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1.
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10 p, 2.6 MB |
Epigenetic Profiling and Response to CD19 Chimeric Antigen Receptor T-Cell Therapy in B-Cell Malignancies
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villanueva, Lorea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-Navarro, Europa Azucena (Department of Immunology. Hospital Clinic) ;
Juan, Manuel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Urbano-Ispizua, Álvaro (Department of Hematology. University of Barcelona) ;
Delgado, Julia (Centro de Investigación Biomedica en Red de Cancer) ;
Ortiz-Maldonado, Valetín (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Del Bufalo, Francesca (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Locatelli, Franco (Sapienza University of Rome) ;
Quintarelli, Concetta (Department of Clinical Medicine and Surgery. University of Naples Federico II) ;
Sinibaldi, Matilde (Department of Paediatric Haematology and Oncology. Bambino Gesù Children's Hospital) ;
Soler, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Castro De Moura, Manuel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ferrer, Gerardo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Urdinguio, Rocío G. (Universidad de Oviedo) ;
Fernandez, A.F. (Universidad de Oviedo) ;
Fraga, Mario F. (Universidad de Oviedo) ;
Bar, Diana (The Edmond and Lily Safra Children's Hospital) ;
Meir, Agustín (The Edmond and Lily Safra Children's Hospital) ;
Itzhaki, Orit (Ella Lemelbaum Institute for Immuno Oncology) ;
Besser, MichalJ. (Tel Aviv University) ;
Avigdor, Abraham (Sheba Medical Center) ;
Jacoby, Elad (Tel Aviv University) ;
Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques)
Background: Chimeric antigen receptor (CAR) T cells directed against CD19 (CART19) are effective in B-cell malignancies, but little is known about the molecular factors predicting clinical outcome of CART19 therapy. [...]
2022 -  10.1093/jnci/djab194
Journal of the National Cancer Institute, Vol. 114 Núm. 3 (january 2022) , p. 436-445
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2.
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27 p, 8.1 MB |
Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
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Liang, Wen-Wei (Washington University in St. Louis) ;
Lu, Rita Jui-Hsien Lu (Washington University in St. Louis) ;
Jayasinghe, Reyka G. (Washington University in St. Louis) ;
Foltz, Steven M. (Washington University in St. Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Geffen, Yifat (Massachusetts General Hospital (Boston)) ;
Wendl, Michael C. (Department of Mathematics. Washington University in St. Louis) ;
Lazcano, Rossana (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ;
Kolodziejczak, Iga (Medical University of Warsaw) ;
Song, Yizhe (Washington University in St. Louis) ;
Govindan, Akshay (Washington University in St. Louis) ;
Demicco, Elisabeth G. (University of Toronto) ;
Li, Xiang (Washington University in St. Louis) ;
Li, Yize (Washington University in St. Louis) ;
Sethuraman, Sunantha (Washington University in St. Louis) ;
Payne, Samuel H. (Department of Biology. Brigham Young University) ;
Fenyö, David (Department of Biochemistry and Molecular Pharmacology. NYU Grossman School of Medicine) ;
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research. National Cancer Institute) ;
Wiznerowicz, Maciej (Poznań University of Medical Sciences) ;
Shen, Hui (Van Andel Research Institute) ;
Mani, D.R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Rodland, Karin D. (Developmental. and Cancer Biology. Oregon Health & Science University) ;
Lazar, Alexander J. (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ;
Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ;
Ding, Li (Washington University in St. Louis) ;
Universitat Autònoma de Barcelona
DNA methylation plays a critical role in establishing and maintaining cellular identity. However, it is frequently dysregulated during tumor development and is closely intertwined with other genetic alterations. [...]
2023 - 10.1016/j.ccell.2023.07.013
Cancer Cell, Vol. 41 Núm. 9 (november 2023) , p. 1567-1585.e7
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3.
