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1.
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22 p, 2.9 MB |
Advancing CART therapy for acute myeloid leukemia : recent breakthroughs and strategies for future development
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Pérez-Amill, Lorena (Department of Immunology. Centre de Diagnòstic Biomèdic (CDB). Hospital Clínic de Barcelona) ;
Bataller, Alex (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Delgado, Julio (Universitat de Barcelona) ;
Esteve, Jordi (Universitat de Barcelona) ;
Juan, Manel (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Klein-González, Nelia (Hospital Clínic i Provincial de Barcelona)
Chimeric antigen receptor (CAR) T therapies are being developed for acute myeloid leukemia (AML) on the basis of the results obtained for other haematological malignancies and the need of new treatments for relapsed and refractory AML. [...]
2023 -  10.3389/fimmu.2023.1260470
Frontiers in immunology, Vol. 14 (2023) , p. 1260470
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2.
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20 p, 1.1 MB |
RHOA Therapeutic Targeting in Hematological Cancers
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Santos, Juliana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sánchez Vinces, Salvador (Sao Francisco University Medical School, São Paulo, Brazil) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Primarily identified as an important regulator of cytoskeletal dynamics, the small GTPase Ras homolog gene family member A (RHOA) has been implicated in the transduction of signals regulating a broad range of cellular functions such as cell survival, migration, adhesion and proliferation. [...]
2023 - 10.3390/cells12030433
Cells, Vol. 12 Núm. 3 (february 2023) , p. 433
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3.
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50 p, 28.5 MB |
Pan-cancer proteogenomics connects oncogenic drivers to functional states
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Li, Yize (Washington University in St. Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tokheim, Collin (Harvard T.H. Chan School of Public Health) ;
Bailey, Matthew H. (Brigham Young University) ;
Yaron, Tomer (Weill Cornell Medicine) ;
Stathias, Vasileios (University of Miami Miller School of Medicine) ;
Geffen, Yifat (Massachusetts General Hospital) ;
Imbach, Kathleen (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cao, Song (McDonnell Genome Institute) ;
Anand, Shankara (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Akiyama, Yo (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Liu, Wenke (NYU Grossman School of Medicine) ;
Wyczalkowski, Matthew A. (McDonnell Genome Institute) ;
Song, Yizhe (McDonnell Genome Institute) ;
Storrs, Erik P. (McDonnell Genome Institute) ;
Wendl, Michael C. (Washington University in St. Louis) ;
Zhang, Wubing (Dana-Farber Cancer Institute (Boston, Estats Units)) ;
Sibai, Mustafa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ruiz-Serra, Victoria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Liang, Wen-Wei (McDonnell Genome Institute) ;
Terekhanova, Nadezhda V. (McDonnell Genome Institute) ;
Martins Rodrigues, Fernanda (McDonnell Genome Institute) ;
Clauser, Karl R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Heiman, David I. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Zhang, Qing (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Aguet, Francois (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Calinawan, Anna Pamela (Icahn School of Medicine at Mount Sinai) ;
Dhanasekaran, Saravana Mohan (University of Michigan) ;
Birger, Chet (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Satpathy, Shankha (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Zhou, Daniel Cui (McDonnell Genome Institute) ;
Wang, Liang-Bo (McDonnell Genome Institute) ;
Baral, Jessika (McDonnell Genome Institute) ;
Johnson, Jared L. (Weill Cornell Medicine) ;
Huntsman, Emily M. (Weill Cornell Medicine) ;
Pugliese, Pietro (University of Sannio (Benevento, Itàlia)) ;
