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9 p, 750.9 KB |
Low-symmetry topological materials for large charge-to-spin interconversion : the case of transition metal dichalcogenide monolayers
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Vila Tusell, Marc (Universitat Autònoma de Barcelona. Departament de Física) ;
Hsu, Chuang-Han (National University of Singapore. Department of Electrical and Computer Engineering) ;
Garcia, José H. (Institut Català de Nanociència i Nanotecnologia) ;
Benítez, L. Antonio (Institut Català de Nanociència i Nanotecnologia) ;
Waintal, Xavier (Université Grenoble Alpes. Commissariat à l'énergie atomique et aux énergies alternatives) ;
Valenzuela, Sergio O. (Institut Català de Nanociència i Nanotecnologia) ;
Pereira, Víctor M. (National University of Singapore. Centre for Advanced 2D Materials and Graphene Research Centre) ;
Roche, Stephan (Institut Català de Nanociència i Nanotecnologia)
The spin polarization induced by the spin Hall effect (SHE) in thin films typically points out of the plane. This is rooted on the specific symmetries of traditionally studied systems, not in a fundamental constraint. [...]
2021 -  10.1103/PhysRevResearch.3.043230
Physical Review Research, Vol. 3, issue 4 (Dec. 2021) , art. 43230
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2.
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21 p, 5.7 MB |
Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain : A New Indication for Soluble Epoxide Hydrolase Inhibitors
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Codony, Sandra (Consejo Superior de Investigaciones Científicas (Espanya)) ;
Entrena, José M. (Universidad de Granada) ;
Calvó-Tusell, Carla (Universitat de Girona) ;
Jora, Beatrice (Consejo Superior de Investigaciones Científicas (Espanya)) ;
González-Cano, Rafael (Universidad de Granada) ;
Osuna, Sílvia (Institució Catalana de Recerca i Estudis Avançats) ;
Corpas, Rubén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Morisseau, Christophe (University of California) ;
Pérez, Belén (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Barniol-Xicota, Marta (KU Leuven-University) ;
Griñán-Ferré, Christian (Universitat de Barcelona) ;
Pérez, Concepción (Consejo Superior de Investigaciones Científicas (Espanya)) ;
Rodríguez-Franco, María Isabel (Consejo Superior de Investigaciones Científicas (Espanya)) ;
Martínez, Antón L. (Universidade de Santiago de Compostela) ;
Loza, M. Isabel (Universidade de Santiago de Compostela) ;
Pallàs, Mercè (Universitat de Barcelona) ;
Verhelst, Steven H. L. (AG Chemical Proteomics) ;
Sanfeliu i Pujol, Coral (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Feixas, Ferran (Universitat de Girona) ;
Hammock, Bruce D. (University of California) ;
Brea, José (Universidade de Santiago de Compostela) ;
Cobos, Enrique J. (Universidad de Granada) ;
Vázquez, Santiago (Consejo Superior de Investigaciones Científicas (Espanya))
The soluble epoxide hydrolase (sEH) has been suggested as a pharmacological target for the treatment of several diseases, including pain-related disorders. Herein, we report further medicinal chemistry around new benzohomoadamantane-based sEH inhibitors (sEHI) in order to improve the drug metabolism and pharmacokinetics properties of a previous hit. [...]
2022 - 10.1021/acs.jmedchem.2c00515
Journal of Medicinal Chemistry, Vol. 65 (october 2022) , p. 13660-13680
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30 p, 263.4 KB |
Telomere dysfunction : A new player in radiation sensitivity
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Genescà, Anna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Martín Flix, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Latre, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Soler, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pampalona Sala, Judit (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tusell Padrós, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Human individuals often exhibit important differences in their sensitivity to ionising radiation. Extensive literature links radiation sensitivity with impaired DNA repair which is due to a lack of correct functioning in many proteins involved in DNA-repair pathways and/or in DNA-damage checkpoint responses. [...]
2006 - 10.1002/bies.20501
BioEssays, Vol. 28, Issue 12 (December 2006) , p. 1172-1180
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25 p, 318.6 KB |
ATM and DNA-PKcs make a complementary couple in DNA double strand break repair
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Martín Flix, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Terradas, Mariona (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Tusell Padrós, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Genescà, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The interplay between ATM and DNA-PKcs kinases during double strand breaks (DSBs) resolution is still a matter of debate. ATM and DNA-PKcs participate differently in the DNA damage response pathway (DDR), but important common aspects are indeed found: both of them are activated when faced with DSBs, they share common targets in the DDR and the absence of either kinase results in faulty DSB repair. [...]
