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1.
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11 p, 3.9 MB |
Endothelium-Released Microvesicles Transport miR-126 That Induces Proangiogenic Reprogramming in Monocytes
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Arderiu, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Peña, Esther (Instituto de salud Carlos III) ;
Civit-Urgell, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
We have recently shown that in ischemic tissue, the hypoxic endothelial cells (EC) release extracellular microvesicles (EMVs) that are rich in tissue factor (TF). These TF-EMVs induce monocyte (Mo) homing to the ischemic zone, their differentiation into EC-like cells, and the formation of new blood vessels increasing tissue perfusion. [...]
2022 -  10.3389/fimmu.2022.836662
Frontiers in immunology, Vol. 13 (18 2022) , p. 836662
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2.
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12 p, 3.9 MB |
Characterization of Patient-Derived GNAQ Mutated Endothelial Cells from Capillary Malformations
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Langbroek, Ginger Beau (University of Amsterdam) ;
Stor, Merem L.E. (University of Amsterdam) ;
Janssen, Vera (University of Amsterdam) ;
de Haan, Annett (University of Amsterdam) ;
Horbach, Sophie E.R. (University of Amsterdam) ;
Graupera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
van Noesel, Carel J.M. (University of Amsterdam) ;
van der Horst, Chantal M.A.M. (University of Amsterdam) ;
Wolkerstorfer, Albert (University of Amsterdam) ;
Huveneers, Sthephan (University of Amsterdam)
Capillary malformations (CM) (port-wine stains) are congenital skin lesions that are characterized by dilated capillaries and postcapillary venules. CMs are caused by altered functioning of the vascular endothelium. [...]
2023 - 10.1016/j.jid.2023.10.033
The Journal of investigative dermatology, 2023
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3.
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6 p, 810.3 KB |
Translational medicine in hereditary hemorrhagic telangiectasia
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Riera Mestre, Antoni (Institut d'Investigació Biomèdica de Bellvitge) ;
Cerdà, Pau (Institut d'Investigació Biomèdica de Bellvitge) ;
Iriarte, Adriana (Institut d'Investigació Biomèdica de Bellvitge) ;
Graupera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Viñals, Francesc (Institut d'Investigació Biomèdica de Bellvitge)
Scientific community have gained lots of new insights in the genetic and biochemical background of different conditions, rare diseases included, settling the basis for preclinical models that are helping to identify new biomarkers and therapeutic targets. [...]
2022 - 10.1016/j.ejim.2021.09.003
European Journal of Internal Medicine, Vol. 95 (january 2022) , p. 32-37
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4.
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8 p, 6.1 MB |
Intravitreal administration of recombinant human opticin protects against hyperoxia-induced pre-retinal neovascularization
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Klaska, I.P. (Guy's Hospital, Great Maze Pond, London, UK) ;
White, Anne (University of Manchester, UK) ;
Villacampa, Pilar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Hoke, Justin (University College London, UK) ;
Abelleira-Hervas, Laura (University College London, UK) ;
Maswood, Ryea N. (University College London, UK) ;
Ali, Robin R. (Guy's Hospital, Great Maze Pond, London, UK) ;
Bunce, Catey (King's College London, Addison House, London, UK) ;
Unwin, Richard D. (University of Manchester, UK) ;
Cooper, Garth J.S. (University of Manchester, UK) ;
Bishop, Paul N. (Manchester University NHS Foundation Trust, UK) ;
Bainbridge, James W. (University College London, UK)
Opticin is an extracellular glycoprotein present in the vitreous. Its antiangiogenic properties offer the potential for therapeutic intervention in conditions such as proliferative diabetic retinopathy and retinopathy of prematurity. [...]
2022 - 10.1016/j.exer.2021.108908
Experimental Eye Research, Vol. 215 (february 2022)
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5.
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20 p, 2.0 MB |
Microvesicles in Atherosclerosis and Angiogenesis : From Bench to Bedside and Reverse
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Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Suades, Rosa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Arderiu, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Peña, Esther (Institut d'Investigació Biomèdica Sant Pau) ;
Chiva-Blanch, Gemma (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Atherosclerosis (AT) is a progressive chronic disease involving lipid accumulation, fibrosis, and inflammation in medium and large-sized arteries, and it is the main cause of cardiovascular disease (CVD). [...]