Colaprico, Antonio (University of Miami Miller School of Medicine) ;
Iavarone, Antonio (University of Miami Miller School of Medicine) ;
Chheda, Milan G. (Washington University in St. Louis) ;
Ricketts, Christopher J. (National Institutes of Health) ;
Fenyö, David (NYU Grossman School of Medicine) ;
Payne, Samuel H. (Brigham Young University) ;
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research) ;
Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ;
Gillette, Michael A. (Harvard Medical School) ;
Kumar-Sinha, Chandan (University of Michigan) ;
Lazar, Alexander (The University of Texas MD Anderson Cancer Center) ;
Cantley, Lewis (Weill Cornell Medicine) ;
Getz, Gad A. (Harvard Medical School) ;
Ding, Li (Siteman Cancer Center) ;
An, Eunkyung ;
Anurag, Meenakshi ;
Bavarva, Jasmin ;
Birrer, Michael J. ;
Ceccarelli, Michele ;
Chan, Daniel W. ;
Chinnaiyan, Arul M. ;
Cho, Hanbyul ;
Chowdhury, Shrabanti ;
Cieslik, Marcin P. ;
da Veiga Leprevost, Felipe ;
Day, Corbin ;
Domagalski, Marcin J. ;
Dou, Yongchao ;
Druker, Brian J. ;
Edwards, Nathan ;
Ellis, Matthew J. ;
Selvan, Myvizhi Esai ;
Foltz, Steven M. ;
Francis, Alicia ;
Gonzalez Robles, Tania J. ;
Gosline, Sara J. C. ;
Gümüş, Zeynep H. ;
Hiltke, Tara ;
Hong, Runyu ;
Hostetter, Galen ;
Hu, Yingwei ;
Huang, Chen ;
Huntsman, Emily ;
Jaehnig, Eric J. ;
Jewel, Scott D. ;
Ji, Jiayi ;
Jiang, Wen ;
Katsnelson, Lizabeth ;
Ketchum, Karen A. ;
Kolodziejczak, Iga ;
Lei, Jonathan T. ;
Liao, Yuxing ;
Lindgren, Caleb M. ;
Liu, Tao ;
Ma, Weiping ;
McKerrow, Wilson ;
Nesvizhskii, Alexey I. ;
Newton, Chelsea ;
Oldroyd, Robert ;
Omenn, Gilbert S. ;
Paulovich, Amanda G. ;
Petralia, Francesca ;
Reva, Boris ;
Rodland, Karin D. ;
Ruggles, Kelly V. ;
Rykunov, Dmitry ;
Savage, Sara R. ;
Schadt, Eric E. ;
Schnaubelt, Michael ;
Schraink, Tobias ;
Shi, Zhiao ;
Smith, Richard D. ;
Song, Xiaoyu ;
Tan, Jimin ;
Thangudu, Ratna R. ;
Tignor, Nicole ;
Wang, Joshua M. ;
Wang, Pei ;
Wang, Ying Cindy ;
Wen, Bo ;
Wiznerowicz, Maciej ;
Yi, Xinpei ;
Zhang, Bing ;
Zhang, Hui ;
Zhang, Xu ;
Zhang, Zhen ;
Universitat Autònoma de Barcelona
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan-cancer analysis uncovers insights into the impacts of cancer drivers by identifying their significant cis-effects and distal trans-effects quantified at the RNA, protein, and phosphoprotein levels. [...]
2023 - 10.1016/j.cell.2023.07.014
Cell, Vol. 186 Núm. 18 (31 2023) , p. 3921-3944.e25
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4.
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9 p, 1.9 MB |
Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation
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Guglieri-Lopez, Beatriz (Hospital Universitari Doctor Peset (València)) ;
Perez-Pitarch, Alejandro (Hospital Clínico Universitario de València) ;
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Gimenez, Estela (Hospital Clínico Universitario de València) ;
Barba, Pere (Hospital Universitari Vall d'Hebron) ;
Rabella, Núria (Institut d'Investigació Biomèdica Sant Pau) ;
Hernandez-Boluda, Juan Carlos (Hospital Clínico Universitario de València) ;
Fox, Maria Laura (Hospital Universitari Vall d'Hebron) ;
Valcárcel, David (Hospital Universitari Vall d'Hebron) ;
Esquirol, Albert (Institut d'Investigació Biomèdica Sant Pau) ;
Ferriols-Lisart, Rafael (Hospital Clínico Universitario de València) ;
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Solano, Carlos (Universitat de València) ;
Navarro, David (Universitat de València) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Piñana, José Luis (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
The current study evaluates the clinical effect of sirolimus exposure on the occurrence of cytomegalovirus (CMV)DNAemia necessitating preemptive antiviral therapy. A total of 167 consecutive recipients of reduced-intensity conditioning (RIC)allogeneic hematopoietic stem cell transplantation (allo-HSCT)who received sirolimus- and tacrolimus-based graft-versus-host disease (GVHD)prophylaxis and whose CMV serostatus was positive for donors and/or recipients were included in this multicenter retrospective study. [...]
