Institut de Biotecnologia i de Biomedicina (IBB)

L’ Institut de Biotecnologia i de Biomedicina (IBB) va ser creat el 1970 com a institut de recerca de la Universitat Autònoma de Barcelona (UAB). Tot i que l’institut es va dedicar originalment a promoure la investigació biològica fonamental, ens hem centrat en els camps de Biotecnologia i Biomedicina durant els darrers vint anys.

A l'IBB portem a terme investigacions científiques capdavanteres amb l'objectiu d'avançar en el coneixement i poder traduir les troballes científiques en eines tangibles, per revertir el nostre coneixement a la societat. Els nostres investigadors participen en convocatòries altament competitives, tant nacionals com internacionals, destinades a finançar investigacions bàsiques i translacionals.

Entre els més de 200 investigadors que actualment treballen a l’IBB, hi ha professors de la UAB, ICREA i altres investigadors sèniors, becaris postdoctorals i estudiants de doctorat o de màster. L’IBB acull 18 grups de recerca organitzats en 3 programes que abasten diferents àrees d’expertesa científica que inclouen bioinformàtica, biologia cel·lular i estructural, genòmica, immunologia, microbiologia i proteòmica.

El nostre caràcter multidisciplinari, una de les característiques més rellevants de l’IBB, permet un enfocament ampli dels problemes biològics, tant bàsics com aplicats. Els investigadors de l'IBB tenen experiència en diversos temes dins de la biomedicina i en el camp de la biotecnologia.