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17 p, 1.3 MB |
Altered methylation pattern in EXOC4 is associated with stroke outcome : an epigenome-wide association study
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Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano Tárraga, Carolina (NeuroGenomics and Informatics. Washington University School of Medicine) ;
Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Llucià-Carol, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Lledós, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Esteller, M (Institució Catalana de Recerca i Estudis Avançats) ;
Castro de Moura, Manuel (Programa de Epigenética y Biología del Cáncer (PEBC)) ;
Montaner, Joan (Instituto de Biomedicina de Sevilla) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martí-Fàbregas, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Krupinski, Jerzy (Centre for Bioscience. School of HealthCare Science. Manchester Metropolitan University) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Jimenez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background and purpose: The neurological course after stroke is highly variable and is determined by demographic, clinical and genetic factors. However, other heritable factors such as epigenetic DNA methylation could play a role in neurological changes after stroke. [...]
2022 - 10.1186/s13148-022-01340-5
Clinical Epigenetics, Vol. 14 Núm. 1 (december 2022) , p. 124
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4.
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18 p, 9.8 MB |
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses
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Rodríguez-Ubreva, J. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Arutyunyan, A. (University of Cambridge) ;
Bonder, M.J. (German Cancer Research Center) ;
Del Pino-Molina, L. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Clark, S.J. (Babraham Institute) ;
de la Calle-Fabregat, Carlos (Institut d'Investigació Biomèdica de Bellvitge) ;
Garcia-Alonso, L. (CeWellcome Sanger Institute) ;
Handfield, L.F. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Krueger, F. (Babraham Institute) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Cortez, V.C. (Institut d'Investigació Biomèdica de Bellvitge) ;
Polanski, K. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Mamanova, L. (Wellcome Trust Sanger Institute (Regne Unit)) ;
van Dongen, S. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Kiselev, V.Y. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Martínez-Saavedra, M.T. (Hospital Universitario de Gran Canaria Dr. Negrín) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Martín, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Warnatz, K. (University of Freiburg) ;
López-Granados, E. (Instituto de Investigación Sanitaria del Hospital Universitario La Paz) ;
Rodríguez-Gallego, C. (University Fernando Pessoa) ;
Stegle, O. (Wellcome Trust Sanger Institute (Regne Unit)) ;
Kelsey, G. (Babraham Institute) ;
Vento Tormo, Roser (University of Cambridge) ;
Ballestar, Esteban (East China Normal University) ;
Universitat Autònoma de Barcelona
Common variable immunodeficiency (CVID), the most prevalent symptomatic primary immunodeficiency, displays impaired terminal B-cell differentiation and defective antibody responses. Incomplete genetic penetrance and ample phenotypic expressivity in CVID suggest the participation of additional pathogenic mechanisms. [...]
2022 - 10.1038/s41467-022-29450-x
Nature communications, Vol. 13 Núm. 1 (december 2022) , p. 1779
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5.
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7 p, 1.1 MB |
Accelerated biological aging in COVID-19 patients
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Cao, Xue (Department of Colorectal Surgery. The Sixth Affiliated Hospital. Sun Yat-sen University) ;
Li, Wenjuan (Department of Pulmonary and Critical Care Medicine. The Third Affiliated Hospital. Sun Yat-sen University) ;
Wang, Ting (Research & Development. Thermo Fisher Scientific Inc.) ;
Ran, Dongzhi (University of Arizona. Department of Pharmacology) ;
Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Planas-Serra, Laura (Institut d'Investigació Biomèdica de Bellvitge) ;
Pujol, Aurora 1968- (Institut d'Investigació Biomèdica de Bellvitge) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Wang, Xiaolin (Guangdong Institute of Gastroenterology. Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease. The Sixth Affiliated Hospital. Sun Yat-sen University) ;
Yu, Huichuan (Department of Colorectal Surgery. The Sixth Affiliated Hospital. Sun Yat-sen University)
Chronological age is a risk factor for SARS-CoV-2 infection and severe COVID-19. Previous findings indicate that epigenetic age could be altered in viral infection. However, the epigenetic aging in COVID-19 has not been well studied. [...]
2022 - 10.1038/s41467-022-29801-8
Nature communications, Vol. 13 Núm. 1 (december 2022) , art. 2135
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6.