2019 - 10.1016/j.bbmt.2019.01.012
Biology of blood and marrow transplantation, Vol. 25 Núm. 5 (may 2019) , p. 1022-1030
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5.
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9 p, 267.6 KB |
VITAL phase 2 study : Upfront 5-fluorouracil, mitomycin-C, panitumumab and radiotherapy treatment in nonmetastatic squamous cell carcinomas of the anal canal (GEMCAD 09-02)
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Feliu, Jaime (Hospital Universitario La Paz (Madrid)) ;
Garcia-Carbonero, Rocio (Hospital Universitario 12 de Octubre (Madrid)) ;
Capdevila, J (Vall d'Hebron Institut d'Oncologia) ;
Guasch, Inmaculada (Hospital Althaia Assistencial de Manresa) ;
Alonso-Orduña, Vícente (Hospital Universitario Miguel Servet (Saragossa)) ;
López-López, Carlos A. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
García-Alfonso, Pilar (Hospital General Universitario Gregorio Marañón) ;
Castañón, Carmen (Hospital Virgen Blanca) ;
Sevilla, Isabel Ñíguez (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Cerezo, Laura (Hospital Universitario de la Princesa (Madrid)) ;
Conill, Carlos (Universitat de Barcelona) ;
Quintana Ángel, Begoña (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Sánchez, María E. (Hospital Universitario La Paz (Madrid)) ;
Ghanem, Ismael (Hospital Universitario La Paz (Madrid)) ;
Martín-Richard, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Lopez-Gomez, Miriam (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes)) ;
León, Ana Isabel (Hospital Universitario Fundacion Jimenez Diaz) ;
Caro, Monica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fernandez, Teresa López (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Maurel, Joan (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona
VITAL, a phase II single-arm study, aimed to evaluate efficacy and safety of panitumumab addition to 5-fluorouracil (5-FU), mitomycin-C (MMC) and radiotherapy (RT) in patients with localized squamous cell carcinoma of the anal canal (SCCAC). [...]
2020 - 10.1002/cam4.2722
Cancer Medicine, Vol. 9 Núm. 3 (january 2020) , p. 1008-1016
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7.
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7 p, 586.0 KB |
Progress toward equitably managed protected areas in Aichi target 11 : a global survey
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Zafra-Calvo, Noelia (University of Copenhagen.) ;
Garmendía, Eneko (Universidad del País Vasco) ;
Pascual, Unai 1973- (Basque Centre for Climate Change (Bilbao)) ;
Palomo, Ignacio (Basque Centre for Climate Change (Bilbao)) ;
Gross-Camp, Nicole (University of East Anglia) ;
Brockington, Dan (The University of Sheffield) ;
Cortes Vazquez, Jose Antonio (Universidade da Coruña) ;
Coolsaet, Brendan (University of East Anglia) ;
Burgess, Neil David (University of Copenhagen)
The Convention on Biological Diversity Aichi Target 11 requires its 193 signatory parties to incorporate social equity into protected area (PA) management by 2020. However, there is limited evidence of progress toward this commitment. [...]
2019 - 10.1093/biosci/biy143
BioScience, Vol. 69 Núm. 3 (2019) , p. 191-197
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8.
