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14 p, 1.3 MB |
Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy
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González, Carolina (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Roche Diagnostics SL) ;
Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Godoy, Cristina (Hospital Universitari Vall d'Hebron) ;
Sopena, Sara (Hospital Universitari Vall d'Hebron) ;
Rando-Segura, Ariadna (Hospital Universitari Vall d'Hebron) ;
Yll, Marçal (Hospital Universitari Vall d'Hebron) ;
Lopez Martinez, Rosa (Hospital Universitari Vall d'Hebron) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Esteban Mur) (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Buti, Maria (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Rodríguez Frías, Francisco (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
To detect hyper-conserved regions in the hepatitis B virus (HBV) X gene (HBX) 5' region that could be candidates for gene therapy. The study included 27 chronic hepatitis B treatment-naive patients in various clinical stages (from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeAg-negative and HBeAg-positive), and infected with HBV genotypes A-F and H. [...]
2018 -  10.3748/wjg.v24.i19.2095
World Journal of Gastroenterology, Vol. 24 (may 2018) , p. 2095-2107
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14 p, 1.3 MB |
Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population
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Casillas, Rosario (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Belmonte, Irene (Hospital Universitari Vall d'Hebron) ;
Cortese, Maria Francesca (Hospital Universitari Vall d'Hebron) ;
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Riveiro Barciela, Mar ;
López, Rosa Maria (Hospital Universitari Vall d'Hebron) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Esteban, Rafael (Esteban Mur) ;
Buti, Maria ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
To determine the variability/conservation of the domain of hepatitis B virus (HBV) preS1 region that interacts with sodium-taurocholate cotransporting polypeptide (hereafter, NTCP-interacting domain) and the prevalence of the rs2296651 polymorphism (S267F, NTCP variant) in a Spanish population. [...]
2018 - 10.3748/wjg.v24.i6.680
World Journal of Gastroenterology, Vol. 24 (february 2018) , p. 680-692
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38.
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6 p, 168.2 KB |
Assessment of a Novel Automatic Real-Time PCR Assay on the Cobas 4800 Analyzer as a Screening Platform for Hepatitis C Virus Genotyping in Clinical Practice : Comparison with Massive Sequencing
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Nieto, Leonardo (Hospital Universitari Vall d'Hebron) ;
Quer, Josep 1963- (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Ripa, Alicia (Hospital Universitari Vall d'Hebron) ;
Tabernero, David (Hospital Universitari Vall d'Hebron) ;
González, Carolina (Hospital Universitari Vall d'Hebron) ;
Gregori i Font, Josep (Hospital Universitari Vall d'Hebron) ;
Vila, Marta (Hospital Universitari Vall d'Hebron) ;
Asensio, Miriam (Hospital Universitari Vall d'Hebron) ;
Garcia-Cehic, D. (Hospital Universitari Vall d'Hebron) ;
Ruiz, Gerardo (Hospital Universitari Vall d'Hebron) ;
Chen, Qian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ordeig, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Llorens, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Saez, Montserrat (Hospital Universitari Vall d'Hebron) ;
Esteban Mur, Juan Ignacio (Hospital Universitari Vall d'Hebron) ;
Esteban, Rafael (Esteban Mur) (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Pumarola Suñé, Tomàs (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez Frías, Francisco (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The unequivocal identification of hepatitis C virus (HCV) subtypes 1a/1b and genotypes 2 to 6 is required for optimizing the effectiveness of interferon-free, direct-acting antiviral therapies. We compared the performance of a new real-time HCV genotyping assay used on the Cobas 4800 system (C4800) with that of high-resolution HCV subtyping (HRCS). [...]
2017 - 10.1128/JCM.01960-16
Journal of Clinical Microbiology, Vol. 55 (january 2017) , p. 504-509
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40.
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220 p, 10.9 MB |
Complejidad de la cuasiespecie del virus de la hepatitis B en la región X/preCore: asociación con la evolución de la infección con y sin tratamiento antiviral
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Caballero, Andrea ;
Rodríguez Frías, Francisco, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Buti, Maria, dir. ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
El Virus de la hepatitis B (VHB) tiene una tasa de mutación de 3,2×10-5 - 7,9×10-5 nucleótidos sustituidos/ciclo replicativo, esto se debe a que este ciclo consta de un paso de retrotranscripción llevado a cabo por una transcriptasa reversa que carece de actividad correctora de errores exonucleasa 3'-5'. [...]
Hepatitis B Virus (HBV) shows a high mutation rate (3. 2 × 10-5 - 7. 9 × 10-5 nucleotide substitutions/replicative cycle), due to its unique life cycle which requires an error-prone reverse transcriptase for replication. [...]
[Barcelona] : Universitat Autònoma de Barcelona, 2016
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7 p, 191.5 KB |
Paracetamol in therapeutic dosages and acute liver injury : causality assessment in a prospective case series
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Sabaté, Mònica (Hospital Universitari Vall d'Hebron) ;
Ibáñez, Luisa (Hospital Universitari Vall d'Hebron) ;
Pérez, Eulàlia (Hospital Universitari Vall d'Hebron) ;
Vidal Guitart, Xavier (Hospital Universitari Vall d'Hebron) ;
Buti, Maria (Hospital Universitari Vall d'Hebron) ;
Xiol, Xavier (Hospital Universitari de Bellvitge) ;
Mas, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Guarner, Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Forné, Montserrat (Hospital de Mútua (Terrassa, Catalunya)) ;
Solà Lamoglia, Ricard (Hospital del Mar (Barcelona, Catalunya)) ;
Castellote, José (Hospital Universitari de Bellvitge) ;
Rigau, Joaquim (Hospital General de Granollers) ;
Laporte Rosselló, Joan-Ramón (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Background: Acute liver injury (ALI) induced by paracetamol overdose is a well known cause of emergency hospital admission and death. However, there is debate regarding the risk of ALI after therapeutic dosages of the drug. [...]
Our results indicate that paracetamol in therapeutic dosages may be considered in the causality assessment in non-alcoholic patients with liver injury, even if the estimated incidence of ALI related to paracetamol appears to be low.
2011 - 10.1186/1471-230X-11-80
BMC Gastroenterology, Vol. 11, N. 80 (July 2011) , p. 1-7
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