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15 p, 2.7 MB |
Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
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García Gómez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martín Sánchez, Montserrat (Universidad de Salamanca) ;
San Segundo, Laura (Universidad de Salamanca) ;
Muntión, Sandra (Universidad de Salamanca) ;
Morales, Xabier (Universidad de Navarra) ;
Ortiz de Solórzano, Carlos (Universidad de Navarra) ;
Oyarzabal, Julen (Universidad de Navarra) ;
San José Enériz, Edurne (Universidad de Navarra) ;
Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques) ;
Agirre, Xabier (Universidad de Navarra) ;
Prosper, Felipe (Universidad de Navarra) ;
Garayoa, Mercedes (Universidad de Salamanca) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. [...]
2021 - 10.1038/s41467-020-20715-x
Nature communications, Vol. 12 Núm. 1 (december 2021) , p. 421
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7.
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8 p, 659.0 KB |
Dynamic epigenetic age mosaicism in the human atherosclerotic artery
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Zaina, Silvio (University of Guanajuato) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gonçalves, Isabel (Lund University) ;
Lund, Gertrud (CINVESTAV Irapuato Unit)
Accelerated epigenetic ageing, a promising marker of disease risk, has been detected in peripheral blood cells of atherosclerotic patients, but evidence in the vascular wall is lacking. Understanding the trends of epigenetic ageing in the atheroma may provide insights into mechanisms of atherogenesis or identify targets for molecular therapy. [...]
2022 - 10.1371/journal.pone.0269501
PloS one, Vol. 17 Núm. 6 June (june 2022) , p. e0269501
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8.
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19 p, 964.7 KB |
DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness
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Carrier, Arnaud (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Desjobert, Cécile (Unité de Service et de Recherche) ;
Ponger, Loic (Sorbone University) ;
Lamant, Laurence (Université Toulouse III Paul Sabatier) ;
Bustos, Matias (Saint John's Cancer Institute) ;
Torres Ferreira, Jorge (Portuguese Oncology Institute of Porto) ;
Henrique, Rui (University of Porto) ;
Jeronimo, Carmen (University of Porto) ;
Lanfrancone, Luisa (Instituto Europeo di Oncologia) ;
Delmas, Audrey (Université Toulouse III Paul Sabatier) ;
Favre, Gilles (Université Toulouse III Paul Sabatier) ;
Daunay, Antoine (Fondation Jean Dausset-CEPH) ;
Busato, Florence (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ;
Hoon, Dave S. B. (Saint John's Cancer Institute) ;
Tost, Jorg (Université Paris-Saclay. Centre National de Recherche en Génomique Humaine) ;
Etievant, Chantal (Unité de Service et de Recherche) ;
Riond, Joëlle (Université Toulouse III Paul Sabatier) ;
Arimondo, Paola Barbara (Institut Pasteur)
Aberrant DNA methylation is a well-known feature of tumours and has been associated with metastatic melanoma. However, since melanoma cells are highly heterogeneous, it has been challenging to use affected genes to predict tumour aggressiveness, metastatic evolution, and patients' outcomes. [...]
2022 - 10.7554/eLife.78587
eLife, Vol. 11 (september 2022) , p. e78587
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9.
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19 p, 5.0 MB |
Coordinated glucocorticoid receptor and MAFB action induces tolerogenesis and epigenome remodeling in dendritic cells
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Morante-Palacios, Octavio. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Micheroli, Raphael (University of Zurich) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Barbisan, Gisela (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Houtman, Miranda (University of Zurich) ;
Edalat, Sam G. (University of Zurich) ;
Frank-Bertoncelj, Mojca (University of Zurich) ;
Ospelt, Caroline (University of Zurich) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Glucocorticoids (GCs) exert potent anti-inflammatory effects in immune cells through the glucocorticoid receptor (GR). Dendritic cells (DCs), central actors for coordinating immune responses, acquire tolerogenic properties in response to GCs. [...]
2022 - 10.1093/nar/gkab1182
Nucleic acids research, Vol. 50 Núm. 1 (january 2022) , p. 108-126
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