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10 p, 1.6 MB |
Neuroprotection mediated by cystatin C-loaded extracellular vesicles
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Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ;
Sahoo, Susmita (Icahn School of Medicine at Mount Sinai) ;
Gauthier, Sebastien A. (Nathan S. Kline Institute) ;
Kim, Yohan (NYU Langone Medical Center) ;
Li, Meihua (Nathan S. Kline Institute) ;
Kumar, Asok (Nathan S. Kline Institute) ;
Pawlik, Monika (Nathan S. Kline Institute) ;
Benussi, Luisa (IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Ghidoni, Roberta (IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli) ;
Levy, Efrat (Neuroscience Institute) ;
Universitat Autònoma de Barcelona
Cystatin C (CysC) is implicated in neuroprotection and repair in the nervous system in response to diverse neurotoxic conditions. In addition to being secreted from cells in a soluble form, CysC is released by cells in association with extracellular vesicles (EVs), including exosomes. [...]
2019 -  10.1038/s41598-019-47524-7
Scientific reports, Vol. 9 Núm. 1 (31 2019) , p. 11104
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10 p, 508.1 KB |
Extracellular vesicles : where the amyloid precursor protein carboxyl-terminal fragments accumulate and amyloid-β oligomerizes
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Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ;
Kim, Y. (New York University School of Medicine) ;
Miller, C. (Nathan S. Kline Institute) ;
Pacheco-Quinto, J. (Biomedical Research Institute of New Jersey) ;
Eckman, E.A. (Biomedical Research Institute of New Jersey) ;
Levy, E. (New York University School of Medicine) ;
Universitat Autònoma de Barcelona
Pleiotropic roles are proposed for brain extracellular vesicles (EVs) in the development of Alzheimer's disease (AD). Our previous studies have suggested a beneficial role for EVs in AD, where the endosomal system in vulnerable neurons is compromised, contributing to the removal of accumulated material from neurons. [...]
2020 - 10.1096/fj.202000823R
FASEB Journal, Vol. 34 Núm. 9 (january 2020) , p. 12922-12931
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19 p, 397.7 KB |
Limit Cycles of Polynomially Integrable Piecewise Differential Systems
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García, Belén (Universidad de Oviedo. Departamento de Matemáticas) ;
Llibre, Jaume (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Pérez del Río, Jesús S. (Universidad de Oviedo. Departamento de Matemáticas) ;
Pérez-González, Set (Universidad de Oviedo. Departamento de Matemáticas)
In this paper, we study how many algebraic limit cycles have the discontinuous piecewise linear differential systems separated by a straight line, with polynomial first integrals on both sides. We assume that at least one of the systems is Hamiltonian. [...]
2023 - 10.3390/axioms12040342
Axioms, Vol. 12, Issue 4 (March 2023) , art. 342
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19 p, 6.0 MB |
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in down syndrome
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D'Acunzo, Pasquale (New York University. School of Medicine. Department of Psychiatry) ;
Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ;
Kim, Yohan (New York University. School of Medicine. Department of Psychiatry) ;
Hargash, Tal (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Miller, Chelsea (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Alldred, Melissa J. (Department of Psychiatry. New York University. School of Medicine) ;
Erdjument-Bromage, Hediye (New York University. School of Medicine. Kimmel Center for Biology and Medicine. The Skirball Institute) ;
Penikalapati, Sai Charan (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Pawlik, Monika (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Saito, Mitsuo (Division of Neurochemistry. Nathan S. Kline Institute for Psychiatric Research) ;
Saito, Mariko (New York University School of Medicine. Department of Psychiatry) ;
Ginsberg, Stephen D. (New York University. School of Medicine. Department of Neuroscience and Physiology) ;
Neubert, Thomas A. (Kimmel Center for Biology and Medicine. The Skirball Institute. New York University. School of Medicine) ;
Goulbourne, Chris N. (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Levy, Efrat (Department of Biochemistry and Molecular Pharmacology. New York University. School of Medicine)
Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer's disease (AD). Using a high-resolution density gradient separation of extracellular vesicles (EVs) isolated from murine and human DS and diploid control brains, we identify and characterize a previously unknown population of double-membraned EVs containing multiple mitochondrial proteins distinct from previously described EV subtypes, including microvesicles and exosomes. [...]
2021 - 10.1126/sciadv.abe5085
Science advances, Vol. 7 Núm. 7 (december 2021) , p. eabe5085
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21 p, 4.0 MB |
MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Malinverni, Roberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Carrillo-Reixach, Juan (Institut Germans Trias i Pujol) ;
Meers, Oliver (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Jaraquemada, Arce (Institut Germans Trias i Pujol) ;
Le Pannérer, Marguerite Marie (Universitat Pompeu Fabra) ;
Valero, Vanesa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pérez, Ainoha (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Del Río-Álvarez, Álvaro (Institut Germans Trias i Pujol) ;
Royo, Laura (Institut Germans Trias i Pujol) ;
Pérez-González, Beatriz (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Raurell Vila, Helena (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Acemel, Rafael D. (Universidad Pablo de Olavide) ;
Santos-Pereira, José M. (Universidad Pablo de Olavide) ;
Garrido-Pontnou, Marta (Hospital Universitari Vall d'Hebron) ;
Gómez-Skarmeta, José Luís (Centro Andaluz de Biología del Desarrollo (CABD). CSIC-Universidad Pablo de Olavide) ;
Pasquali, Lorenzo (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Manyé, Josep (Institut Germans Trias i Pujol) ;
Armengol, Carolina (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
MacroH2A histone variants have a function in gene regulation that is poorly understood at the molecular level. We report that macroH2A1. 2 and macroH2A2 modulate the transcriptional ground state of cancer cells and how they respond to inflammatory cytokines. [...]
2022 - 10.1016/j.celrep.2022.110988
Cell reports, Vol. 39 Núm. 12 (6 2022) , p. 110988
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5 p, 1016.9 KB |
Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington's disease
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Sampedro, Frederic (Institut d'Investigació Biomèdica Sant Pau) ;
Martinez-Horta, Saul (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez-Pérez, Jesús (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ;
Horta, Andrea (Institut d'Investigació Biomèdica Sant Pau) ;
Campolongo, Antonia (Institut d'Investigació Biomèdica Sant Pau) ;
Aracil-Bolaños, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Gómez-Ansón, Beatriz (Institut d'Investigació Biomèdica Sant Pau) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Female Huntington's disease (HD) patients have consistently shown a faster clinical worsening than male, but the underlying mechanisms responsible for this observation remain unknown. Here, we describe how sex modifies the impact of neurodegeneration on brain atrophy and clinical severity in HD. [...]
2021 - 10.1002/acn3.51460
Annals of Clinical and Translational Neurology, Vol. 8 Núm. 12 (december 2021) , p. 2309-2313
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5 p, 396.1 KB |
Increased plasma neurofilament light chain levels in patients with type-1 diabetes with impaired awareness of hypoglycemia
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Sampedro, Frederic (Institut d'Investigació Biomèdica Sant Pau) ;
Stantonyonge, Nicole (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Horta, Saül (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Muñoz, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ;
Marín-Lahoz, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Gómez-Ansón, Beatriz (Institut d'Investigació Biomèdica Sant Pau) ;
Chico Ballesteros, Ana (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Impaired awareness of hypoglycemia (IAH) is a common complication in patients with type-1 diabetes (T1D). IAH is a major risk factor for severe hypoglycemic events, leading to adverse clinical consequences and cerebral damage. [...]
2020 - 10.1136/bmjdrc-2020-001516
BMJ open diabetes research and care, Vol. 8 (july 2020)
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