram (Mapuche verbal art). [...]
La production de matériel pour l'enseignement du mapuzugun dans des contextes formels et non formels est analysée à partir de l'expérience et des perspectives des enseignants/éducateurs. Des entretiens semi-directifs ont été menés selon la pratique du nütram (expression de l'art verbal mapuche) auprès d'une dizaine d'éducateurs, majoritairement mapuche. [...]
2022 - 10.5565/rev/jtl3.916
Bellaterra journal of teaching and learning language and literature, Vol. 15 Núm. 1 (2022) , p. e916 (Articles)
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14 p, 3.8 MB |
dIvergEnt : How IgE Axis Contributes to the Continuum of Allergic Asthma and Anti-IgE Therapies
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Palomares, Óscar (Universidad Complutense de Madrid) ;
Sánchez-Ramón, Silvia (Universidad Complutense de Madrid. Departamento de Microbiología y Parasitología) ;
Dávila, Ignacio (Instituto de Investigación Biomédica de Salamanca) ;
Prieto, Luis (Hospital Universitari Doctor Peset (València)) ;
Pérez de Llano, Luis (Hospital Universitario Lucus Augusti (Lugo)) ;
Lleonart, Marta (Novartis Farmacéutica (Espanya)) ;
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Nieto Garcíá, Antonio (Hospital Universitari i Politècnic La Fe (València)) ;
Universitat Autònoma de Barcelona
Asthma is an airway disease characterised by chronic inflammation with intermittent or permanent symptoms including wheezing, shortness of breath, chest tightness, and cough, which vary in terms of their occurrence, frequency, and intensity. [...]
2017 - 10.3390/ijms18061328
International journal of molecular sciences, Vol. 18 (june 2017)
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10.
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15 p, 4.5 MB |
Minimum Information about T Regulatory Cells : A Step toward Reproducibility and Standardization
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Fuchs, Anke (Technische Universität Dresden, Germany) ;
Gliwiński, Mateusz (Medical University of Gdańsk, Poland) ;
Grageda, Nathali (MRC Centre for Transplantation, King's College London, Guy's Hospital) ;
Spiering, Rachel (Newcastle University) ;
Abbas, Abul K. (University of California, San Francisco) ;
Appel, Silke (University of Bergen, Norway) ;
Bacchetta, Rosa (Stanford School of Medicine, United States) ;
Battaglia, Manuela (San Raffaele Hospital, Milan) ;
Berglund, David (Uppsala University, Sweden) ;
Blazar, Bruce (University of Minnesota, United States) ;
Bluestone, Jeffrey A. (University of California, San Francisco, United States) ;
Bornhäuser, Martin (Technische Universität Dresden, Germany) ;
ten Brinke, Anja (University of Amsterdam) ;
Brusko, Todd M. (University of Florida Diabetes Institute) ;
Cools, Nathalie (University Hospital Antwerp (Bèlgica)) ;
Cuturi, Maria Cristina (Université de Nantes) ;
Geissler, Edward (University Hospital Regensburg, Germany) ;
Giannoukakis, Nick (Carnegie Mellon University, Pittsburgh, United States) ;
Gołab, Karolina (The University of Chicago, United States) ;
Hafler, David A. (Yale School of Medicine, New Haven, United States) ;
van Ham, S. Marieke (University of Amsterdam) ;
Hester, Joanna (University of Oxford) ;
Hippen, Keli (University of Minnesota, United States) ;
Di Ianni, Mauro (University of Chieti-Pescara) ;
Ilic, Natasa (University of Belgrade) ;
Isaacs, John (National Institute for Health Research Newcastle Biomedical Research Centre at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University) ;
Issa, Fadi (University of Oxford) ;
Iwaszkiewicz-Grzes, Dorota (Medical University of Gdańsk, Poland) ;
Jaeckel, Elmar (Department of Gastroenterology, Hepatology, Endocrinology, Diabetology, Transplantationsforschungszentrum, Medical School of Hannover (MHH)) ;
Joosten, Irma (Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboudumc, Netherlands) ;
Klatzmann, David (Hôpital Pitié-Salpêtrière, Paris) ;
Koenen, Hans (Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboudumc, Netherlands) ;
van Kooten, Cees (Leiden University Medical Center, Netherlands) ;
Korsgren, Olle (Gothenburg University, Sweden) ;
Kretschmer, Karsten (University Hospital and Medical Faculty Carl Gustav Carus of TU Dresden, Germany) ;
Levings, Megan (The University of British Columbia, Vancouver, Canada) ;
Marek-Trzonkowska, Natalia Maria (Medical University of Gdańsk, Poland) ;
Martinez-Llordella, Marc (King's College London) ;
Miljkovic, Djordje (University of Belgrade) ;
Mills, Kingston H. G. (Trinity College Dublin, Ireland) ;
Miranda, Joana P. (Universidade de Lisboa) ;
Piccirillo, Ciriaco A. (Research Institute of McGill University Health Centre, Montréal, Canada) ;
Putnam, Amy L. (University of California, San Francisco) ;
Ritter, Thomas (National University of Ireland) ;
Roncarolo, Maria Grazia (Division of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, ISCBRM, Stanford School of Medicine) ;
Sakaguchi, Shimon (Osaka University, Japan) ;
Sánchez-Ramón, Silvia (Hospital Clínico San Carlos (Madrid)) ;
Sawitzki, Birgit (Humboldt-Universität zu Berlin) ;
Sofronic-Milosavljevic, Ljiljana (University of Belgrade) ;
Sykes, Megan (University of California, San Francisco) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Waldmann, Herman (University of Oxford) ;
Witkowski, Piotr (The University of Chicago) ;
Wood, Kathryn J. (University of Oxford) ;
Gregori, Silvia (San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), San Raffaele Scientific Institute IRCCS) ;
Hilkens, Catharien M. U. (Newcastle University) ;
Lombardi, Giovanna (MRC Centre for Transplantation, King's College London, Guy's Hospital) ;
Lord, Phillip (School of Computing, Newcastle University) ;
Martinez-Caceres, Eva Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Trzonkowski, Piotr (Medical University of Gdańsk, Poland)
Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. [...]
2018 - 10.3389/fimmu.2017.01844
Frontiers in immunology, Vol. 8 (january 2018)
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