2017 - 10.3389/fcvm.2017.00077
Frontiers in Cardiovascular Medicine, Vol. 4 (18 2017) , p. 77
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7 p, 866.4 KB |
C-reactive protein in atherothrombosis and angiogenesis
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Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Peña, Esther (Institut d'Investigació Biomèdica Sant Pau) ;
Arderiu, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Slevin, M. (Manchester Metropolitan University) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Chiva-Blanch, Gemma (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
C-reactive protein (CRP) is a short pentraxin mainly found as a pentamer in the circulation, or as non-soluble monomers CRP (mCRP) in tissues, exerting different functions. This review is focused on discussing the role of CRP in cardiovascular disease, including recent advances on the implication of CRP and its forms specifically on the pathogenesis of atherothrombosis and angiogenesis. [...]
2018 - 10.3389/fimmu.2018.00430
Frontiers in immunology, Vol. 9 Núm. MAR (february 2018) , p. 430
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7.
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34 p, 2.3 MB |
Pot1 and damage response malfunction trigger acquisition of somatic activating mutations in the vegf pathway in cardiac angiosarcomas
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Calvete, Oriol (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
García-Pavía, Pablo (Universidad Francisco de Vitoria) ;
Domınguez, Fernando (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Mosteiro, Lluc (Centro Nacional de Investigaciones Oncológicas) ;
Perez Cabornero, Lucía (Parque Tecnologico de Valencia) ;
Cantalapiedra, Diego (Parque Tecnologico de Valencia) ;
Zorio, Esther (Hospital Universitari i Politècnic La Fe (València)) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Crespo-Leiro, Maria Generosa (Instituto de Investigación Biomédica de A Coruña (INIBIC)) ;
Teule, Alex (Hospital Universitari de Bellvitge) ;
Lazaro Garcia, Conxi (Hospital Universitari de Bellvitge) ;
Morente, Manuel M. (Centro Nacional de Investigaciones Oncológicas) ;
Urioste, Miguel (Centro Nacional de Investigaciones Oncológicas) ;
Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Mutations in the POT1 gene explain abnormally long telomeres and multiple tumors including cardiac angiosarcomas (CAS). However, the link between long telomeres and tumorigenesis is poorly understood. [...]
2019 - 10.1161/JAHA.119.012875
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 8 Núm. 18 (2019) , p. e012875
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8.
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9.
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5.3 MB |
Importance of Angiogenin and Endothelial Progenitor Cells After Rehabilitation Both in Ischemic Stroke Patients and in a Mouse Model of Cerebral Ischemia
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Gabriel Salazar, Marina (Hospital Universitari Vall d'Hebron) ;
Morancho, Anna (Hospital Universitari Vall d'Hebron) ;
Rodriguez, Susana (Hospital Universitari Vall d'Hebron) ;
Buxo Masip, Xavier (Hospital Universitari Vall d'Hebron) ;
García-Rodríguez, Nicolás (Hospital Universitari Vall d'Hebron) ;
Colell, Guillem (Hospital Universitari Vall d'Hebron) ;
Fernandez, Albert (Hospital Universitari Vall d'Hebron) ;
Giralt, Dolors (Hospital Universitari Vall d'Hebron) ;
Bustamante, Alejandro (Hospital Universitari Vall d'Hebron) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Background: Rehabilitation therapy is the only available treatment for stroke survivors presenting neurological deficits; however, the underlying molecules and mechanisms associated with functional/motor improvement during rehabilitation are poorly understood. [...]
2018 - 10.3389/fneur.2018.00508
Frontiers in neurology, Vol. 9 (june 2018)
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10.
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14 p, 1.0 MB |
Semen Modulates Inflammation and Angiogenesis in the Reproductive Tract of Female Rabbits
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Gardela Santacruz, Jaume (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Jauregi-Miguel, Amaia (Linköping University. Division of Molecular Medicine and Virology) ;
Martinez, Cristina A.. (Linköping University. Department of Biomedical and Clinical Sciences) ;
Rodriguez-Martinez, Heriberto (Linköping University. Department of Biomedical and Clinical Sciences) ;
López Béjar, Manel (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Álvarez-Rodríguez, Manuel (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
In mammals, the expression of regulatory genes is modified by the interaction between semen and the female reproductive tract. This study intends to unveil how mating or insemination with sperm-free seminal plasma, as well as the presence of preimplantation embryos, affects inflammation and angiogenesis in different segments of the reproductive tract of female rabbits. [...]
2020 - 10.3390/ani10122207
Animals, Vol. 10 (november 2020)
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