Adaptive evolution is substantially impeded by Hill-Robertson interference in Drosophila
Castellano Esteve, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Coronado-Zamora, Marta (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Campos, Jose L. (University of Edinburgh. Institute of Evolutionary Biology, School of Biological Sciences)
Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Eyre-Walker, Adam (University of Sussex. Centre for the Study of Evolution, School of Life Sciences)
Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia

Data:	2015
Resum:	Hill-Robertson interference (HRi) is expected to reduce the efficiency of natural selection when two or more linked selected sites do not segregate freely, but no attempt has been done so far to quantify the overall impact of HRi on the rate of adaptive evolution for any given genome. In this work, we estimate how much HRi impedes the rate of adaptive evolution in the coding genome of Drosophila melanogaster. We compiled a data set of 6,141 autosomal protein-coding genes from Drosophila, from which polymorphism levels in D. melanogaster and divergence out to D. yakuba were estimated. The rate of adaptive evolution was calculated using a derivative of the McDonald-Kreitman test that controls for slightly deleterious mutations. We find that the rate of adaptive amino acid substitution at a given position of the genome is positively correlated to both the rate of recombination and the mutation rate, and negatively correlated to the gene density of the region. These correlations are robust to controlling for each other, for synonymous codon bias and for gene functions related to immune response and testes. We show that HRi diminishes the rate of adaptive evolution by approximately 27%. Interestingly, genes with low mutation rates embedded in gene poor regions lose approximately 17% of their adaptive substitutions whereas genes with high mutation rates embedded in gene rich regions lose approximately 60%. We conclude that HRi hampers the rate of adaptive evolution in Drosophila and that the variation in recombination, mutation, and gene density along the genome affects the HRi effect.
Ajuts:	Ministerio de Economía y Competitividad AP2008/02405 Ministerio de Economía y Competitividad BUF2013/42649-P Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1346 Agència de Gestió d'Ajuts Universitaris i de Recerca 2015/FI-DGR
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Hill-Robertson ; Adaptation ; Recombination ; Mutation ; Drosophila ; Gene density
Publicat a:	Molecular biology and evolution, Vol. 33, Núm. 2 (October 2015) , p. 442-455, ISSN 1537-1719

DOI: 10.1093/molbev/msv236
PMID: 26494843

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