2012 - 10.1016/j.mrrev.2011.12.006
Mutation Research - Reviews in Mutation Research, Vol. 751, Issue 1 (July-September 2012) , p. 29-35
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39 p, 4.0 MB |
Breaks invisible to the DNA damage response machinery accumulate in ATM-deficient cells
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Martín Flix, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Terradas, Mariona (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Iliakis, George (University Duisburg-Essen Medical School) ;
Tusell Padrós, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Genescà, Anna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
After irradiation, ATM defective cells accumulate unrepaired double strand breaks (DSBs) for several cell divisions. At the chromosome level, unresolved DSBs appear as chromosome breaks that can be efficiently scored by using telomeric and mFISH probes. [...]
2009 - 10.1002/gcc.20679
Genes Chromosomes and Cancer, Vol. 48, Issue 9 (September 2009) , p. 745-759
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10 p, 4.1 MB |
Increased Mammogram-Induced DNA Damage in Mammary Epithelial Cells Aged In Vitro
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Hernández, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Terradas, Mariona (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martín Flix, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Feijoo, Purificación (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Soler, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tusell Padrós, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Genescà, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Concerned about the risks of mammography screening in the adult population, we analyzed the ability of human mammary epithelial cells to cope with mammogram-induced DNA damage. Our study shows that an X-ray dose of 20 mGy, which is the standard dose received by the breast surface per two-view mammogram X-ray exploration, induces increased frequencies of DNA double-strand breaks to in vitro aged-but not to young-human mammary epithelial cells. [...]
2013 - 10.1371/journal.pone.0063052
PloS one, Vol. 8, Issue 5 (May 2013) , art. e63052
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17 p, 3.4 MB |
Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase
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Pampalona Sala, Judit (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Roscioli, Emanuele (Virginia Polytechnic Institute and State University. Department of Biological Sciences) ;
Silkworth, William T. (Virginia Polytechnic Institute and State University. Department of Biological Sciences) ;
Bowden, Brent (Virginia Polytechnic Institute and State University. Department of Biological Sciences) ;
Genescà, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tusell Padrós, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cimini, Daniela (Virginia Polytechnic Institute and State University. Department of Biological Sciences)
Accurate chromosome segregation during cell division is essential to maintain genome stability, and chromosome segregation errors are causally linked to genetic disorders and cancer. An anaphase chromosome bridge is a particular chromosome segregation error observed in cells that enter mitosis with fused chromosomes/sister chromatids. [...]
2016 - 10.1371/journal.pone.0147420
PloS one, Vol. 11, Issue 1 (January 2016) , art. e0147420
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20 p, 8.2 MB |
Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16 INK4a -deficient epithelial cells
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Bernal Martínez, Aina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Moltó Abad, Marc (Hospital Universitari Vall d'Hebron) ;
Domínguez, Daniel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Tusell Padrós, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Telomere dysfunction drives chromosome instability through endless breakage-fusion-bridge (BFB) cycles that promote the formation of highly rearranged genomes. However, reactivation of telomerase or ALT-pathway is required for genome stabilisation and full malignant transformation. [...]
2018 - 10.18632/oncotarget.25502
Oncotarget, Vol. 9 (june 2018) , p. 27151-27170
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10.
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9 p, 1.8 MB |
Magnetic proximity in a van der Waals heterostructure of magnetic insulator and graphene
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Karpiak, Bogdan (Chalmers University of Technology) ;
Cummings, Aron (Institut Català de Nanociència i Nanotecnologia) ;
Zollner, Klaus (University of Regensburg) ;
Vila Tusell, Marc (Universitat Autònoma de Barcelona. Departament de Física) ;
Khokhriakov, Dmitrii (Chalmers University of Technology) ;
Hoque, Anamul Md (Chalmers University of Technology) ;
Dankert, André (Chalmers University of Technology) ;
Svedlindh, Peter (Uppsala University) ;
Fabian, Jaroslav (University of Regensburg) ;
Roche, Stephan (Institut Català de Nanociència i Nanotecnologia) ;
Dash, Saroj P. (Chalmers University of Technology)
Engineering 2D material heterostructures by combining the best of different materials in one ultimate unit can offer a plethora of opportunities in condensed matter physics. Here, in the van der Waals heterostructures of the ferromagnetic insulator CrGeTe and graphene, our observations indicate an out-of-plane proximity-induced ferromagnetic exchange interaction in graphene. [...]
2019 - 10.1088/2053-1583/ab5915
2D Materials, Vol. 7, Núm. 1 (December 2019) , art. 15026
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