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24 p, 2.9 MB |
Repeatedly Northwards and Upwards : Southern African Grasslands Fuel the Colonization of the African Sky Islands in Helichrysum (Compositae)
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Blanco-Gavaldà, Carme (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Galbany-Casals, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Susanna, Alfonso (Institut Botànic de Barcelona) ;
Andrés-Sánchez, Santiago (University of Salamanca. Department of Botany and Plant Physiology and Plant DNA Biobank) ;
Bayer, Randall J. (University of Memphis. Department of Biological Sciences, Center for Biodiversity) ;
Brochmann, Christian (University of Oslo. Natural History Museum) ;
Cron, Glynis V. (University of the Witwatersrand. School of Animal, Plant and Environmental Sciences) ;
Bergh, Nicola G. (South African National Biodiversity Institute) ;
Garcia-Jacas, Núria (Institut Botànic de Barcelona) ;
Gizaw, Abel (Addis Ababa University. Department of Plant Biology and Biodiversity Management) ;
Kandziora, Martha (Charles University in Prague. Department of Botany) ;
Kolář, Filip (Academy of Sciences of the Czech Republic) ;
López-Alvarado, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Leliaert, Frederik (Meise Botanic Garden) ;
Letsara, Rokiman (Herbarium of the Parc Botanique et Zoologique of Tsimbazaza) ;
Moreyra, Lucía D. (Institut Botànic de Barcelona) ;
Razafimandimbison, Sylvain G. (Swedish Museum of Natural History. Department of Botany) ;
Schmickl, Roswitha (Institute of Botany, Academy of Sciences of the Czech Republic) ;
Roquet, Cristina (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
The Afromontane and Afroalpine areas constitute some of the main biodiversity hotspots of Africa. They are particularly rich in plant endemics, but the biogeographic origins and evolutionary processes leading to this outstanding diversity are poorly understood. [...]
2023 - 10.3390/plants12112213
Plants, Vol. 12, Issue 11 (June 2023) , art. 2213
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9.
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23 p, 4.6 MB |
Development of New Targeted Nanotherapy Combined with Magneto-Fluorescent Nanoparticles against Colorectal Cancer
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Marcelo, Gonçalo A. (Universidade Nova de Lisboa. Departamento de Química) ;
Montpeyó Garcia-Moreno, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Galhano, Joana (Universidade Nova de Lisboa. Departamento de Química) ;
Martínez-Máñez, Ramón (Universitat Politècnica de València. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico) ;
Capelo-Martínez, José Luis (Universidade Nova de Lisboa. Departamento de Química) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lodeiro, Carlos (Universidade Nova de Lisboa. Departamento de Química) ;
Oliveira, Elisabete (Universidade Nova de Lisboa. Departamento de Química)
The need for non-invasive therapies capable of conserving drug efficiency and stability while having specific targetability against colorectal cancer (CRC), has made nanoparticles preferable vehicles and principal building blocks for the development of complex and multi-action anti-tumoral approaches. [...]
2023 - 10.3390/ijms24076612
International journal of molecular sciences, Vol. 24, Issue 7 (April 2023) , art. 6612
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10.
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11 p, 5.8 MB |
Chemicals of emerging concern in coastal aquifers : Assessment along the land-ocean interface
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Gutiérrez-Martín, Daniel (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Gil-Solsona, Rubén (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Saaltink, Maarten W. (Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental) ;
Rodellas, Valentí (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
López-Serna, Rebeca (Universidad de Valladolid. Instituto de Procesos Sustentables) ;
Folch, Albert (Universitat Politècnica de Catalunya. Departament d'Enginyeria Civil i Ambiental) ;
Carrera, Jesús (Institut de Diagnòstic Ambiental i Estudis de l'Aigua) ;
Gago-Ferrero, Pablo (Institut de Diagnòstic Ambiental i Estudis de l'Aigua)
Submarine Groundwater Discharge (SGD) is recognized as a relevant source of pollutants to the sea, but little is known about its relevance as a source of chemicals of emerging concern (CECs). Here, both the presence and distribution of a wide range of CECs have been evaluated in the most comprehensive manner to date, in a well-characterized Mediterranean coastal aquifer near Barcelona (Spain). [...]
2023 - 10.1016/j.jhazmat.2023.130876
Journal of hazardous materials, Vol. 448 (April 2023) , art. 130876
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