Estadístiques d'ús Els més consultats
Darreres entrades:
2020-07-06
04:48
15 p, 4.1 MB Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity / Carija, Anita (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pinheiro, Francisca (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pujols, Jordi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Brás, Inês C. (University Medicine Göttingen) ; Lázaro, Diana Fernandes (University Medicine Göttingen) ; Santambrogio, Carlo (University of Milano-Bicocca. Dipartimento di Biotecnologie e Bioscienze) ; Grandori, Rita (University of Milano-Bicocca. Dipartimento di Biotecnologie e Bioscienze) ; Outeiro, Tiago F. (Max Planck Institute for Experimental Medicine) ; Navarro Cantero, Susanna (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. The mechanisms underlying the structural transition of soluble and innocuous α-syn to aggregated neurotoxic forms remains largely unknown. [...]
2019 - 10.1016/j.redox.2019.101135
Redox Biology, Vol. 22 (April 2019) , art. 101135  
2020-06-22
12:28
112 p, 6.6 MB Annual report / Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Informe annual de l'Institut de Biotecnologia i Biomedicina "Vicent Villar Palasí".
Bellaterra Institut de Biotecnologia i Biomedicina 2013-
7 documents
2020-06-22
11:26
15 p, 1.4 MB E-cigarettes : effects in phagocytosis and cytokines response against Mycobacterium tuberculosis / Gómez Camacho, Andromeda Celeste (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rodríguez Fernández, Pablo (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ; Villar Hernández, Raquel (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ; Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Muriel Moreno, Beatriz (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ; Lacoma, Alicia (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ; Prat Aymerich, Cristina (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol) ; Domínguez, José (Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol)
Cigarette smoking and tuberculosis are a significant cause of death worldwide. Several epidemiological studies have demonstrated cigarette smoking is a risk factor for tuberculosis. Electronic cigarettes have recently appeared as a healthier alternative to conventional smoking, although their impact in tuberculosis is not well understood. [...]
2020 - 10.1371/journal.pone.0228919
PLoS ONE, Vol. 15 issue 2 (2020) , p. e0228919  
2020-06-22
11:26
41 p, 2.4 MB Autophagy modulators : mechanistic aspects and drug delivery systems / Tavakol, Shima (Iran University of Medical Sciences. Cellular and Molecular Research Center) ; Ashrafizadeh, Milad (University of Tabriz. Department of basic science) ; Deng, Shuo (National University of Singapore. Department of Physiology) ; Azarian, Maryam (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Abdoli, Asghar (Pasteur Institute of Iran. Department of Hepatitis and AIDS) ; Motavaf, Mahsa (Tarbiat Modares University. Department of Molecular Genetics) ; Poormoghadam, Delaram (Islamic Azad University. Department of Medical Nanotechnology) ; Khanbabaei, Hashem (Ahvaz Jundishapur University of Medical Sciences. Medical Physics Departmen) ; Ghasemipour Afshar, Elham (Kerman University of Medical Sciences. Neuroscience Research Center) ; Mandegary, Ali (Kerman University of Medical Sciences. Neuroscience Research Center) ; Pardakhty, Abbas (Kerman University of Medical Sciences. Neuroscience Research Center) ; Yap, Celestial T. (National University of Singapore. Department of Physiology) ; Mohammadinejad, Reza (Kerman University of Medical Sciences. Pharmaceutics Research Center) ; Prem Kumar, Alan (Cancer Science Institute of Singapore) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytostatic role in the progression and prevention of disease. [...]
2019 - 10.3390/biom9100530
Biomolecules, Vol. 9, issue 10 (Sep. 2019) , art. 530  
2020-06-22
11:26
509.8 KB Inducing α-synuclein compaction : a new strategy for inhibiting α-synuclein aggregation? / Pinheiro, Francisca (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
2019 - 10.4103/1673-5374.259608
Neural Regeneration Research, Vol. 14, issue 11 (Nov. 2019) , p. 1897-1898  
2020-06-22
11:26
18 p, 3.6 MB hnRNPDL phase separation is regulated by alternative splicing and disease-causing mutations accelerate its aggregation / Batlle Carreras, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yang, Peiguo (St. Jude Children's Research Hospital. Department of Cell and Molecular Biology) ; Coughlin, Maura (St. Jude Children's Research Hospital. Department of Cell and Molecular Biology) ; Messing, James (Howard Hughes Medical Institute) ; Pesarrodona Roches, Mireia (Institut de Recerca Biomèdica) ; Szulc, Elzbieta (Institut de Recerca Biomèdica) ; Salvatella, Xavier (Institut de Recerca Biomèdica) ; Kim, Hong Joo (St. Jude Children's Research Hospital. Department of Cell and Molecular Biology) ; Taylor, J. Paul (Howard Hughes Medical Institute) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prion-like proteins form multivalent assemblies and phase separate into membraneless organelles. Heterogeneous ribonucleoprotein D-like (hnRNPDL) is a RNA-processing prion-like protein with three alternative splicing (AS) isoforms, which lack none, one, or both of its two disordered domains. [...]
2020 - 10.1016/j.celrep.2019.12.080
Cell reports, Vol. 30, issue 4 (Jan. 2020) , p. 1117-1128  
2020-06-22
11:26
12 p, 5.4 MB The biofilm-associated surface protein Esp of Enterococcus faecalis forms amyloid-like fibers / Taglialegna, Agustina (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Agrobiotecnología) ; Matilla-Cuenca, Leticia (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Agrobiotecnología) ; Dorado-Morales, Pedro (Universidad Pública de Navarra. Departamento de Salud) ; Navarro Cantero, Susanna (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Garnett, James A. (Centre for Host Microbiome Interactions. Dental institute. King's College London) ; Lasa, Iñigo (Universidad Pública de Navarra. Departamento de Salud) ; Valle, Jaione (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Agrobiotecnología)
Functional amyloids are considered as common building block structures of the biofilm matrix in different bacteria. In previous work, we have shown that the staphylococcal surface protein Bap, a member of the Biofilm-Associated Proteins (BAP) family, is processed and the fragments containing the N-terminal region become aggregation-prone and self-assemble into amyloid-like structures. [...]
2020 - 10.1038/s41522-020-0125-2
npj Biofilms and Microbiomes, Vol. 6, issue 1 (2020) , art. 15  
2020-06-22
11:26
14 p, 3.3 MB Interaction of camel Lactoferrin derived peptides with DNA : a molecular dynamics study / Pirkhezranian, Zana (Ferdowsi University of Mashhad. Department of Animal Science) ; Tahmoorespur, Mojtaba. (Ferdowsi University of Mashhad. Department of Animal Science) ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Monhemi, Hassan (University of Neyshabur. Department of Chemistry) ; Sekhavati, Mohammad Hadi (Ferdowsi University of Mashhad. Department of Animal Science)
Background: lactoferrampin (LFampin), Lactoferricin (LFcin), and LFchimera are three well-known antimicrobial peptides derived from Lactoferrin and proposed as alternatives for antibiotics. Although the intracellular activity of these peptides has been previously demonstrated, their mode of action is not yet fully understood. [...]
2020 - 10.1186/s12864-020-6458-7
BMC genomics, Vol. 21 (2020) , art. 60  
2020-06-22
11:26
13 p, 1.3 MB Chromosomal differentiation in genetically isolated populations of the marsh-specialist crocidura suaveolens (Mammalia : Soricidae) / Garcia, Francisca (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ; Biedma, Luis (Universidad de Huelva. Departamento de Ciencias Integradas) ; Calzada, Javier (Universidad de Huelva. Departamento de Ciencias Integradas) ; Román, Jacinto (Estación Biológica de Doñana) ; Lozano, Alberto, 1966- (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cortés, Francisco (Universitat Autònoma de Barcelona. Servei de Cultius Cel·lulars, Producció d'Anticossos i Citometria) ; Godoy, José A. (Estación Biológica de Doñana) ; Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cellular, Fisiologia i Immunologia)
The genus Crocidura represents a remarkable model for the study of chromosome evolution. This is the case of the lesser white-toothed shrew (Crocidura suaveolens), a representative of the Palearctic group. [...]
2020 - 10.3390/genes11030270
Genes, Vol. 11, issue 3 (March 2020) , art. 270  
2020-06-22
11:26
16 p, 21.0 MB Transcriptional response to metal starvation in the emerging pathogen Mycoplasma genitalium is mediated by Fur-dependent and -independent regulatory pathways / Martínez Torró, Carlos (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Torres Puig, Sergi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Monge, Marta (Vall d'Hebron. Institut d'Oncologia) ; Sánchez Alba, Lucía (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González Martín, Miguel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcos Silva, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Perálvarez Marín, Alejandro (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Canals, Francesc (Vall d'Hebron. Institut d'Oncologia) ; Querol Murillo, Enrique (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Piñol Ribas, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Quijada Pich, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Transition metals participate in numerous enzymatic reactions and they are essential for survival in all living organisms. For this reason, bacterial pathogens have evolved dedicated machineries to effectively compete with their hosts and scavenge metals at the site of infection. [...]
2020 - 10.1080/22221751.2019.1700762
Emerging microbes & infections, Vol. 9, issue 1 (Jan. 2020) , p. 5-19